Results 21 to 30 of about 46,730 (243)
Phosphodiesterase 5 inhibitors: are they cardioprotective? [PDF]
Cardiovascular Research, 2009 A growing body of animal studies provides evidence for potential cardioprotective effects of inhibitors of the enzyme phosphodiesterase isoform 5. Infarct size reduction by administration of phosphodiesterase 5 inhibitors was described in various experimental models of ischaemia and reperfusion.
Thorsten, Reffelmann, Robert A, Kloner
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Portopulmonary hypertension practice patterns after liver transplantation
Liver Transplantation, EarlyView., 2022 Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose +3 more
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Therapeutic benefits of Phosphodiesterase type 5 inhibitors: A comprehensive review [PDF]
Archives of Pharmaceutical Sciences Ain Shams UniversityPhosphodiesterase type 5 (PDE5) inhibitors have been widely used to treat erectile dysfunction. This review aims to explore the favorable effects of PDE5 inhibitors in clinical applications beyond their conventional use.
Yasmin Nabil +3 more
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Evolution of Phosphodiesterase-5 Inhibitors
The World Journal of Men's Health, 2015 After the launch of sildenafil citrate (Viagra®), the last great invention of the 20th century, in 1998, oral phosphodiesterase (PDE)-5 inhibitors were established as first-line treatment for erectile dysfunction (ED), representing a paradigm shift in the diagnosis and treatment of ED [1].
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Applied Sciences, 2021 Alzheimer’s disease is a memory-related neurodegenerative condition leading to cognitive impairment. Cholinergic deficit, together with other underlying mechanisms, leads the to onset and progression of the disease.
Giovanni Ribaudo +2 more
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Antioxidant effects of phosphodiesterase-5 inhibitors: reply [PDF]
Cardiovascular Research, 2013 We thank Dr. Tanus-Santos for his interest in our study.1 The study by Muniz et al .2 found that erectile dysfunction patients with the lowest levels of endogenous nitric oxide (NO) have the best responses to the phosphodiesterase-5 (PDE5) inhibitor sildenafil.
Rui, Zhang, Zhi-Cheng, Jing
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Pharmacotherapy of erectile dysfunction: Current standards
Indian Journal of Urology, 2006 Pharmacotherapy is currently the therapeutic option of choice for erectile dysfunction. Comprising mainly intracavernosal injection therapy using alprostadil or alprostadil combined with phentolamine and/or papaverine and oral phosphodiesterase-5 ...
Kew-Kim Chew
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
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Antioxidant effects of phosphodiesterase-5 inhibitors [PDF]
Cardiovascular Research, 2013 This letter refers to ‘The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension’ by Y.-F. Fan et al ., Cardiovascular Research (2013) 99, 395–403. Fan et al .1 have shown convincing results indicating that the phosphodiesterase-5 (PDE5) inhibitor vardenafil reduces oxidative stress and this
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Arthritis Care &Research, EarlyView.Objective Mycophenolate mofetil (MMF) use in limited cutaneous systemic sclerosis (lcSSc) is relatively uncommon because of the lower fibrotic burden and the predominance of vascular complications. In vitro observations and clinical data from transplanted patients suggest a protective effect of MMF on endothelial function.
Enrico De Lorenzis +77 more
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