Results 101 to 110 of about 31,996 (262)

Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects [PDF]

, 2012
A broad spectrum of beneficial effects has been ascribed to creatine (Cr), phosphocreatine (PCr) and their cyclic analogues cyclo-(cCr) and phospho-cyclocreatine (PcCr).
Schlattner, Uwe, Meier, Beat, Epand, Raquel F., Meier, Beat H., Neumann, Dietbert, Wallimann, Theo, Neumann, Dietbert; id_orcid, Widmer, Hans, R., van Veen, Hendrik, Wallimann, Theo; id_orcid, Epand, Richard M., Meiler, Flurina, Uwe Schlattner, Dietbert Neumann, Epand, Richard, M., Tokarska-Schlattner, Malgorzata, Saks, Valdur, A, Theo Wallimann, Saks, Valdur, Epand, Raquel, F., Zandomeneghi, Giorgia, Raquel F Epand, Malgorzata Tokarska-Schlattner, Giorgia Zandomeneghi, Valdur Saks, Flurina Meiler, Hans R Widmer, Beat H Meier, Widmer, Hans R., Richard M Epand   +29 more
core   +3 more sources

FGF23 promotes atrial fibrillation susceptibility through ETV1‐dependent sodium channel regulation and calcium handling abnormalities

Experimental Physiology, EarlyView.
Abstract Fibroblast growth factor 23 (FGF23) is closely associated with atrial fibrillation (AF), yet whether it modulates sodium and calcium currents in atrial myocytes remains unclear. ETV1, a key transcription factor regulating atrial electrical conduction, might also be involved in FGF23‐mediated AF.
Qiaoting Yu, Linwen Zeng, Zhijie Chen, Zhuhui Lin, Congying Wang, Lan Wang, Huixian Fu, Jiancheng Zhang   +7 more
wiley   +1 more source

Comparative assessment of hepatoprotective effects of various liposome formulations in experimental venous congestion-induced chronic liver insufficiency

Бюллетень сибирской медицины, 2012
The aim of the study was to evaluate the efficacy of lecithin/cholesterol liposomes in the therapy of experimental venous congestion-induced chronic liver insufficiency. The effects of the empty liposomes, ATP and phosphocreatine-containing liposomes and
R. A. Mukhamadiyarov, N. L. Vorontsova, V. V. Borisov, Yu. A. Kudryavtseva, I. Yu. Juravleva   +4 more
doaj   +1 more source

Distinct electrophysiology and dopaminergic modulation of medium spiny neurons across divisions of the tail striatum and the dorsolateral striatum

Experimental Physiology, EarlyView.
Abstract The striatum is a brain region within the basal ganglia that plays a crucial role in generating behaviour and mediating perception. The tail striatum (TS) is a poorly understood striatal domain with predominantly sensory functions. Recent evidence supports that abnormal TS dopamine transmission in dopaminergic disease contributes to sensory ...
Bronwyn Riley, Luke E. Hallum, Srdjan M. Vlajkovic, Johanna M. Montgomery, Peter S. Freestone   +4 more
wiley   +1 more source

Typical experimental data (phosphocreatine concentration, normalised to resting values, in recovery from dynamic exercise) and a monoexponential function (solid line), fitted as described in Methods.

, 2013
Typical experimental data (phosphocreatine concentration, normalised to resting values, in recovery from dynamic exercise) and a monoexponential function (solid line), fitted as described in Methods.
Kieran Clarke (88473), Andrew Johnson (29446), Cameron J. Holloway (319798), Graham J. Kemp (295442), Renee M. Dwyer (319796), Lindsay M. Edwards (319793), Alan M. Nevill (319799), Damian J. Tyler (189576)   +7 more
core   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Artificial mitochondria ameliorates osteoarthritis through restoring cellular energy metabolism homeostasis

Bioactive Materials
Mitochondrial dysfunction under pathological or aging conditions disrupts adenosine triphosphate (ATP) synthesis, exacerbating disease progression by skewing energy metabolism toward catabolism.
Wenqiang Yan, Yu Chen, Haoda Wu, Zeyuan Gao, Xiaoqing Hu, Yingfang Ao, Chun Mao, Mimi Wan   +7 more
doaj   +1 more source

Influence of phosphocreatine on mitochondrial activity in patients with angina pectoris

, 2016
The research of individual sensitivity of leukocytes’ mitochondria of 56 patients with a stable angina pectoris to introduction of phosphocreatine in tests in vitro have been made.
Zhernakova, N. I., Nikolaev, S. B., Stepchenko, A. A., Romaschenko, O. V., Lazareva, G. A.   +4 more
core