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Phosphodiesterase Type 5 Inhibitors: Unmet Needs
Current Pharmaceutical Design, 2009Erectile dysfunction (ED) has been revolutionized during the last two decades, as several treatment options are available today. Phosphodiesterase type 5 (PDE5) inhibitors (sildenafil, tadalafil, vardenafil) are currently the first choice treatment option for ED by most physicians and patients due to their high efficacy rates and favourable safety ...
K, Hatzimouratidis, D G, Hatzichristou
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Cardiovascular Effects of Phosphodiesterase 5 Inhibitors
Current Pharmaceutical Design, 2006Phosphodiesterase 5 inhibitors, such as sildenafil, vardenafil and tadalafil, are now approved for the treatment of erectile dysfunction. They inhibit the cGMP-specific isoform 5 of phosphodiesterase, resulting in cGMP accumulation, which, for example in smooth muscle cells, reduces muscular tone.
Thorsten, Reffelmann, Robert A, Kloner
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Phosphodiesterase 5 Inhibitors for Erectile Dysfunction
Annals of Pharmacotherapy, 2005OBJECTIVETo review the pharmacologic and clinical trial data of the Food and Drug Administration–approved phosphodiesterase 5 (PDE5) inhibitors for the treatment of erectile dysfunction (ED).DATA SOURCESPrimary research and review articles were identified through a search of ScienceDirect, PubMed/MEDLINE, and International Pharmaceutical Abstracts ...
Stephen M, Setter +4 more
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Phosphodiesterase Type 5 Inhibitors: The Day After
European Urology, 2007Review the literature on phosphodiesterase type 5 inhibitors (PDE5-Is), addressing critical issues in their current and future use, assessing unanswered questions, and identifying research needs.A MEDLINE search was conducted on PDE5-Is, with emphasis on clinical trials and experience, for interpretation and analysis of their present and future role ...
Konstantinos, Hatzimouratidis +1 more
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Effect of phosphodiesterase-5 inhibitor on hearing
The Journal of Laryngology & Otology, 2009AbstractObjective:Following a report of sudden hearing loss in a patient taking phosphodiesterase type 5 inhibitor, and a Food and Drug Administration announcement concerning this class of drugs, a study was planned to investigate if ototoxicity occurs in patients using phosphodiesterase 5 inhibitor for erectile dysfunction.Methods:Eighteen patients ...
S, Okuyucu +4 more
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Phosphodiesterase type 5 inhibitors for erectile dysfunction
BJU International, 2005This is our first presentation of Great Drug Classes, and we start with a description of phosphodiesterase type 5 inhibitors and their use in erectile dysfunction. This is an in‐depth review of this class of drugs, offering the reader a description of how they work, in which conditions they may be particularly beneficial, and a ...
Culley C, Carson, Tom F, Lue
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Key Features for Designing Phosphodiesterase-5 Inhibitors
Journal of Biomolecular Structure and Dynamics, 2010Phosphodiesterase superfamily is the key regulator of 3',5'-cyclic guanosine monophosphate (cGMP) decomposition in human body. Phosphodiesterase-5 (PDE-5) inhibitors, sildenafil, vardenafil and tadalafil, are well known oral treatment for males with erectile dysfunction.
Tung-Ti, Chang +7 more
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Chapter 5. Phosphodiesterase 4 inhibitors
2001Publisher Summary This chapter describes the various aspects of phosphodiesterase 4 (PDE4) inhibitors. PDE4 is the predominant isozyme present in inflammatory cells and selective PDE4 inhibitors are a popular target for novel anti-inflammatory drugs. The distribution of PDE4 in inflammatory cells and airway smooth muscle, and the effects of selective
John G. Montana, Hazel J. Dyke
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A chemometric study of phosphodiesterase 5 inhibitors
Journal of Molecular Graphics and Modelling, 2006This work presents a chemometric classification for a set of phosphodiesterase 5 inhibitors, based on a pattern recognition method widely used in quantitative structure-activity (QSAR) studies, hierarchical cluster analysis (HCA) and principal component analysis (PCA), aiming to access the most relevant structural and physicochemical variables related ...
Luciana Jansen, de O Figueiredo +4 more
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Design of Second Generation Phosphodiesterase 5 Inhibitors
Current Topics in Medicinal Chemistry, 2007The clinical significance of phosphodiesterase 5 (PDE5) inhibition is increasingly understood following the pioneering work with sildenafil, and the continuing development programmes for both sildenafil and other marketed inhibitors. Since the initial launch of sildenafil for male erectile dysfunction (MED), approval has now been granted for treatment ...
Michael J, Palmer +3 more
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