Results 61 to 70 of about 79,696 (205)

Signaling from blood vessels to CNS axons through nitric oxide [PDF]

, 2006
Brain function is usually perceived as being performed by neurons with the support of glial cells, the network of blood vessels situated nearby serving simply to provide nutrient and to dispose of metabolic waste.
Bartus, K, Dooldeniya, C, Garthwaite, G, Garthwaite, J, Goodwin, D, Kollb-Sielecka, M, Malcolm, D   +6 more
core   +1 more source

PHOSPHODIESTERASE-5 INHIBITORS USE IN PATIENTS WITH ERECTILE DYSFUNCTION AND CARDIOVASCULAR DISEASE IN CLINICAL PRACTICE

Рациональная фармакотерапия в кардиологии, 2016
About 150 million men worldwide and about 50% of men aged 40-88 y.o. in outpatient practice suffer from erectile dysfunction (ED). There is a linear relation between the age and ED rate. The main reason of ED in the majority of men (about 80% of patients)
M. N. Mamedov, G. G. Sharvadze, E. A. Poddubsky, A. K. Ausheva   +3 more
doaj   +1 more source

Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer

Nature Communications, 2020
Phosphodiesterase-5 (PDE5) inhibitors have been suggested to have an anti-tumor effect and block surgery-induced immunosuppression. Here, the authors show that postdiagnostic use of PDE5 inhibitors is associated with a decreased risk of colorectal ...
Wuqing Huang, Jan Sundquist, Kristina Sundquist, Jianguang Ji   +3 more
doaj   +1 more source

UPLC-MS/MS-Based Target Screening of 90 Phosphodiesterase Type 5 Inhibitors in 5 Dietary Supplements

Molecules
The aim of individuals consuming health supplements is to attain a robust state through nutritional regulation. However, some unscrupulous manufacturers, motivated by profit, fraudulently incorporate drugs or unauthorized components with therapeutic ...
Shaoming Jin, Yaonan Wang, Xiao Ning, Tongtong Liu, Ruiqiang Liang, Xinrong Pei, Jin Cao   +6 more
doaj   +1 more source

Benefits and risks of testosterone treatment for hypoactive sexual desire disorder in women: a critical review of studies published in the decades preceding and succeeding the advent of phosphodiesterase type 5 inhibitors

Clinics, 2014
With advancing age, there is an increase in the complaints of a lack of a libido in women and erectile dysfunction in men. The efficacy of phosphodiesterase type 5 inhibitors, together with their minimal side effects and ease of administration ...
Sandra Léa Bonfim Reis, Carmita H.N. Abdo   +1 more
doaj   +1 more source

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +3 more sources

Cardiovascular Effects of Phosphodiesterase Type 5 Inhibitors

The Journal of Sexual Medicine, 2009
ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) inhibitors are widely used as first-line therapy for erectile dysfunction (ED). Their efficacy and safety combined with an increasing understanding of cyclic guanosine monophosphate (cGMP)-regulated mechanisms have triggered a number of attempts to
Charalambos, Vlachopoulos, Nikolaos, Ioakeimidis, Konstantinos, Rokkas, Christodoulos, Stefanadis   +3 more
openaire   +2 more sources

Does the Daily Dose of Tadalafil for the Treatment of Erectile Dysfunction Increase Penile Sensation?

Journal of Urological Surgery, 2023
Objective:To investigate the effect of tadalafil, used for treating erectile dysfunction (ED) at a daily dose of 5 mg for 12 weeks, on penile sensation.Materials and Methods:Our study included 30 male patients who applied to our andrology outpatient ...
Selim Taş, Ekrem İslamoğlu, Ali Eren, Murat Savaş   +3 more
doaj   +1 more source

Data on the optimisation and validation of a liquid chromatography-high-resolution mass spectrometry (LC-HRMS) to establish the presence of phosphodiesterase 5 (PDE5) inhibitors in instant coffee premixes

Data in Brief, 2019
This paper presents the data on the optimisation and validation of a liquid chromatography-high-resolution mass spectrometry (LC-HRMS) to establish the presence of phosphodiesterase 5 (PDE5) inhibitors and their analogues as adulterants in instant coffee
Ahmad Yusri Mohd Yusop, Linda Xiao, Shanlin Fu   +2 more
doaj   +1 more source