Results 181 to 190 of about 216,066 (333)

Engineering of a red-light–activated human cAMP/cGMP-specific phosphodiesterase

Proceedings of the National Academy of Sciences of the United States of America, 2014
C. Gasser, Sandra Taiber, Chen-Min Yeh, C. Wittig, P. Hegemann, S. Ryu, F. Wunder, Andreas Möglich   +7 more
semanticscholar   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

Associations between phosphodiesterase type 5 inhibitors and vascular function: a systematic review and meta-analysis on randomized-controlled trials. [PDF]

Syst Rev
Zhang Y, Peng H, Xin S, Mao J, Zhang J, Li H, Luan Y, Liu X, Wang T, Liu J, Zhang H, Song W.   +11 more
europepmc   +1 more source

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

Neurotherapeutics, 2014
M. Gurney, Emily C. D’Amato, A. Burgin
semanticscholar   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Exploration of the Role of Cilostazol in Brugada Syndrome: Mechanisms, Therapeutic Potential, and Implications in the Prevention of Ventricular Arrhythmias. [PDF]

Rev Cardiovasc Med
Iqbal M, Putra ICS, Karwiky G, Achmad C.
europepmc   +1 more source

Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation

The FEBS Journal, EarlyView.
The regulatory subunit RIβ of protein kinase A occurs in two variants that differ at residue 268 (A268 versus R268). This seemingly small substitution significantly changes cAMP sensitivity, basal kinase activity, and the dynamic behavior of the regulatory domains.
Maximilian Wallbott, Jui‐Hung Weng, Valeria Pane, Yuliang Ma, Jian Wu, Susan S. Taylor, Friedrich W. Herberg   +6 more
wiley   +1 more source

The c-di-AMP binding protein NadD from Mesomycoplasma ovipneumoniae functions as a phosphodiesterase that inhibits host inflammatory responses. [PDF]

Vet Res
Zhang Y, Xu Z, Li M, Hao X.
europepmc   +1 more source

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

British Journal of Pharmacology, 2012
T. Keravis, C. Lugnier
semanticscholar   +1 more source

A supramolecular assembly of cone‐specific G‐protein and cryptochrome 4a on lipid bilayer

The FEBS Journal, EarlyView.
Immobilized phospholipid bilayers on a sensor chip surface serve as membrane platform to investigate critical protein–lipid and protein–protein interaction processes by surface plasmon resonance. The putative magnetoreceptor cryptochrome 4a and the myristoylated cone‐specific G‐protein α‐subunit (Gtα) bind with high affinity to immobilized lipid ...
Ümmügülsüm Güzelsoy‐Flügge, Srđan Vujinović, Alexander Scholten, Karl‐Wilhelm Koch   +3 more
wiley   +1 more source