Results 41 to 50 of about 229,722 (383)
Influence of metabolism modifiers of cyclic nucleotides on contractility of right ventricle of rat heart with intact and removed endocardial endothelium [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2010 Introduction. Endocardial endothelium, a natural biological barrier between circulating blood in heart ventricle and cells, creates a complex yet finely tuned balance of interactions with the immediate environment. Objective. We investigated the roles
Savić Slađana +5 more
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Frontiers in Cellular and Infection Microbiology, 2023 The second messenger molecule, c-di-AMP, plays a critical role in pathogenesis and virulence in S. pyogenes. We previously reported that deleting the c-di-AMP phosphodiesterase gene pde2 severely suppresses SpeB production at the transcriptional level ...
Sabrina Faozia +2 more
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Mutations in phosphodiesterase 6 identified in familial cases of retinitis pigmentosa. [PDF]
, 2016 To delineate the genetic determinants associated with retinitis pigmentosa (RP), a hereditary retinal disorder, we recruited four large families manifesting cardinal symptoms of RP. We localized these families to regions on the human genome harboring the
Akram, Javed +9 more
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British Journal of Dermatology, 2015 Apremilast, an oral phosphodiesterase 4 inhibitor, regulates immune responses associated with psoriasis.
Carle Paul +12 more
semanticscholar +1 more source
Memory Enhancers for Alzheimer’s Dementia: Focus on cGMP
Pharmaceuticals, 2021 Cyclic guanosine-3′,5′-monophosphate, better known as cyclic-GMP or cGMP, is a classical second messenger involved in a variety of intracellular pathways ultimately controlling different physiological functions.
Ernesto Fedele, Roberta Ricciarelli
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Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system [PDF]
, 1981 The cyclic AMP and cyclic GMP phosphodiesterase activities present in flies of six mutant strains of the dunce gene and in the parent wild- type strains are characterized. All of the mutants exhibit aberrant cyclic AMP metabolism.
Davis, Ronald L., Kiger, John A., Jr.
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Scientific Reports, 2017 α-synuclein-induced neurotoxicity is a core pathogenic event in neurodegenerative synucleinopathies such as Parkinson’s disease, dementia with Lewy bodies, or multiple system atrophy.
M. Höllerhage +10 more
semanticscholar +1 more source
Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments
Journal of Cardiovascular Development and Disease, 2018 Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity,
Sofya Pozdniakova, Yury Ladilov
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Toxins, 2023 Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases.
Isadora Oliveira +8 more
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Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates [PDF]
, 2016 Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was
Alagille, David +10 more
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