Results 141 to 150 of about 225,115 (385)
ESC Heart Failure, EarlyView.Abstract Aims Renal impairment frequently coexists with heart failure (HF) and is associated with increased risk of poor clinical outcomes. This highlights the urgent need for therapies targeting both cardiac and renal dysfunction. AZD3427, a long‐acting recombinant fusion protein and relaxin analogue that selectively activates the relaxin family ...
Marcin Ufnal +9 more
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Pharmaceuticals, 2010 Theophylline (3-methyxanthine) has been used to treat airway diseases for over 70 years. It was originally used as a bronchodilator but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β2 ...
Peter J. Barnes
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Nucleotide exchange reactions catalysed by ribonuclease and spleen phosphodiesterase. 1. Synthesis and interconversion of simple esters of ribomononucleotides [PDF]
, 1955 L. A. Heppel, Paul R. Whitfeld
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Circulating oxylipins predict mortality in heart failure with preserved ejection fraction
ESC Heart Failure, EarlyView.A targeted LC–MS lipidomics approach identified arterial 15‐keto PGF2a as associated with 5‐year mortality in 90 patients with HFpEF. Abstract Aims Heart failure with preserved ejection fraction (HFpEF) poses significant diagnostic, prognostic and therapeutic challenges, with high morbidity and mortality rates.
Vaishnavi Aradhyula +12 more
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Frontiers in Microbiology, 2018 Cyclic dimeric adenosine 3′,5′-monophosphate (c-di-AMP), a recently identified secondary messenger in bacteria, plays a role in several bacterial processes, including biofilm formation. It is enzymatically produced by diadenylate cyclase and cleaved by c-
Hiroyasu Konno +5 more
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ESC Heart Failure, EarlyView.Among patients with ADHF‐related SCAI stage B CS enrolled in SEISMiC, istaroxime at doses up to 1.0 μg/kg/min for up to 60 h was associated with sustained improvements in aortic pulsatility index and LV stroke work index, and with increase of PA compliance and reduction in PA elastance at 48 h.
Matteo Pagnesi +21 more
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Kinetics of hydrolysis of uridylic oligonucleotides with different degree of polymerisation by snake venom phosphodiesterase [PDF]
, 1969 L.B. Dolapchiev
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European Journal of Heart Failure, EarlyView.The diagnosis of atrial cardiomyopathy (AtCM) requires electrical atrial dysfunction, with evidence of either mechanical atrial dysfunction, atrial enlargement, or excessive atrial fibrosis. The diagnostic cut‐points presented are for standard electrocardiogram and echocardiogram studies (see Figure 1 for further detail).
Jerremy Weerts +26 more
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Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?
British Journal of Pharmacology, EarlyView., 2023 Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
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Effects of Whole-body Irradiation and Radio-mimetic Chemicals on the Acid RNAse and Phosphodiesterase Levels of Rat Intestinal Homogenate [PDF]
, 1968 P.A. Gresham, W. F. R. Pover
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