Results 121 to 130 of about 31,996 (262)

Physical training attenuates phosphocreatine and long-chain acyl-CoA alterations in diabetic rat heart

, 1993
This study was designed to assess the effect of physical training on high-energy phosphate levels in the heart of diabetic rats. Diabetes was induced with streptozocin (50 mg/kg), and exercise training was carried out on a treadmill with a progressive ...
G. Tancrede, N. Mokhtar, A. Nadeau, S. Rousseau-Migneron   +3 more
core   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Diving into the unknown: Evidence of enhanced skeletal muscle lactate efflux potential and blood–muscle exchange in competitive breath‐hold divers

The Journal of Physiology, EarlyView.
Abstract figure legend Competitive breath‐hold divers exhibit skeletal muscle characteristics indicative of enhanced blood‐muscle exchange capacity and increased lactate efflux potential. Top left: Participant characteristics, matched for age, height, body mass, and maximal oxygen uptake (V̇O2max${\dot{\mathrm{V}}}\rm{O}_{\rm{2max}}$).
Antonis Elia, Matthew Lees, John O'Hara, Nathan Hodson, Jordan Acheson, Oliver Wilson, Paul Parker, Matthew Barlow   +7 more
wiley   +1 more source

Efficacy and safety of creatine phosphate sodium in the treatment of viral myocarditis: A systematic review and meta-analysis.

PLoS ONE
PurposeTo systematically evaluate the efficacy and safety of creatine phosphate sodium in the treatment of viral myocarditis, and to provide guidance for its clinical treatment.MethodsWe conducted a search of The Cochrane Library, PubMed, EMbase, and Web
Li Wang, Su-Fang Chen, Xi-Wei Huang, Zhi-Yang Wu, Qing-Mei Zhang   +4 more
doaj   +1 more source

The role of group III/IV afferent feedback in the ventilatory, pressor and metabolic responses to exercise in normoxia and hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Participants completed cycling exercise with (placebo) and without (25 µg intrathecal fentanyl) intact group III/IV muscle afferent feedback in three settings: normoxia, acute hypoxia and chronic hypoxia after 7–9 days of acclimatisation (∼3800 m). Blocking afferent feedback suppressed exercise hyperpnoea across all environments,
Elliott J. Jenkins, Phuong L. Ha, Connor A. Howe, Jay M. J. R. Carr, Justin A. Monteleone, Andrew J. M. Douglas, Abigail Nicholson, Andrew Steele, Brydie Lemkes, Jodie L. Koep, L. Madden Brewster, Jennifer Duffy, Mathew I. B. Debenham, Tena Monaghan, Declan Isaak, Jacob McCormick, Brian H. Dalton, Chris J. McNeil, Jared Baylis, David MacLeod, Mike Stembridge, Markus Amann, Philip N. Ainslie, Travis D. Gibbons   +23 more
wiley   +1 more source

Spatial mapping of the concentrations of phosphocreatine in the human myocardium in vivo

, 2000
The energy requirements for cardiac function are supplied almost entirely through oxidative phosphorylation in the mitochondria. Therefore, the consequences of ischemic heart disease are manifested in metabolic changes which are immediately detectable ...
Greenman, Robert Loyal
core  

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source

31P saturation transfer and phosphocreatine imaging in the monkey brain

, 1991
31P magnetic resonance imaging with chemical-shift discrimination by selective excitation has been employed to determine the phosphocreatine (PCr) distribution in the brains of three juvenile macaque monkeys.
Allman, J., Mora, B., Barker, P. B., Narasimhan, P. T., Ross, B. D.   +4 more
core   +1 more source

Complex formation equilibria of phosphocreatine with sodium, potassium and magnesium ions

, 2002
The formation of complexes between phosphocreatine, H2O3PNHC(=NH)N(CH3)CH2CO2H, and the ions Na+, K+ and Mg2+ have been investigated under physiological conditions (aqueous solution, T=37degreesC and I=0.25 mol dm(-3)) by means of P-31 NMR spectroscopy ...
F. Cecconi, S. Midollini, P. Gans, A. Sabatini, S. Iotti, FRASSINETI, Chiara, A. Vacca   +6 more
core   +1 more source

Short Echo‐Time Spiral MRSI Versus Single‐Voxel Spectroscopy in the Human Brain at 3 Tesla With Semi‐LASER Localization

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1524-1533, October 2026.
ABSTRACT Purpose Magnetic resonance spectroscopy techniques are widely used to non‐invasively study brain metabolism. Despite advances in magnetic resonance spectroscopic imaging (MRSI), there is a notable absence of research on comparing fast non‐Cartesian MRSI with single‐voxel spectroscopy (SVS), limiting our understanding of its performance and ...
Young Woo Park, Isaac M. Adanyeguh, Pierre‐Gilles Henry, Dinesh K. Deelchand   +3 more
wiley   +1 more source