Results 91 to 100 of about 53,329 (292)

Sexual function in hypertensive patients receiving treatment

Vascular Health and Risk Management, 2006
Thorsten Reffelmann, Robert A KlonerUniversity of Southern California, The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, Los Angeles, CA, USAAbstract: In many forms of erectile dysfunction (ED ...
Thorsten Reffelmann, Robert A Kloner
doaj  

molecular docking and molecular dynamics of phytochemicals as potential inhibitors of phosphodiesterase 4B

Journal of Chemical Research
Phosphodiesterase 4B is an important enzyme belonging to the phosphodiesterase family, playing a role in regulating the levels of cyclic AMP in cells. Phosphodiesterase 4B degrades cyclic AMP, a crucial signaling molecule involved in numerous biological ...
Cao Hoang Minh Chau, Ngu Thi Tra Giang, Nguyen Thi Thuy Tram, Le Thi My Chau, Nguyen Xuan Ha, Phan Thi Thuy   +5 more
doaj   +1 more source

Clinical Efficacy and Safety of Topical Roflumilast in Psoriasis: An Updated Systematic Review and Meta‐Analysis of Randomized Controlled Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Traditional first‐line topical treatments for plaque psoriasis, particularly corticosteroids and vitamin D analogs, frequently have only limited efficacy for long‐term use, and present difficulties with safety and adherence. Objectives In this systematic review and meta‐analysis of randomized controlled trials (RCTs), we assessed ...
Aimal A. Khattak, Ahmed Javed, Ummi Aiman Rahman, Rumaisa Riaz, Zeeshan Imtiaz, Hassan A. Mirza, Farman U. Khan, Muhid Khattak, Fatima Javid, Abdul Moiz Khan, Adeline L. Roy, Bibek Shrestha   +11 more
wiley   +1 more source

Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries

, 2004
Inhibitors of phosphodiesterases 3 and 4, the main cyclic AMP (cAMP) degrading enzymes in arteries, may have therapeutic potential in cerebrovascular disorders. We analysed the effects of such phosphodiesterases in guinea pig cerebral arteries with organ
Edvinsson, Lars, Birk, Steffen, Kruuse, Christina Rostrup, Olesen, Jes   +3 more
core   +1 more source

PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects [PDF]

, 2015
The important regulator of cardiac function, cAMP, is hydrolyzed by different cyclic nucleotide phosphodiesterases (PDEs), whose expression and activity are not uniform throughout the heart. Of these enzymes, PDE2 shapes β1 adrenoceptor-dependent cardiac
Handschin, Christoph, Fernández-Belda, Francisco, Pérez-Schindler, Joaquín, Fuente, Teodomiro, Hernandez-Cascales, Jesús, Soler, Fernando   +5 more
core   +1 more source

Protective Effects of Riociguat Against Contrast‐Induced Nephropathy: An Experimental and Machine Learning‐Based Study in Rats

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov, Kenan Toprak, Sibel Turedi, İsmail Koyuncu, Zulkif Tanrıverdi, Necip Fazıl Dedeoglu, Halil Fedai, Asuman Bicer, İbrahim Halil Altıparmak, Recep Demirbag, Gencay Sarıısık   +10 more
wiley   +1 more source

Advances in the treatment of Raynaud’s phenomenon

Vascular Health and Risk Management, 2010
Terri L LevienDrug Information Pharmacist and Clinical Associate Professor, College of Pharmacy, Washington State University Spokane, WA, USAAbstract: Raynaud’s phenomenon is a common condition characterized by vasospasm of the digital arteries
Terri L Levien
doaj  

Ciprofloxacin-Induced Antibacterial Activity Is Attenuated by Phosphodiesterase Inhibitors

Current Therapeutic Research, 2015
Background: Ciprofloxacin is a commonly used antibiotic for urinary tract infection that interacts with bacterial topoisomerases leading to oxidative radicals generation and bacterial cell death.
Majed M. Masadeh, PhD, Karem H. Alzoubi, PhD, Omar F. Khabour, Sayer I. Al-Azzam, Msc   +3 more
doaj   +1 more source

Determination of the presence of phosphodiesterase inhibitors in municipal wastewater

, 2014
This diploma thesis is focused on the determination of phosphodiesterase 5 selective inhibitors in communal waste waters. In this study phosphodiesterase inhibitors levels in municipal waste waters from sewage treatment plants with different numbers of ...
Smutná, Michaela
core  

Biomarkers of response to therapy in Ankylosing Spondylitis [PDF]

, 2013
Ankylosing Spondylitis (AS) is a chronic inflammatory disorder of the spine which leads to progressive spinal fusion and deformity. With improvements in MRI, this condition is now being recognized earlier.
Pathan, Ejaz Mohammed Ishaq
core   +1 more source