Results 161 to 170 of about 31,996 (262)

High‐Resolution Imaging of Extracellular pH in Mouse Liver Tumor

open access: yesNMR in Biomedicine, Volume 39, Issue 9, September 2026.
High‐resolution imaging of extracellular pH (pHe) using 1H‐BIRDS with REduced Spherical Encoding with GAussian Weighting (RESEGAW) was achieved in an orthotopic mouse liver tumor (Hepa1–6) model and was validated with 31P MRSI using 3‐aminopropylphosphonate, showing excellent agreement between the two methods.
Jessica Gois Santana   +6 more
wiley   +1 more source

Quantitative assessment of cardiac phosphocreatine metabolism under physiological and pharmacological stress using chemical exchange saturation transfer magnetic resonance imaging. [PDF]

open access: yesJ Cardiovasc Magn Reson
Huang Q   +12 more
europepmc   +1 more source

Oxygenaging: A Physiological Framework for Geroscience

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
Mechanisms of aging disrupt oxygen homeostasis through three converging processes: oxygen‐cascade impairment, microvascular dysfunction, and molecular maladaptation. “Oxygenaging” integrates these domains to explain how declining oxygen delivery and utilization drive mitochondrial instability and amplify the effect of the hallmarks of aging.
Stefano Donega   +6 more
wiley   +1 more source

Aged Mitochondrial DNA Is Associated With Aberrant Acute Exercise‐Induced Redox Responses in Human Skeletal Muscle

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
Findings from this study suggest that aging is accompanied by altered skeletal muscle mitochondrial redox regulation and exercise responsiveness, with decreased mtDNA copy number, increased mtDNA mutation deletion frequency, and selective redox remodeling of key mitochondrial proteins representing potential contributors to these changes. ABSTRACT Redox
Bradley A. Ruple   +11 more
wiley   +1 more source

Quantifying skeletal muscle energy metabolism during exercise in heart failure with preserved ejection fraction using in vivo  31P magnetic resonance spectroscopy. [PDF]

open access: yesESC Heart Fail
Weerts J   +13 more
europepmc   +1 more source

Aging Alters Hair Cell Physiological Properties in Mice With Late‐Onset Age‐Related Hearing Loss

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
Hidden hearing loss during aging is associated with peripheral auditory system decline. We discovered that aging sensory hair cells decrease in size. In addition, inner hair cells exhibit a reduced K+ current carried out by BK channels, accompanied by an elevated resting membrane potential, suggesting an age‐related functional impairment.
Piece Yen   +5 more
wiley   +1 more source

Recent advances in phosphocreatine metabolism and its role in cancer research

open access: yesZhongguo aizheng zazhi
Phosphocreatine (PCr), traditionally recognized as an intracellular high-energy phosphate compound, mainly functions as a rapid energy buffer through the creatine kinase system to meet the high-energy demands of cells.
Haoxuan DONG   +3 more
doaj  

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