Results 131 to 140 of about 46,730 (243)

In Salmonella Typhimurium, YiiD Modulates cAMP Levels in Lag Phase During Growth on Succinate

open access: yesMolecular Microbiology, EarlyView.
The YiiD enzyme, found by others to perform a redundant role in fatty acid biosynthesis, is found to be unexpectedly required for the early increase in cAMP in lag phase during growth on succinate. This intriguing finding suggests a mechanistic link may exist between fatty acid biosynthesis and catabolite repression. ABSTRACT In Salmonella Typhimurium (
John A. Ciemniecki   +2 more
wiley   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

open access: yesMolecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan   +2 more
wiley   +1 more source

Exploring patient preferences regarding the use of combination therapy with endothelin receptor antagonist (ERA) + phosphodiesterase-5 inhibitors (PDE5i). [PDF]

open access: yesJHLT Open
Kolaitis NA   +11 more
europepmc   +1 more source

Contribution of sewage to occurrence of phosphodiesterase-5 inhibitors in natural water. [PDF]

open access: yesSci Rep, 2021
Hong Y   +6 more
europepmc   +1 more source

2. Phosphodiesterase-5 Inhibitors.

open access: yesNihon Naika Gakkai Zasshi, 2010
Kimura, Hiroshi, Hamada, Kaoru
openaire   +2 more sources

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

open access: yesMolecular Microbiology, EarlyView.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh   +2 more
wiley   +1 more source

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