Results 171 to 180 of about 229,722 (383)

Randomized Trial of Phosphodiesterase Inhibitors Versus Catecholamines in Patients With Acutely Decompensated Heart Failure.

, 2001
Akio Kawamura, Tsutomu Yoshikawa, Toshiyuki Takahashi, Takeharu Hayashi, Eiichi Takahashi, Toshihisa Anzai, Tôru Satô, Satoshi Ogawa   +7 more
openalex   +2 more sources

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

Journal of the American Medical Association (JAMA), 2013
M. Redfield, Horng H. Chen, B. Borlaug, M. Semigran, Kerry L Lee, G. Lewis, M. LeWinter, J. Rouleau, D. Bull, D. Mann, A. Deswal, L. Stevenson, M. Givertz, E. Ofili, C. O'connor, G. Felker, S. Goldsmith, B. Bart, S. McNulty, Jenny Ibarra, G. Lin, Jae K. Oh, M. Patel, R. Kim, R. Tracy, E. Velazquez, K. Anstrom, A. Hernandez, A. Mascette, E. Braunwald, for the RELAX Trial   +30 more
semanticscholar   +1 more source

Penile rehabilitation in men after radical robotic prostatectomy: Fact or fiction?

UroPrecision, EarlyView.
Abstract Erectile dysfunction (ED) is one of the most frequent and distressing complications after radical prostatectomy (RP), significantly impairing patients’ quality of life and intimate relationships. Penile rehabilitation (PR) aims to preserve erectile tissue integrity, prevent fibrosis, and facilitate early functional recovery by restoring ...
Karen Zhang, Arnold P. P. Achermann, Hunter Hasley, Richard Bennett, Andrew Guo, Mohammed Mahdi, Lucas G. C. R. de Amorim, Helen L. Bernie, Thairo A. Pereira   +8 more
wiley   +1 more source

Thyroid hormone control of cyclic nucleotide phosphodiesterases and the regulation of the sensitivity of the liver to hormones [PDF]

, 1977
K.A. Gumaa, John S. Hothersall, A. L. Greenbaum, Patricia McLean   +3 more
openalex   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, EarlyView.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Inhibitors of phosphodiesterase as cancer therapeutics.

European journal of medicinal chemistry, 2018
Ting Peng, J. Gong, Yongzhi Jin, Yanping Zhou, Rongsheng Tong, Xin Wei, Lan Bai, Jianyou Shi   +7 more
semanticscholar   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction

Circulation Research, 2017
C. Vettel, Marta Lindner, Matthias Dewenter, K. Lorenz, Constanze Schanbacher, Merle Riedel, Simon Lämmle, S. Meinecke, F. Mason, S. Sossalla, A. Geerts, Michael Hoffmann, F. Wunder, F. Brunner, T. Wieland, Hind Mehel, S. Karam, P. Lechène, J. Leroy, G. Vandecasteele, Michael Wagner, R. Fischmeister, A. El-Armouche   +22 more
semanticscholar   +1 more source

Treatment Satisfaction, Efficacy, and Safety of Delgocitinib Ointment Following Switch From Topical Corticosteroids for Trunk and Extremity Rash in Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent remissions and relapses. Topical anti‐inflammatory steroids are commonly used for treatment, but their long‐term use poses concerns because of potential side effects. Delgocitinib ointment, a Janus kinase inhibitor, has demonstrated efficacy in several clinical
Masatoshi Abe, Atsuyuki Igarashi, Hiroyuki Kitajima, Hiroyuki Toyama, Kenji Kabashima, Hidehisa Saeki   +5 more
wiley   +1 more source

Activation of Extracellular Signal-Regulated Kinase 5 Reduces Cardiac Apoptosis and Dysfunction via Inhibition of a Phosphodiesterase 3A/Inducible cAMP Early Repressor Feedback Loop

, 2007
Yan Chen, Bo Ding, Tetsuro Shishido, Chang-Hoon Woo, Seigo Itoh, Kye-Im Jeon, Weimin Liu, Haodong Xu, Carolyn McClain, Carlos A. Molina, Burns C. Blaxall, Jun‐ichi Abe   +11 more
openalex   +1 more source