Results 171 to 180 of about 225,115 (385)

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

Journal of the American Medical Association (JAMA), 2013
M. Redfield, Horng H. Chen, B. Borlaug, M. Semigran, Kerry L Lee, G. Lewis, M. LeWinter, J. Rouleau, D. Bull, D. Mann, A. Deswal, L. Stevenson, M. Givertz, E. Ofili, C. O'connor, G. Felker, S. Goldsmith, B. Bart, S. McNulty, Jenny Ibarra, G. Lin, J. Oh, M. Patel, R. Kim, R. Tracy, E. Velazquez, K. Anstrom, A. Hernandez, A. Mascette, E. Braunwald, for the RELAX Trial   +30 more
semanticscholar   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

Molecular Nutrition &Food Research, EarlyView.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska   +12 more
wiley   +1 more source

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, EarlyView.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Studies on 5'-Phosphodiesterases in Microorganisms

, 1959
Akira Kuninaka, SHIN-ICHIRÔ ÔTSUKA, Yasuo Kobayashi, Kinichirô SAKAGUCHI   +3 more
openalex   +2 more sources

Erectile and ejaculatory outcomes after holmium laser enucleation of the prostate: A comprehensive narrative review

UroPrecision, EarlyView.
ABSTRACT Holmium laser enucleation of the prostate (HoLEP) has emerged as a widely adopted surgical technique for the management of benign prostatic hyperplasia (BPH), regardless of prostate size; however, its impact on male sexual function—particularly in terms of erectile and ejaculatory outcomes—remains a subject of ongoing debate.
Muhammed Arif İbiş, Fabio Castiglione, Nawal Khan, Ömer Onur Çakır, Zafer Tokatlı, Önder Yaman   +5 more
wiley   +1 more source

Role of cAMP and phosphodiesterase signaling in liver health and disease.

Cellular Signalling, 2018
B. Wahlang, C. McClain, S. Barve, L. Gobejishvili   +3 more
semanticscholar   +1 more source

Treatment Satisfaction, Efficacy, and Safety of Delgocitinib Ointment Following Switch From Topical Corticosteroids for Trunk and Extremity Rash in Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent remissions and relapses. Topical anti‐inflammatory steroids are commonly used for treatment, but their long‐term use poses concerns because of potential side effects. Delgocitinib ointment, a Janus kinase inhibitor, has demonstrated efficacy in several clinical
Masatoshi Abe, Atsuyuki Igarashi, Hiroyuki Kitajima, Hiroyuki Toyama, Kenji Kabashima, Hidehisa Saeki   +5 more
wiley   +1 more source

Roflumilast for Oral Ulcers in Behçet's Disease and Recurrent Aphthous Stomatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Oral aphthous ulcer in Behçet's disease (BD) and recurrent aphthous stomatitis (RAS) is a cause of discomfort for many patients, especially in cases refractory to colchicine or azathioprine. Roflumilast, a phosphodiesterase‐4 (PDE4) inhibitor, may be effective for treating refractory oral ulcers (OUs) in BD and RAS, especially in regions where
Kyung Bae Chung, Hae June Sung, Eun Hye Kim, Hyunwoo Jang, Do‐Young Kim   +4 more
wiley   +1 more source

A Specific and Nonspecific Alkaline Monophosphatase in the Venom of Bothrops atrox and Their Occurrence in the Purified Venom Phosphodiesterase

, 1963
E. Sulkowski, Walter Björk, M. Laskowski   +2 more
openalex   +1 more source

Effect of Ca²⁺ on the stability of the protein activator of cyclic nucleotide phosphodiesterase [PDF]

, 1975

openalex   +1 more source