Results 141 to 150 of about 26,828 (231)

Blood Flow Restriction Does Not Impair Single, All‐Out Sprint Cycling Performance

open access: yesEuropean Journal of Sport Science, Volume 26, Issue 6, June 2026.
ABSTRACT This study examined the effects of sprint duration and blood flow restriction due to cuff pressure applied only during exercise on sprint cycling performance and psychophysiological responses. On separate days, 12 physically active young adults (9 men and 3 women) performed six ‘all‐out’ cycling sprints (5, 10, 15, 20, 25 and 30 s) in a ...
Carlos Dellavechia de Carvalho   +7 more
wiley   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

open access: yesJournal of Magnetic Resonance Imaging, Volume 63, Issue 6, Page 1509-1545, June 2026.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca   +3 more
wiley   +1 more source

Differentiating Creatine and Phosphocreatine In Vivo Using 3 T 1H MR Spectroscopy. [PDF]

open access: yesMagn Reson Med
Hurd RE   +9 more
europepmc   +1 more source

Spectral Representation of Neurochemicals With Phase, Frequency Offset, and Lineshape Invariance: Application to JPRESS for In Vivo Concentration and T2 Mapping by Deep Learning

open access: yesMagnetic Resonance in Medicine, Volume 95, Issue 6, Page 3052-3064, June 2026.
ABSTRACT Purpose Using artificial intelligence neural networks to generate a representation that maps the input directly to neurochemical concentrations and metabolite‐level average transverse relaxation times (T2). Methods The proposed model used time‐domain JPRESS data as input and was trained to be invariant to phase shifts, frequency offsets, and ...
Yan Zhang, Jun Shen
wiley   +1 more source

Recent advances in phosphocreatine metabolism and its role in cancer research

open access: yesZhongguo aizheng zazhi
Phosphocreatine (PCr), traditionally recognized as an intracellular high-energy phosphate compound, mainly functions as a rapid energy buffer through the creatine kinase system to meet the high-energy demands of cells.
Haoxuan DONG   +3 more
doaj  

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová   +12 more
wiley   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

open access: yesThe FEBS Journal, Volume 293, Issue 12, Page 3485-3501, June 2026.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh   +2 more
wiley   +1 more source

Energy production pathways of female soccer players during championships: a metabolomics approach. [PDF]

open access: yesBraz J Med Biol Res
Nascimento MBA   +9 more
europepmc   +1 more source

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