Results 71 to 80 of about 46,730 (243)

Obesity and Erectile Dysfunction: From Bench to Clinical Implication

open access: yesThe World Journal of Men's Health, 2019
Obesity is a major public health issue worldwide and is frequently associated with erectile dysfunction (ED). Both condi-tions may share an internal pathologic environment, also known as common soil.
Ki Hak Moon   +2 more
doaj   +1 more source

Liposomal-delivery of phosphodiesterase 5 inhibitors augments UT-15C-stimulated ATP release from human erythrocytes

open access: yesBiochemistry and Biophysics Reports, 2017
The use of liposomes to affect targeted delivery of pharmaceutical agents to specific sites may result in the reduction of side effects and an increase in drug efficacy. Since liposomes are delivered intravascularly, erythrocytes, which constitute almost
Elizabeth A. Bowles   +3 more
doaj   +1 more source

Clinical Efficacy and Safety of Topical Roflumilast in Psoriasis: An Updated Systematic Review and Meta‐Analysis of Randomized Controlled Trials

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Traditional first‐line topical treatments for plaque psoriasis, particularly corticosteroids and vitamin D analogs, frequently have only limited efficacy for long‐term use, and present difficulties with safety and adherence. Objectives In this systematic review and meta‐analysis of randomized controlled trials (RCTs), we assessed ...
Aimal A. Khattak   +11 more
wiley   +1 more source

Avanafil for erectile dysfunction in elderly and younger adults: differential pharmacology and clinical utility

open access: yesTherapeutics and Clinical Risk Management, 2014
Eric G Katz,1 Ronny BW Tan,2 Daniel Rittenberg,1 Wayne J Hellstrom3 1Tulane University School of Medicine, New Orleans, LA, USA; 2Department of Urology, Tan Tock Seng Hospital, Singapore; 3Section of Andrology, Department of Urology, Tulane University ...
Katz EG   +3 more
doaj  

Phosphodiesterase Type-5 Inhibitor and Oxidative Stress

open access: yesInternational Journal of Immunopathology and Pharmacology, 2008
Erectile dysfunction (ED) is a common medical condition that affects the sexual life of millions of men worldwide. Numerous physical and psychological factors are involved in normal erectile function, including neurological, vascular, hormonal and cavernous functions.
SPERANZA, Lorenza   +7 more
openaire   +3 more sources

Protective Effects of Riociguat Against Contrast‐Induced Nephropathy: An Experimental and Machine Learning‐Based Study in Rats

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov   +10 more
wiley   +1 more source

A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2013
The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men.
Cristiane Franco Codevilla   +2 more
doaj  

Management options for the treatment of benign prostatic hyperplasia with or without erectile dysfunction: a focus on tadalafil and patient considerations

open access: yesInternational Journal of General Medicine, 2014
Bader Alsaikhan, Khalid Alrabeeah, Serge CarrierMcGill University Health Centre, Montreal, Quebec, QC, CanadaAbstract: Lower urinary tract symptoms (LUTS) and erectile dysfunction increase with age.
Alsaikhan B, Alrabeeah K, Carrier S
doaj  

Peyronie's Disease: Evolving Surgical Management and the Role of Phosphodiesterase 5 Inhibitors

open access: yesThe Scientific World Journal, 2009
Peyronie's disease (PD) is a fibrotic disorder of the tunica albuginea of the penis. It is characterized by different degrees of penile curvature and sexual dysfunction.
Tariq F. Al-Shaiji, Gerald B. Brock
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág   +5 more
wiley   +1 more source

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