Results 221 to 230 of about 229,722 (383)

Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons

HYPERTENSION, 2015
Dan Li, Chieh‐Ju Lu, G. Hao, Hannah Wright, L. Woodward, Kun Liu, E. Vergari, N. Surdo, N. Herring, M. Zaccolo, D. Paterson   +10 more
semanticscholar   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Effects of Rolipram, a Selective Inhibitor of Phosphodiesterase 4, on Hyperlocomotion Induced by Several Abused Drugs in Mice

, 2000
Tomohisa Mori, Jun Baba, Yasuyuki Ichimaru, Tsutomu Suzuki   +3 more
openalex   +1 more source

The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to γ Subunit of the Photoreceptor cGMP Phosphodiesterase [PDF]

, 1997
Amanda Lochhead, Elina Nekrasova, Vadim Y. Arshavsky, Nigel J. Pyne   +3 more
openalex   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Dyrkheeva NS, Chernyshova IA, Arutyunyan AF, Zakharenko AL, Kutuzov MM, Naumenko KN, Venzel AS, Ivanisenko VA, Deyev SM, Zhuze AL, Lavrik OI.   +10 more
europepmc   +1 more source

Engineering of a red-light–activated human cAMP/cGMP-specific phosphodiesterase

Proceedings of the National Academy of Sciences of the United States of America, 2014
C. Gasser, Sandra Taiber, Chen-Min Yeh, C. Wittig, P. Hegemann, S. Ryu, F. Wunder, Andreas Möglich   +7 more
semanticscholar   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Improved survival with phosphodiesterase-5 inhibitor use in men with male-predominant cancers: real-world large database study. [PDF]

Front Oncol
Uralov D, Harrington SR, Samarah H, Walia AS, Aweeda M, Mustafa MU, Kumar P, Briskin A, Jackson J, Mastrolonardo EV, Luginbuhl AJ.   +10 more
europepmc   +1 more source

Characterization of cGMP-specific phosphodiesterases (PDE) in erythroid cells and effects PDE inhibitors on the production of fetal hemoglobin

, 2006
Almeida, Camila Bononi de, 1980-
openalex   +1 more source