Results 111 to 120 of about 53,329 (292)

Structural insight into selective phosphodiesterase 4B inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics simulations

, 2017
Structural insight into selective phosphodiesterase 4B inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics ...
Vidushi Sharma (2632084), Sharad Wakode (2632087)   +1 more
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]

, 1994
Meyer, M. F., Schulz-Knappe, P., Forssmann, W. G., Stief, Christian Georg, Taher, A., Jonas, Udo, Truss, Michael C.   +6 more
core   +1 more source

LC-ESI-MS/MS analysis of phosphodiesterase-5 inhibitors and their analogues in foods and dietary

, 2015
Chemical structures of phosphodiesterase-5 (PDE-5) inhibitors and thier ...
Ji hye Jeong (815475), Ji Hyun Lee, Hyung Joo Kim, Hyoung Joon Park, In Sun Hwang, Kyoung Moon Han, (815479)   +1 more
core   +1 more source

Polyglycolic Acid Polymer Versus Porcine Small Intestine Submucosa Graft After Plaque Incision in Peyronie's Disease: A Comparative Study

Andrology, EarlyView.
ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost, Leonardo Seligra Lopes, Pedro Caetano Edler Zandoná, Jovânio Fernandes da Rosa, Pedro Fernandes Lessa, Felipe Placco Araujo Glina, Nívio Pascoal Teixeira, Sidney Glina   +7 more
wiley   +1 more source

Type 4 Phosphodiesterase Inhibitors Have Clinical and In Vitro Anti-inflammatory Effects in Atopic Dermatitis

, 1996
Increased cyclic AMP-phosphodiesterase activity in peripheral blood leukocytes is associated with the immune and inflammatory hyperreactivity that characterizes atopic dermatitis.
Chan, Sai C., Tofte, Susan J., Weiner, Ethan S., Henderson, William R., Kirby, Deborah S., Hanifin, Jon M., Cheng, John B.   +6 more
core   +1 more source

SIEDY Diagnostic Accuracy in Assessing Erectile Dysfunction in Young Men Living With HIV

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction (ED) is a multidimensional condition commonly affecting men living with HIV. The structured interview of erectile dysfunction (SIEDY) is the only validated tool assessing organic, relational, and psychological factors contributing to ED, while dynamic penile color Doppler ultrasound (dPCDU) is a reliable method ...
Giorgio Tiecco, Federico Cesanelli, Cosimo Colangelo, Marco Di Gregorio, Andrea Delbarba, Paolo Facondo, Matteo Riva, Carlo Cappelli, Emanuele Focà, Francesco Castelli, Eugenia Quiros‐Roldan   +10 more
wiley   +1 more source

Use of Phosphodiesterase Inhibitors in the Postoperative Period of Skin Flaps: A Systematic Review. [PDF]

Plast Reconstr Surg Glob Open, 2023
Daronch OT, Marcante RFR, Neto AAP, Viterbo F.   +3 more
europepmc   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Eudistomin derivatives, novel phosphodiesterase inhibitors: synthesis and relative activity

, 1988
The preparations of novel phosphodiesterase inhibitors, 8-acetoxy-5-iodo-6-methoxypy rido[3,4-b]indole, 5,7-dibromo-6-hydroxypyrido[3,4-b]indole, 5,7-dichloro-6-hydroxypyrido[3,4-b]-indole and 8-acetoxy-5-bromo-6-methoxypyrido[3,4-b]indole, are described
Tohru Hino, Mikio Taniguchi, Jun'ichi Kobayashi, Yasushi Ohizumi   +3 more
core   +1 more source