Results 11 to 20 of about 2,974,682 (398)

Effectiveness of Phosphodiesterase-5 Inhibitor Therapy for Portopulmonary Hypertension

Canadian Respiratory Journal, 2015
BACKGROUND: Portopulmonary hypertension is associated with significant morbidity and mortality. Phosphodiesterase-5 inhibitor therapy is efficacious in other causes of WHO group I pulmonary arterial hypertension.
Jolene H Fisher, Sindhu R Johnson, Cathy Chau, Amie T Kron, John T Granton   +4 more
doaj   +2 more sources

The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson's disease. [PDF]

PLoS One, 2017
Background/Aims Since the degeneration of the nigrostriatal dopaminergic pathway in Parkinson’s disease (PD) is associated with the inflammation process and decreased levels of cyclic nucleotides, inhibition of up-regulated cyclic nucleotide ...
Schwenkgrub J, Zaremba M, Joniec-Maciejak I, Cudna A, Mirowska-Guzel D, Kurkowska-Jastrzębska I.   +5 more
europepmc   +2 more sources

CGMP Phosphodiesterase Inhibitor [PDF]

Definitions, 2020
openaire   +2 more sources

Trial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis.

New England Journal of Medicine, 2022
BACKGROUND Phosphodiesterase 4 (PDE4) inhibition is associated with antiinflammatory and antifibrotic effects that may be beneficial in patients with idiopathic pulmonary fibrosis.
L. Richeldi, A. Azuma, V. Cottin, C. Hesslinger, S. Stowasser, C. Valenzuela, M. Wijsenbeek, D. Zoz, F. Voß, T. Maher   +9 more
semanticscholar   +1 more source

Difamilast, a selective phosphodiesterase 4 inhibitor, ointment in paediatric patients with atopic dermatitis: a phase III randomized double‐blind, vehicle‐controlled trial

British Journal of Dermatology, 2021
In atopic dermatitis (AD), phosphodiesterase 4 (PDE4) inhibition reduces proinflammatory mediators and cytokines. Difamilast is a new selective PDE4 inhibitor.
H. Saeki, N. Baba, K. Ito, D. Yokota, H. Tsubouchi   +4 more
semanticscholar   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

Hemorrhagic Cholecystitis in an Elderly Patient Taking Aspirin and Cilostazol

Case Reports in Gastroenterology, 2008
Hemorrhage is a rare complication of acute cholecystitis. Patients who develop this complication often are receiving anticoagulation therapy or have a pathologic coagulopathy.
David S. Morris, John R. Porterfield, Mark D. Sawyer   +2 more
doaj   +1 more source

The low KM-phosphodiesterase inhibitor denbufylline enhances neuronal excitability in guinea pig hippocampus in vitro [PDF]

, 1990
The actions of the phosphodiesterase inhibitor denbufylline on the excitability of hippocampal neurons were investigated by means of extracellular and intracellular recordings.
Alzheimer, Christian, Ameri, A., Sutor, Bernd, Ten Bruggencate, Gerrit   +3 more
core   +1 more source

Roflumilast: Review of Phosphodiesterase-4 Inhibitor as Asthma Therapy

Jurnal Ilmiah Kesehatan, 2021
Asthma is a heterogeneous disease characterized by chronic inflammation of the airways induced reversible obstruction resulting in mortality and morbidity. Roflumilast is a second-generation selective inhibitor of phosphodiesterase-4  targeting PDE type
Rafina Syfridiana, Fauna Herawati
doaj   +1 more source

Is phosphodiesterase type 5 inhibitor use associated with condom breakage? [PDF]

, 2009
This is an open access article - Copyright © 2009 by the BMJ Publishing Group Ltd. All rights reserved.We tested the hypothesis that phosphodiesterase type 5 inhibitor (PDE5i) use would be associated with increased likelihood of condom breakage using an
Crosby, RA, Graham, CA, Sanders, SA, Yarber, WL   +3 more
core   +1 more source