Results 101 to 110 of about 93,838 (303)
Effect of phosphodiesterase inhibitors in the bladder
Asian Journal of Urology, 2015 Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cysteine/H2S pathway.
Aizaz Ali +3 more
openaire +4 more sources
Molecular Mechanisms of Phosphorus Metabolism and Transport during Leaf Senescence
Plants, 2015 Leaf senescence, being the final developmental stage of the leaf, signifies the transition from a mature, photosynthetically active organ to the attenuation of said function and eventual death of the leaf.
Kyla A. Stigter, William C. Plaxton
doaj +1 more source
Is zucchini a phosphodiesterase or a ribonuclease?
Biomedical Journal, 2014 Zucchini (Zuc), a member of the phospholipase D (PLD) superfamily, is essential for the primary PIWI-interacting RNA (piRNA) biogenesis and the suppression of transposon expression, which are crucial for the genome integrity of germline cells. However, it has been ambiguous whether Zuc acts as a phosphodiesterase to produce phosphatidic acid (PA), the ...
openaire +4 more sources
Unexpected Remyelination in the Absence of Matrix Metalloproteinase 7
Glia, EarlyView.MMP7 is not essential for demyelination and remyelination in the cuprizone model. In MMP7−/− mice fibronectin aggregates do not accumulate in the remyelination phase. MMP7−/− mice have lower levels of fibronectin and hyaluronan after chronic demyelination.
Rianne P. Gorter +7 more
wiley +1 more source
Glia, EarlyView.Inactivating the INO80 chromatin remodeling complex greatly extends the oligodendrocyte precursor (OP) cell cycle by prolonging G1. INO80 acts in OPs via histone H2A/H2A.Z exchange. INO80 binds the transcriptional regulator OLIG2 in OPs. ABSTRACT Chromatin remodeling complexes (CRCs) participate in oligodendrocyte (OL) differentiation, survival, and ...
Jordan L. Wright +4 more
wiley +1 more source
Traumatic brain injury upregulates phosphodiesterase expression in the hippocampus
Frontiers in Systems Neuroscience, 2016 Traumatic brain injury (TBI) results in significant impairments in hippocampal synaptic plasticity. A molecule critically involved in hippocampal synaptic plasticity, 3',5'-cyclic adenosine monophosphate (cAMP), is downregulated in the hippocampus after ...
Nicole M Wilson +4 more
doaj +1 more source
Glia, EarlyView.Ablation of autophagy in oligodendrocytes reveals increased PLP expression, myelin abnormalities, axon degeneration, and increased microglia activation in aged mice. The aged mice exhibit marked deficits in learning and memory tasks. ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying mechanisms ...
Niki Ktena +8 more
wiley +1 more source
Nucleotide exchange reactions catalysed by ribonuclease and spleen phosphodiesterase. 2. Synthesis of polynucleotides [PDF]
, 1955 L. A. Heppel +2 more
openalex +1 more source
Head &Neck, EarlyView.ABSTRACT Background The detection rate of oncogenic human papillomaviruses (HPVs) in sinonasal squamous cell carcinomas (SNSCCs) varies among studies. The mutational landscape of SNSCCs remains poorly investigated. Methods We investigated the prevalence and prognostic significance of HPV infections based on p16 protein expression, HPV‐DNA detection ...
Maxime Henrion +8 more
wiley +1 more source
Persistent pulmonary hypertension of the newborn
Journal of the Formosan Medical Association, 2013 Persistent pulmonary hypertension of the newborn (PPHN) is a severe pulmonary disorder which occurs at a rate of one in every 500 live births. About 10–50% of the victims will die of the problem and 7–20% of the survivors develop long-term impairments ...
Ru-Jeng Teng, Tzong-Jin Wu
doaj +1 more source