Results 131 to 140 of about 93,838 (303)

Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice

open access: yesAging Cell, EarlyView.
The diminished function of endothelial TRPV4, rather than changes in its expression, plays a significant role in aging‐related endothelial dysfunction. The interaction between TRPV4 and GPR35 significantly contributes to this condition. Blocking the TRPV4‐GPR35 interaction with Thonningianin A or Carfilzomib represents a promising precision approach ...
Xiaoxue Tian   +12 more
wiley   +1 more source

Effects of various straw incorporation strategies on soil phosphorus fractions and transformations

open access: yesGCB Bioenergy, Volume 15, Issue 1, Page 88-98, January 2023., 2023
Abstract Returning straw to the field is an effective method for optimizing the soil phosphorus (P) availability, in which bacteria play an important role. However, the effects of various straw incorporation strategies on P transformation between different soil P pools remain unclear.
Jiahui Pu   +5 more
wiley   +1 more source

An Update on Phosphodiesterase Mutations Underlying Genetic Etiology of Hearing Loss and Retinitis Pigmentosa

open access: yesFrontiers in Genetics, 2018
Rahul Mittal   +7 more
doaj   +1 more source

Positive Effects of Caffeine Therapy in a Girl with PDE2A‐Related Paroxysmal Dyskinesia

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Katerina Bernardi   +2 more
wiley   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

open access: yesAging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante   +24 more
wiley   +1 more source

Action of Venom Phosphodiesterase on Deoxyribonucleic Acid

open access: hybrid, 1961
Edward J. Williams   +2 more
openalex   +1 more source

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