Results 71 to 80 of about 225,115 (385)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

Mechanisms involved in the remyelinating effect of sildenafil [PDF]

, 2018
Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela, García, Agustina, Gutierrez-Mecinas, María, Martínez-Sánchez, José Lupicinio, Moreno, Beatriz, Pifarré, Paula   +5 more
core   +1 more source

Phosphodiesterase 3A and Arterial Hypertension [PDF]

Circulation, 2020
Background: High blood pressure is the primary risk factor for cardiovascular death worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt-resistant essential hypertension and causes death by stroke before 50 years of age. We recently implicated the gene encoding phosphodiesterase
Hanna Napieczynska, Michael Russwurm, Martin Lehmann, Astrid Mühl, Yingqiu Cui, Sofia K. Forslund, Stefanie Schelenz, Kerstin Zühlke, Rosana Molé Illas, Reika Langanki, Russell Hodge, Stephan Walter, Theda U P Bartolomaeus, Theda U P Bartolomaeus, Carolin Schächterle, Burkhard Wiesner, Nerine Gregersen, Sylvia Bähring, Ilona Kamer, Maria Ercu, Mihail Todiras, Friedrich C. Luft, Dmitry Tsvetkov, Arnd Heuser, Bärbel Pohl, Ralph Plehm, Elena Popova, Martin Taube, Jenny Eichhorst, Maik Gollasch, Maik Gollasch, Maik Gollasch, Fatimunnisa Qadri, Lajos Markó, Lajos Markó, Enno Klussmann, Michael Bader, Michael Bader, Yoland-Marie Anistan, Norbert Hubner, Norbert Hubner, Andrea Geelhaar, Sara Maghsodi, Atakan Aydin, Dominik N. Müller, Philipp G. Maass   +45 more
openaire   +3 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Characterization of Resveratrol, Oxyresveratrol, Piceatannol and Roflumilast as Modulators of Phosphodiesterase Activity. Study of Yeast Lifespan

Pharmaceuticals, 2020
Our desire to live longer has led to an ever-increasing number of novel antiaging products. However, few molecules have any real effect and new ones need to be studied before they can be used commercially.
Adrián Matencio, Francisco García-Carmona, José Manuel López-Nicolás   +2 more
doaj   +1 more source

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk

Frontiers in Pharmacology, 2021
3′,5′-cyclic adenosine monophosphate (cAMP) is well-known for its diverse immunomodulatory properties, primarily inhibitory effects during T cell activation, proliferation, and production of pro-inflammatory cytokines.
Roberta Kurelic, Paula F. Krieg, Jana K. Sonner, Gloria Bhaiyan, Gustavo C. Ramos, Gustavo C. Ramos, Stefan Frantz, Stefan Frantz, Manuel A. Friese, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +10 more
doaj   +1 more source

Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization [PDF]

, 2017
PURPOSE: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference.
Aversa, Antonio, Bimonte, VIVIANA MARIA, Crescioli, Clara, Di Luigi, Luigi, Fittipaldi, Simona, Francomano, Davide, Greco, Emanuela A., Lenzi, Andrea, Migliaccio, Silvia   +8 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

eLife, 2017
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome.
Yize Li, Shuvojit Banerjee, Stephen A Goldstein, Beihua Dong, Christina Gaughan, Sneha Rath, Jesse Donovan, Alexei Korennykh, Robert H Silverman, Susan R Weiss   +9 more
doaj   +1 more source