Results 151 to 160 of about 79,696 (205)

[Phosphodiesterase 5 inhibitors for the treatment of heart failure: a systematic review and meta-analysis]. [PDF]

Arch Cardiol Mex
Monzón-Herrera R, Listorti F, Vensentini N, Mariani J.   +3 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

In Defense of Phosphodiesterase 5 Inhibitors

JAMA Ophthalmology, 2022
Not ...
Belladelli, Federico, Del Giudice, Francesco, Eisenberg, Michael L   +2 more
openaire   +3 more sources

Phosphodiesterase-5 Inhibitors: Future Perspectives

Current Pharmaceutical Design, 2009
PDE-5 inhibitors were originally studied in cardiovascular indications but were later developed and approved for on-demand treatment of erectile dysfunction (ED). A few years ago sildenafil was approved for the treatment of pulmonary hypertension, thus renewing interest in cardiovascular applications, and tadalafil became available in once-daily ...
Giannitsas, Konstantinos, Perimenis, Petros   +1 more
openaire   +2 more sources

Phosphodiesterase-5 Inhibitors

2013
Nitric oxide (NO) signaling plays a key role in modulating vascular tone and remodeling in the pulmonary circulation. The guanylate cyclase/cyclic guanylate monophosphate-signaling pathway primarily mediates nitric oxide signaling. This pathway is critical in normal regulation of the pulmonary vasculature, and is an important target for therapy in ...
Barbara A, Cockrill, Aaron B, Waxman
openaire   +2 more sources

Phosphodiesterase 5 Inhibitors from Derris scandens

Planta Medica, 2018
AbstractPhosphodiesterase 5 inhibitors have been used as a first-line medicine for the treatment of erectile dysfunction. In the search for new phosphodiesterase 5 inhibitors from natural sources, we found that the 95% ethanol extract of Derris scandens stem showed phosphodiesterase 5 inhibitory activity with an IC50 value of about 7 µg/mL.
Nattiya, Chaichamnong, Prapapan, Temkitthawon, Nantaka, Khorana, Prompan, Pitpakdeeanan, Pornnarin, Taepavarapruk, Nitra, Nuengchamnong, Yuthana, Siriwattanasathien, Apichart, Suksamrarn, Kornkanok, Ingkaninan   +8 more
openaire   +2 more sources

Reno-protective effects of Phosphodiesterase 5 inhibitors

Clinical and Experimental Nephrology, 2021
The kidneys are vital organs that play an important role in removing waste materials from the blood, electrolyte balance, blood pressure regulation, and red blood cell genesis. Kidney disease can be caused by various factors, including diabetes, ischemia/reperfusion injury, and nephrotoxic agents.
Enis Rauf Coskuner, Burak Ozkan
openaire   +2 more sources

Phosphodiesterase Type 5 (PDE5) Inhibitors

2003
Publisher Summary In recent years, the field of Phosphodiesterase Type 5 (PDE5) inhibitors has reached a state of maturity. Standard issues in medicinal chemistry, such as potency, selectivity, physico-chemical properties and oral bioavailability, have been successfully addressed with the known PDE5 inhibitors.
Helmut, Haning, Ulrich, Niewöhner, Erwin, Bischoff   +2 more
openaire   +2 more sources

ADMET considerations for phosphodiesterase-5 inhibitors

Expert Opinion on Drug Metabolism & Toxicology, 2012
ADMET (absorption, distribution, metabolism, excretion, and toxicity) profiling is an important aspect of all drug developments. The pharmaceutical industry must always consider ADMET properties in order to optimize drug candidates and to introduce new formulations against existing marketed drugs.
Mohammad Amin, Rezvanfar, Hamid Reza, Rahimi, Mohammad, Abdollahi   +2 more
openaire   +2 more sources