Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae
Frontiers in Microbiology, 2017 Bacteria often use cyclic dinucleotides as second messengers for signal transduction. While the classical molecule c-di-GMP is involved in lifestyle selection, the functions of the more recently discovered signaling nucleotide cyclic di-AMP are less ...
Cedric Blötz +5 more
doaj +1 more source
Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]
, 1985 The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina, +8 more
core +2 more sources
The Phosphodiesterases in the Rat Pancreas [PDF]
European Journal of Biochemistry, 1970 The purification of two phosphodiesterases found in the rat pancreas is described. The phosphodiesterase I, an enzyme of the snake venom type, has been purified about 500 times, the phosphodiesterase II, an enzyme of the spleen type, about 60 times. The phosphodiesterase I activity, optimal at a pH of about 9.0, is completely dependent on the presence ...
Cees Poort, W. J. Van Venrooij
openaire +3 more sources
Neurology, 2019 Objective To describe a novel antibody biomarker of neurologic paraneoplastic autoimmunity specific for phosphodiesterase 10A (PDE10A), a striatum-enriched phosphodiesterase, and to characterize the clinical phenotype of patients with PDE10A ...
Anastasia Zekeridou +7 more
semanticscholar +1 more source
Frontiers in Microbiology, 2016 Cyclic diguanylate (c-di-GMP) is essential for Yersinia pestis biofilm formation, which is important for flea-borne blockage-dependent plague transmission.
Gai-Xian eRen +4 more
doaj +1 more source
Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity [PDF]
, 2016 Phosphodiesterase (PDE) inhibitors are currently under evaluation as agents that may facilitate the improvement of cognitive impairment associated with Alzheimer's disease. Our aim was to determine whether inhibitors of PDEs 4,5 and 9 could alleviate the
Baillie, George S. +4 more
core +1 more source
BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation
mBio, 2017 The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria.
Ricardo N. Moreira +6 more
doaj +1 more source
Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression [PDF]
, 2015 background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome.
Baillie, G. S. +12 more
core +1 more source
Targeting Phosphodiesterases—Towards a Tailor-Made Approach in Multiple Sclerosis Treatment
Frontiers in Immunology, 2019 Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) characterized by heterogeneous clinical symptoms including gradual muscle weakness, fatigue, and cognitive impairment.
Melissa Schepers +15 more
doaj +1 more source
Molecules, 2022 Extracts from Drosera rotundifolia are traditionally used to treat cough symptoms during a common cold. The present study aimed to investigate the impact of extracts from D. rotundifolia and active compounds on the respiratory tract.
Alexander Hake +5 more
doaj +1 more source