Results 131 to 140 of about 31,996 (262)
Changes in ATP, phosphocreatine, and 16 metabolites in muscle stimulated for up to 96 hours
, 1996 Rabbit tibialis anterior muscles were stimulated continuously at 10 Hz for periods ranging from 2 min to 96 h and were analyzed for energy reserves and metabolic intermediates.
S. Salmons +6 more
core +1 more source
NMR in Biomedicine, Volume 39, Issue 10, October 2026.A single‐shot, multifrequency‐selective 1H‐MRS technique known as double Delays‐Alternating‐Nutation‐Tailored‐Excitation‐Point RESolved‐Spectroscopy (DANTE‐PRESS) can selectively refocus two frequencies of interest and simplify spectral modeling. ABSTRACT Glutamate and glutathione share a complex and tightly regulated cycle where imbalances can be a ...
Kesavi Kanagasabai +3 more
wiley +1 more source
NMR in Biomedicine, Volume 39, Issue 10, October 2026.Metabolomic profiling of breast cancer tissue using 1H HR‐MAS NMR spectroscopy and LCModel‐based quantitative analysis revealed metabolite differences associated with immunohistochemical subtypes, and subsequent metabolomics–transcriptomics integration linked these subtype‐dependent metabolic signatures to pathways in choline metabolism, one‐carbon ...
Irene Garcia‐Bocanegra +10 more
wiley +1 more source
Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework
Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley +1 more source
(Phospho)creatine: the reserve and merry-go-round of brain energetics
Neural Regeneration Research, 2023 Hong-Ru Chen, Ton DeGrauw, Chia-Yi Kuan
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5832-5853, October 2026.Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama +4 more
wiley +1 more source
Inositol pyrophosphate kinases in health and disease
FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing +6 more
wiley +1 more source
Management of Acute Colchicine Poisoning With Multiple Organ Dysfunction Syndrome: A Case Report
Clinical Case Reports, Volume 14, Issue 9, September 2026.ABSTRACT Colchicine is a microtubule‐disrupting alkaloid used in the treatment of gout and familial Mediterranean fever. It has a narrow therapeutic window, and overdose is associated with a high risk of fatal toxicity. Colchicine poisoning may initially present with gastrointestinal symptoms resembling acute gastroenteritis, which can make early ...
Jintao Luo +6 more
wiley +1 more source
European Journal of Sport Science, Volume 26, Issue 9, September 2026.ABSTRACT Inter‐set blood‐flow restriction (BFR) may increase the physiological stimulus of repeated‐sprint exercise without compromising mechanical output, but evidence in trained athletes is limited. In a randomized crossover design, 26 national‐level male badminton players completed three 5 × 5‐s cycling sprints (25‐s intra‐set rest, 3.5‐min inter ...
Tianhao Zheng +4 more
wiley +1 more source