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On the mechanisms of neuroprotection by creatine and phosphocreatine
Journal of Neurochemistry, 2001Creatine and phosphocreatine were evaluated for their ability to prevent death of cultured striatal and hippocampal neurons exposed to either glutamate or 3‐nitropropionic acid (3NP) and to inhibit the mitochondrial permeability transition in CNS mitochondria. Phosphocreatine (PCr), and to a lesser extent creatine (Cr), but not (5R,10S)‐(+)‐5‐methyl‐10,
Nickolay Brustovetsky +2 more
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A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs
Medicinal Chemistry, 2018Adenosine triphosphate (ATP) is the energy currency of the body; it takes part in various and indispensable metabolic processes for the maintenance of cell homeostasis, degrading to its hydrolysis product, adenosine diphosphate (ADP). Efficient ways to restore ATP are therefore necessary in the cells.
Arkel, Maria +8 more
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A model for phosphocreatine resynthesis
Journal of Applied Physiology, 1997Nevill, Alan M., David A. Jones, David McIntyre, Gregory C. Bogdanis, and Mary E. Nevill. A model for phosphocreatine resynthesis. J. Appl. Physiol. 82(1): 329–335, 1997.—A model for phosphocreatine (PCr) resynthesis is proposed based on a simple electric circuit, where the PCr store in muscle is likened to the stored charge on the capacitor.
A M, Nevill +4 more
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The identification of phosphocreatine in liver
Biochimica et Biophysica Acta, 1951Abstract 1. 1. The nature of the acid-molybdate-labile P compound occurring in trichloracetic acid extracts of livers from guinea pigs treated with carbon tetrachloride has been investigated. 2. 2. On the basis of the P:creatine ratio, the neture and determination of the compounds liberated in the presence of acid-molybdate, and the behaviour
H, BARKER, A H, ENNOR
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Nature, 1947
IT is generally assumed that when phosphocreatine is hydrolysed either enzymatically or spontaneously, the end products are creatine and phosphoric acid. This, however, is not always found to be the case. When phosphocreatine is hydrolysed at 38° in saturated picric acid, about 10 percent of the substance is converted into creatinine (Fig. 1.).
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IT is generally assumed that when phosphocreatine is hydrolysed either enzymatically or spontaneously, the end products are creatine and phosphoric acid. This, however, is not always found to be the case. When phosphocreatine is hydrolysed at 38° in saturated picric acid, about 10 percent of the substance is converted into creatinine (Fig. 1.).
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A simple analysis of the "phosphocreatine shuttle"
American Journal of Physiology-Cell Physiology, 1984The diffusive mobility of solutes chemically connected by reversible reactions in cells is analyzed as a problem of facilitated diffusion. By this term we mean that the diffusive flux of any substance, X, which is in one metabolic pathway, is effectively increased when it participates in a second and equilibrium reaction with another substance Y ...
R A, Meyer +2 more
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Free and bound orthophosphate and phosphocreatine in muscle
Archives of Biochemistry and Biophysics, 1964Abstract The use of ethanol at low temperature as deproteinizing medium reveals the presence of some bound phosphocreatine as well as of bound Pi in resting muscle. The amount of bound Pi in muscles of frogs and rabbits is comparable to that bound by myosin isolated from these species, but the amount in cat muscles is significantly greater.
J, SACKS, R S, FULFORD
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Phosphocreatine resynthesis is not affected by creatine loading
Medicine & Science in Sports & Exercise, 1999Oral creatine supplementation has been shown to improve power output during high intensity intermittent muscle contractions. Facilitated muscle phosphocreatine (PCr) resynthesis, by virtue of elevated intracellular PCr concentration, might contribute to this ergogenic action. Therefore, the effect of creatine loading (C: 25 g X d(-1) for 5 d) on muscle
K, Vandenberghe +4 more
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Phosphocreatine as a Possible Modulator of the Adenylate Pool
1989The administration of purine nucleotide precursors results in a small increase of the adenylate pool because of feedback control mechanisms; nevertheless different tissues have different levels of the adenylate pool. This suggests that other factors may modulate the feedback regulation.
RONCA, GIOVANNI +5 more
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