Results 71 to 80 of about 93,838 (303)
Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells
Physiological Reports, 2020 Phosphodiesterase 3 (PDE3), of which there are two isoforms, PDE3A and PDE3B, hydrolyzes cAMP and cGMP—cyclic nucleotides important in the regulation of pulmonary vascular tone.
Julie Dillard +4 more
doaj +1 more source
Improving Memory: A Role for Phosphodiesterases [PDF]
Current Pharmaceutical Design, 2006 During the last decennia, our understanding of the neurobiological processes underlying learning and memory has continuously improved, leading to the identification of targets for the development of memory-enhancing drugs. Here we review a class of drugs which has more recently been identified: the phosphodiesterase (PDE) inhibitors.
Jos Prickaerts +2 more
openaire +4 more sources
Drug Testing and Analysis, EarlyView.This study reports the qualitative and quantitative detection of anabolic‐androgenic steroids (AASs) in seized samples from prisons. Since 2022 there has been an increase in AAS detections with oxymetholone the most prevalent AAS, followed by metandienone, methyltestosterone, and oxandrolone.
Caitlyn Norman +4 more
wiley +1 more source
Effects of diet and antihyperglycemic drugs on erectile dysfunction: A systematic review
Andrology, Volume 11, Issue 2, Page 282-294, February 2023., 2023 Abstract Background Erectile dysfunction is recognized as one of the complications of diabetes mellitus. To date, a wide gap of knowledge is present on the efficacy of pharmacological treatments of diabetes mellitus on erectile function, acting not only through metabolic control. Similarly, the effects of different diet regimens on erectile dysfunction
Giuseppe Defeudis +8 more
wiley +1 more source
Mammalian Glycerophosphodiester Phosphodiesterases [PDF]
Bioscience, Biotechnology, and Biochemistry, 2007 Bacterial glycerophosphodiester phosphodiesterases (GP-PDEs), GlpQ and UgpQ, are well-characterized periplasmic and cytosolic proteins that play critical roles in the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol, which are utilized as major sources of carbon and phosphate.
openaire +3 more sources
Alterations of Phosphodiesterases in Adrenocortical Tumors [PDF]
Frontiers in Endocrinology, 2016 Alterations in the cyclic (c)AMP-dependent signaling pathway have been implicated in the majority of benign adrenocortical tumors (ACTs) causing Cushing syndrome (CS). Phosphodiesterases (PDEs) are enzymes that regulate cyclic nucleotide levels, including cyclic adenosine monophosphate (cAMP).
Constantine A. Stratakis +2 more
openaire +4 more sources
Vericiguat improves cardiac remodelling and function in rats with doxorubicin‐induced cardiomyopathy
ESC Heart Failure, EarlyView.Abstract Purpose Vericiguat, a soluble guanylate cyclase (sGC) stimulator, has been demonstrated effective in improving prognosis of patients with heart failure with reduced ejection fraction. However, there are limited data concerning the effect of vericiguat in patients with doxorubicin (DOX)‐induced cardiomyopathy (DIC).
Wen Chen +6 more
wiley +1 more source
Andrology, Volume 11, Issue 2, Page 358-371, February 2023., 2023 Abstract Background The incidence of diabetic erectile dysfunction (ED) is rapidly increasing, and due to the severe angiopathy caused by diabetes, current drugs are ineffective at treating ED. Insulin‐like growth factor‐binding protein 5 (IGFBP5) promotes cell death and induces apoptosis in various cell types.
Jiyeon Ock +5 more
wiley +1 more source
Bayesian analysis of longitudinal studies with treatment by indication [PDF]
arXiv, 2019 It is often of interest in observational studies to measure the causal effect of a treatment on time-to-event outcomes. In a medical setting, observational studies commonly involve patients who initiate medication therapy and others who do not, and the goal is to infer the effect of medication therapy on time until recovery, a pre-defined level of ...
arxiv
Poor communication impairs optimal care of patients with heart failure and erectile dysfunction
ESC Heart Failure, EarlyView.Abstract Aims Heart failure (HF) and erectile dysfunction (ED) share numerous risk factors and pathogenetic mechanisms, resulting in a high prevalence of ED among male patients with HF. This questionnaire‐based study aimed to better understand the patient's journey from a patient perspective and that of healthcare professionals (HCPs) regarding ...
Lea Leist, Lenka Hausmann, Carla Pohlink
wiley +1 more source