Results 121 to 130 of about 44,180 (297)

A Review of Phosphocreatine 3 Kinase d Subtype (PI3Kδ) and Its Inhibitors in Malignancy

, 2021
Qiong Xiang, Shuai Dong, Xian-Hui Li
openalex   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Prognostic performance of magnetic resonance spectrometry in patients with diffuse axonal injury: A prospective cohort study

Interdisciplinary Neurosurgery
Background: Traumatic brain injury (TBI) is a global concern, and many people suffer from TBI annually. Determining the outcome of patients with brain injury has a valuable clinical impact and results in better management of patients.
Mohammad Ali Abouei Mehrizi, Ehsan Keykhosravi, Mohammad Reza Ehsaei, Mohaddeseh Sadat Alavi, Ali Shamsa, Mohammad Amin Habibi, Sajjad Ahmadpour   +6 more
doaj   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Optimal Pacing for Running 400 m and 800 m Track Races

, 2012
Physicists seeking to understand complex biological systems often find it rewarding to create simple "toy models" that reproduce system behavior. Here a toy model is used to understand a puzzling phenomenon from the sport of track and field.
Baumann W., Gajer B., Hanon C., Hirvonen J., Hultman E., James Reardon, Matrahazi Imre, Sage A., Sahlin K., Čoh M.   +9 more
core   +1 more source

Hypoadrenocorticism‐like syndrome in a cat with Tritrichomonas foetus infection: a case report

Journal of Small Animal Practice, EarlyView.
A reduced sodium: potassium ratio is an uncommon finding in cats, and is typically associated with conditions such as hypoadrenocorticism, severe renal and cardiovascular diseases, cavitary effusion and certain non‐parasitic gastrointestinal diseases.
M. Crisonà, F. Fracassi, A. M. Tardo, S. Okonji, F. Del Baldo   +4 more
wiley   +1 more source

Comparative assessment of hepatoprotective effects of various liposome formulations in experimental venous congestion-induced chronic liver insufficiency

Бюллетень сибирской медицины, 2012
The aim of the study was to evaluate the efficacy of lecithin/cholesterol liposomes in the therapy of experimental venous congestion-induced chronic liver insufficiency. The effects of the empty liposomes, ATP and phosphocreatine-containing liposomes and
R. A. Mukhamadiyarov, N. L. Vorontsova, V. V. Borisov, Yu. A. Kudryavtseva, I. Yu. Juravleva   +4 more
doaj   +1 more source

Photobiomodulation and platelet‐rich fibrin in the gastrocnemius muscle submitted to calcaneal tendinopathy in rats

Photochemistry and Photobiology, EarlyView.
The study evaluated different treatments for calcaneal tendinopathy in rats, focusing on the gastrocnemius muscle. Photobiomodulation (PBM), advanced platelet‐rich fibrin (A‐PRF), and their combination were tested. Treated animals showed improved muscle strength between 7 and 21 days, but without significant recovery of muscle fibers.
Pâmela Andressa Pauletto, Caroline Hammerschmitt Eduardo Schmitt, Fransael Franklyn Araújo da Silva, Maria Eduarda Luckner, Lucinéia de Fátima Chasko Ribeiro, Márcia Miranda Torrejais, Gladson Ricardo Flor Bertolini   +6 more
wiley   +1 more source

Improved Exercise Tolerance with Caffeine Is Associated with Modulation of both Peripheral and Central Neural Processes in Human Participants

Frontiers in Nutrition, 2018
BackgroundCaffeine has been shown to enhance exercise performance and capacity. The mechanisms remain unclear but are suggested to relate to adenosine receptor antagonism, resulting in increased central motor drive, reduced perception of effort, and ...
Joanna L. Bowtell, Magni Mohr, Magni Mohr, Magni Mohr, Jonathan Fulford, Sarah R. Jackman, Georgios Ermidis, Georgios Ermidis, Georgios Ermidis, Peter Krustrup, Peter Krustrup, Katya N. Mileva   +11 more
doaj   +1 more source

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles [PDF]

, 2020
J. Matthew Hinkley, Heather H. Cornnell, Robert A. Standley, Emily Y. Chen, Niven R. Narain, Bennett Greenwood, Valerie Bussberg, Vladimir Tolstikov, Michael A. Kiebish, Fanchao Yi, Rick B. Vega, Bret H. Goodpaster, Paul M. Coen   +12 more
openalex   +1 more source