Results 11 to 20 of about 101,846 (359)

Apremilast

Turkderm Turkish Archives of Dermatology and Venereology, 2022
Apremilast is an orally used small-molecule inhibitor of phosphodiesterase-4. It has been approved for the treatment of adult patients with psoriatic arthritis and moderate to severe plaque psoriasis.
Nihal Kundakçı
doaj   +1 more source

Effect of a three-piece inflatable penile prosthesis combined with a phosphodiesterase-5 inhibitor on erectile dysfunction

Journal of International Medical Research, 2021
Objective To investigate the therapeutic effect of implanting a three-piece inflatable penile prosthesis (IPP) combined with the phosphodiesterase-5 inhibitor sildenafil in severe erectile dysfunction (ED) patients.
Jian Wang, Peng Wu, Qiang Liu, Liangliang Ben, Geng Chen, Zhijuan Han, Hui Peng   +6 more
doaj   +1 more source

Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA. [PDF]

PLoS ONE, 2010
The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated hemorrhagic transformation.
Mitsunori Ishiguro, Keisuke Mishiro, Yasuyuki Fujiwara, Huayue Chen, Hiroshi Izuta, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Masahiko Satoh, Toru Iwama, Hideaki Hara   +10 more
doaj   +1 more source

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. [PDF]

PLoS ONE, 2011
BACKGROUND: Phosphodiesterase 7 plays a major role in down-regulation of protein kinase A activity by hydrolyzing cAMP in many cell types. This cyclic nucleotide plays a key role in signal transduction in a wide variety of cellular responses.
Jose A Morales-Garcia, Miriam Redondo, Sandra Alonso-Gil, Carmen Gil, Concepción Perez, Ana Martinez, Angel Santos, Ana Perez-Castillo   +7 more
doaj   +1 more source

Effects and mechanisms of action of sildenafil citrate in human chorionic arteries

Reproductive Biology and Endocrinology, 2009
Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg, O'Toole Daniel, Maharaj Chrisen H, Carney John, Jarman James, Higgins Brendan D, Morrison John J, Laffey John G   +7 more
doaj   +1 more source

Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. [PDF]

J Am Heart Assoc, 2016
BackgroundSystemic vasodilation using α‐receptor blockade has been shown to decrease the incidence of postoperative cardiac arrest following stage 1 palliation (S1P), primarily when utilizing the modified Blalock‐Taussig shunt.
Mills KI, Kaza AK, Walsh BK, Bond HC, Ford M, Wypij D, Thiagarajan RR, Almodovar MC, Quinonez LG, Baird CW, Emani SE, Pigula FA, DiNardo JA, Kheir JN.   +13 more
europepmc   +2 more sources

Hemorrhagic Cholecystitis in an Elderly Patient Taking Aspirin and Cilostazol

Case Reports in Gastroenterology, 2008
Hemorrhage is a rare complication of acute cholecystitis. Patients who develop this complication often are receiving anticoagulation therapy or have a pathologic coagulopathy.
David S. Morris, John R. Porterfield, Mark D. Sawyer   +2 more
doaj   +1 more source

Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus

Nature Communications, 2023
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament ...
Anna M. Sigmund, Markus Winkler, Sophia Engelmayer, Daniela Kugelmann, Desalegn T. Egu, Letyfee S. Steinert, Michael Fuchs, Matthias Hiermair, Mariya Y. Radeva, Franziska C. Bayerbach, Elisabeth Butz, Stefan Kotschi, Christoph Hudemann, Michael Hertl, Sunil Yeruva, Enno Schmidt, Amir S. Yazdi, Kamran Ghoreschi, Franziska Vielmuth, Jens Waschke   +19 more
doaj   +1 more source

Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma

Allergology International, 2009
Background: Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling. Objective: The aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 and 1 dual inhibitor, on chronic airway inflammation and
Toshiyuki Kita, Masaki Fujimura, Shigeharu Myou, Kazuyoshi Watanabe, Yuko Waseda, Shinji Nakao   +5 more
doaj   +1 more source

Research of cGMP- and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of platelets aggregation activity in patients with heart failure and metabolic disturbances

Бюллетень сибирской медицины, 2012
Data of the study of cGMP- and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of the platelet aggregation activity in 25 patients with DM2 and heart failure are presented.
O. N. Ogurkova, T. Ye. Suslova, A. V. Sitoshevsky, O. A. Koshelskaya   +3 more
doaj   +1 more source