Results 161 to 170 of about 46,730 (243)

The effectiveness of psychological interventions alone, or in combination with phosphodiesterase-5 inhibitors, for the treatment of erectile dysfunction:A systematic review. [PDF]

Arab J Urol, 2021
Atallah S, Haydar A, Jabbour T, Kfoury P, Sader G.   +4 more
europepmc   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Prognosis and Treatment With Phosphodiesterase 5 Inhibitors in Combined Post- and Precapillary Pulmonary Hypertension: A Propensity Score-Matched Analysis From the Hellenic Pulmonary Hypertension Registry. [PDF]

Pulm Circ
Papadopoulos GE, Arvanitaki A, Mouratoglou SA, Gourgiotis P, Chrysochoidis-Trantas T, Mpatsouli A, Bechlioulis A, Naka A, Demerouti E, Karyofyllis P, Tsiapras D, Anthi A, Manginas A, Ziakas A, Rosenkranz S, Giannakoulas G.   +15 more
europepmc   +1 more source

Radiation dose optimization in coronary CT angiography clinical application of absolute phase gating in patients with atrial fibrillation

Journal of Applied Clinical Medical Physics, Volume 27, Issue 7, July 2026.
Abstract Background Atrial fibrillation (AF) poses significant challenges for coronary CT angiography (CCTA) due to R‐R interval variability, often necessitating high radiation dose protocols. Absolute phase gating, which uses fixed millisecond delays rather than percentage‐based cardiac cycle timing, may optimize image quality while reducing radiation
Yuyang Li
wiley   +1 more source

Risk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US.

JAMA Ophthalmol, 2022
Etminan M, Sodhi M, Mikelberg FS, Maberley D.   +3 more
europepmc   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK Pathways

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1535-1553, July 2026.
Objective Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Phosphodiesterase-5 inhibitors use and the risk of alzheimer's disease: a systematic review and meta-analysis. [PDF]

Neurol Sci
Abouelmagd ME, Abdelmeseh M, Elrosasy A, Saad YH, Alnajjar AZ, Eid M, Hassan A, Abbas A.   +7 more
europepmc   +1 more source

Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer's disease. [PDF]

Biochem Pharmacol, 2020
Zuccarello E, Acquarone E, Calcagno E, Argyrousi EK, Deng SX, Landry DW, Arancio O, Fiorito J.   +7 more
europepmc   +1 more source

Phosphodiesterase-5 inhibitors for colon cancer chemoprevention

Aging, 2018
Islam, Bianca N., Browning, Darren D.
openaire   +2 more sources