Results 121 to 130 of about 12,220,634 (288)
iNew Medicine, EarlyView.Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley +1 more source
iNew Medicine, EarlyView.Therapeutic mechanism, clinical efficacy and future directions for nerandomilast in pulmonary fibrosis. ABSTRACT The recent Phase III FIBRONEER trials establish nerandomilast, a novel oral phosphodiesterase 4B (PDE4B) inhibitor, as an effective therapy for idiopathic and progressive pulmonary fibrosis. By elevating cyclic adenosine monophosphate (cAMP),
Qianwen Bai +4 more
wiley +1 more source
PENGARUH PEMBERIAN PHOSPHODIESTERASE TYPE 5 INHIBITORS PADA TIKUS SPRAGUE DAWLEY JANTAN YANG DILAKUKAN TINDAKAN TORSI-DETORSI TESTIS [PDF]
, 2015 Background: Testicular torsion is an emergency that needs to be treated less than 6 hours (golden period) to prevent further tissue damage permanently.
Prasetyo, Agung Aji +2 more
core +1 more source
Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal +2 more
wiley +1 more source
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner +10 more
wiley +1 more source
Use of phosphodiesterase 5 inhibitors is not associated with ocular adverse events. [PDF]
J Sex Med, 2023 Belladelli F +11 more
europepmc +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Right ventricular (RV) to left ventricular (LV) end‐diastolic volume ratio (RV/LV) is a validated marker of RV dilation in pulmonary arterial hypertension (PAH), yet its impact on LV myocardial function and the underlying mediating pathway is incompletely characterized.
Han Fang +11 more
wiley +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Biologics and Janus kinase (JAK) inhibitors have transformed the management of atopic dermatitis (AD), yet some patients experience early worsening of disease activity during treatment initiation. In clinical trials, these events are typically recorded as treatment‐emergent adverse events (TEAEs), most commonly coded as “atopic dermatitis”. We
Diego Ruiz Dasilva +17 more
wiley +1 more source
Advances in the treatment of Raynaud’s phenomenon
Vascular Health and Risk Management, 2010 Terri L LevienDrug Information Pharmacist and Clinical Associate Professor, College of Pharmacy, Washington State University Spokane, WA, USAAbstract: Raynaud’s phenomenon is a common condition characterized by vasospasm of the digital arteries
Terri L Levien
doaj
Phosphodiesterase 5 inhibitors (PDE5i) for the treatment of Raynaud's phenomenon. [PDF]
Cochrane Database Syst Rev, 2023 Maltez N +8 more
europepmc +1 more source