Results 21 to 30 of about 93,838 (303)
Simulations Suggest Pharmacological Methods for Rescuing Long-Term Potentiation [PDF]
Journal of Theoretical Biology, 7 Nov 2014, pp. 243-250, 2014 Congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie synaptic plasticity. For example, Rubinstein-Taybi syndrome (RTS) is due to a mutation in cbp, encoding the histone acetyltransferase CREB-binding protein (CBP).
arxiv +1 more source
The Phosphodiesterases in the Rat Pancreas [PDF]
European Journal of Biochemistry, 1970 The purification of two phosphodiesterases found in the rat pancreas is described. The phosphodiesterase I, an enzyme of the snake venom type, has been purified about 500 times, the phosphodiesterase II, an enzyme of the spleen type, about 60 times. The phosphodiesterase I activity, optimal at a pH of about 9.0, is completely dependent on the presence ...
Cees Poort, W. J. Van Venrooij
openaire +3 more sources
Retinal regions shape human and murine Müller cell proteome profile and functionality
Glia, Volume 71, Issue 2, Page 391-414, February 2023., 2023 Main Points We defined Müller cells heterogeneity in the macular and peripheral human retina. Signaling pathways shaping this glial heterogeneity include proteins important for interaction with vesicular secretion, extracellular matrix and cell adhesion.
Lew Kaplan +15 more
wiley +1 more source
mBio, 2018 Pseudomonas fluorescens and related plant root (“rhizosphere”)-associated species contribute to plant health by modulating defenses and facilitating nutrient uptake.
Zhexian Liu +9 more
doaj +1 more source
Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis
Frontiers in Molecular Biosciences, 2023 Acrodysostosis represents a group of rare genetic disorders characterized by defective skeletal development and is often accompanied by intellectual disabilities.
Varun Venkatakrishnan +4 more
doaj +1 more source
BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation
mBio, 2017 The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria.
Ricardo N. Moreira +6 more
doaj +1 more source
Microorganisms, 2023 Cyclic di-adenosine monophosphate (c-di-AMP) is a bacterial second messenger discovered in Bacillus subtilis and involved in potassium homeostasis, cell wall maintenance and/or DNA stress response.
Sebastian J. Reich +5 more
doaj +1 more source
Spontaneous center formation in Dictyostelium discoideum [PDF]
Scientific reports 9, no. 1 (2019): 3935, 2018 Dictyostelium discoideum (D.d.) is a widely studied amoeba due to its capabilities of development, survival, and self-organization. During aggregation it produces and relays a chemical signal (cAMP) which shows spirals and target centers. Nevertheless, the natural emergence of these structures is still not well understood.
arxiv +1 more source
Frontiers in Earth Science, 2016 Atmospheric nutrient deposition and climate change are expected to endanger the diversity of tropical forest ecosystems. Nitrogen (N) deposition might influence nutrient fluxes beyond the N cycle by a concomitant increased demand for other nutritional ...
Karla eDietrich +2 more
doaj +1 more source
eLife, 2023 For decades, studies of snake venoms focused on the venom-ome-specific toxins (VSTs). VSTs are dominant soluble proteins believed to contribute to the main venomous effects and emerged into gene clusters for fast adaptation and diversification of snake ...
Cheng-Tsung Pan +6 more
doaj +1 more source