Results 221 to 230 of about 47,423 (289)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Phosphodiesterase Type 5 Inhibitors and COVID-19: Are They Useful In Disease Management?

The World Journal of Men's Health, 2020
Nicola Mondaini
doaj   +1 more source

Phosphodiesterase-5 Inhibitors and Dementia Risk: A Real-World Study.

Neuroepidemiology
Gronich N, Stein N, Saliba W.
europepmc   +1 more source

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, Volume 49, Issue 3, Page 1598-1616, March 2026.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source

The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS). [PDF]

Mol Cell Biochem
AlRuwaili R, Al-Kuraishy HM, Alruwaili M, Khalifa AK, Alexiou A, Papadakis M, Saad HM, Batiha GE.   +7 more
europepmc   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, Volume 13, Issue 8, 9 February 2026.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source

Additional file 5 of The c-di-AMP binding protein NadD from Mesomycoplasma ovipneumoniae functions as a phosphodiesterase that inhibits host inflammatory responses

Ying Zhang, Zhaokun Xu, Min Li, Xiujing Hao   +3 more
openalex   +1 more source

Effect of platelet aggregation inhibitors on purified human platelet cyclic 3’:5’-nucleotide phosphodiesterase

, 1976
Tomiko Asano, Yasuo Ochiai, Hiroyoshi Hidaka   +2 more
openalex   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Efficacy and safety of on-demand dapoxetine combined with phosphodiesterase-5 inhibitor compared to monotherapy dapoxetine as a treatment of premature ejaculation without erectile dysfunction: a systematic review and meta-analysis

Ida Bagus Gde Ananta Mahesvara, I Wayan Suarsana, Ida Bagus Oka Widya Putra, Ida Bagus Manuaba   +3 more
openalex   +2 more sources