Results 211 to 220 of about 216,066 (333)

Transcriptional adapter ADA2 regulates yield and end‐use quality through liquid–liquid phase separation in wheat

Journal of Integrative Plant Biology, EarlyView.
The transcriptional adapter ADA2 interacts with the histone acetyltransferase GCN5 to regulate starch and storage protein content in wheat grains through histone acetylation. ADA2 undergoes phase separation and is modulated by GCN5, affecting histone acetyltransferase activity and gene transcription.
Xiaobang Zhang, Ruijie Zhang, Yuhan Zhang, Tao Yang, Longfei Wu, Yuan Cao, Jun Xiao, Jigang Li, Xin Gao, Xinyou Cao, Jie Liu, Mingming Xin, Yuan Zong, Zhongfu Ni, Qixin Sun, Yingyin Yao   +15 more
wiley   +1 more source

Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility

Circulation, 2007
Jayan Nagendran, S. Archer, Daniel Soliman, V. Gurtu, R. Moudgil, A. Haromy, Chantal N St Aubin, Linda Webster, I. Rebeyka, D. Ross, P. Light, J. Dyck, E. Michelakis   +12 more
semanticscholar   +1 more source

Comparative analysis of canonical and noncanonical rhodopsins in Amphidinium carterae and Karlodinium veneficum

Journal of Phycology, EarlyView.
Abstract Rhodopsins are ancient and versatile light‐sensitive proteins, widely distributed across microbial life. In dinoflagellates, however, their diversity and function remain poorly understood, owing to the lineage's extreme genomic divergence. Here, we surveyed the rhodopsin complements of two dinoflagellates, Amphidinium carterae and Karlodinium ...
Jens Wira, Miranda Judd, Anne Baldino, Tsvetan Bachvaroff, Allen R. Place   +4 more
wiley   +1 more source

The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Dyrkheeva NS, Chernyshova IA, Arutyunyan AF, Zakharenko AL, Kutuzov MM, Naumenko KN, Venzel AS, Ivanisenko VA, Deyev SM, Zhuze AL, Lavrik OI.   +10 more
europepmc   +1 more source

The Ubiquitous Protein Domain EAL Is a Cyclic Diguanylate-Specific Phosphodiesterase: Enzymatically Active and Inactive EAL Domains

Journal of Bacteriology, 2005
A. Schmidt, Dmitri A. Ryjenkov, M. Gomelsky   +2 more
semanticscholar   +1 more source

Targeted Alkaline Phosphatase Therapy Enhances Alveolar Bone Healing in X‐Linked Hypophosphatemia in Mice

Journal of Periodontal Research, EarlyView.
Effects of exogenous tissue‐nonspecific alkaline phosphatase (TNAP) were analyzed in the Hyp mouse model of X‐linked hypophosphatemia (XLH). Maxillary first molars were extracted from wild‐type (WT) and Hyp mice at 6 weeks, and collagen gel ± TNAP was placed in sockets. In one group of Hyp mice, submucosal injections of TNAP or saline were delivered at
Aonjittra Phanrungsuwan, Bella Donnelly, José Luis Millán, Brian L. Foster   +3 more
wiley   +1 more source

The treatment of bullous pemphigoid with topical roflumilast 0.3% cream case study. [PDF]

JAAD Case Rep
Domingues E.
europepmc   +1 more source

Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata, Teresa C. DeFrancesco, John D. Bonagura, Mark G. Papich   +3 more
wiley   +1 more source

Improved survival with phosphodiesterase-5 inhibitor use in men with male-predominant cancers: real-world large database study. [PDF]

Front Oncol
Uralov D, Harrington SR, Samarah H, Walia AS, Aweeda M, Mustafa MU, Kumar P, Briskin A, Jackson J, Mastrolonardo EV, Luginbuhl AJ.   +10 more
europepmc   +1 more source

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.

Cell, 2005
S. Lehnart, X. Wehrens, S. Reiken, Sunita Warrier, A. Belevych, R. Harvey, Wito Richter, S. Jin, M. Conti, A. Marks   +9 more
semanticscholar   +1 more source