Results 91 to 100 of about 623,776 (234)

Phosphodiesterase Inhibitors in Object Recognition and Object Location Memory Tests

, 2018
Phosphodiesterase (PDE) inhibitors prevent hydrolyzation of the second messengers cyclic adenosine monophosphate and cyclic guanosine monophosphate; they are considered promising cognitive enhancers.
Argyrousi, Elentina K., Pim R.A. Heckman, Elentina K. Argyrousi, Jos Prickaerts, Heckman, Pim R.A.; id_orcid, Prickaerts, Jos   +5 more
core   +2 more sources

Donkwa Enriched With Goron‐Tula (Azanza garckeana) Modulates Sexual Behavior and Activity of Enzymes Linked With Erectile Dysfunction in High‐Fat Diets/ Streptozotocin‐Induced (STZ/HFD) Diabetic Rats

Food Chemistry International, EarlyView.
(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi, O. S. Ijarotimi, A. A. Badejo   +2 more
wiley   +1 more source

Sexual function in hypertensive patients receiving treatment

Vascular Health and Risk Management, 2006
Thorsten Reffelmann, Robert A KlonerUniversity of Southern California, The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, Los Angeles, CA, USAAbstract: In many forms of erectile dysfunction (ED ...
Thorsten Reffelmann, Robert A Kloner
doaj  

Phenanthrenes from as Novel Phosphodiesterase-5 Inhibitors

Natural Product Communications, 2017
Phosphodiesterase 5 (PDE5) inhibitors can be used for the treatment of erectile dysfunction and pulmonary hypertension. In order to search for new leads of PDE5 inhibitors, we investigated the chemical constituents of the tubers of Eulophia macrobulbon ...
Prapapan Temkitthawon, Kanokwan Changwichit, Nantaka Khorana, Jarupa Viyoch, Khanit Suwanborirux, Kornkanok Ingkaninan   +5 more
doaj   +1 more source

The Next Generation of Phosphodiesterase Inhibitors:  Structural Clues to Ligand and Substrate Selectivity of Phosphodiesterases

, 2016
The Next Generation of Phosphodiesterase Inhibitors:  Structural Clues to Ligand and Substrate Selectivity of ...
Richard A. Hughes (1441735), David T. Manallack (1616794), Philip E. Thompson (1374795)   +2 more
core   +1 more source

The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review. [PDF]

, 2017
Agents that augment cerebral blood flow (CBF) could be potential treatments for vascular cognitive impairment. Phosphodiesterase-5 inhibitors are vasodilating drugs established in the treatment of erectile dysfunction (ED) and pulmonary hypertension.
Moynihan, B, Mathilde MH Pauls, Kruuse, C, Christina Kruuse, Isaacs, Jeremy D, Hainsworth, AH, Jeremy B Madigan, Jeremy D Isaacs, Madigan, Jeremy B, Hainsworth, Atticus H, Thomas R Barrick, Atticus H Hainsworth, Madigan, JB, Barry Moynihan, Barrick, TR, Barrick, Thomas R, Pauls, MM, Pauls, Mathilde Mh, Isaacs, JD, Moynihan, Barry, Kruuse, Christina   +20 more
core   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Ciprofloxacin-Induced Antibacterial Activity Is Attenuated by Phosphodiesterase Inhibitors

Current Therapeutic Research, 2015
Background: Ciprofloxacin is a commonly used antibiotic for urinary tract infection that interacts with bacterial topoisomerases leading to oxidative radicals generation and bacterial cell death.
Majed M. Masadeh, PhD, Karem H. Alzoubi, PhD, Omar F. Khabour, Sayer I. Al-Azzam, Msc   +3 more
doaj   +1 more source

Maternal and perinatal outcomes of pregnant women with echocardiographically high probability of pulmonary arterial hypertension

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study aimed to describe maternal and perinatal outcomes among pregnant women with echocardiographically high probability of pulmonary arterial hypertension (PAH) managed at a quaternary center and to compare outcomes between women with and without cardiac complications (CC).
Laura Belmont‐Rojo, Rosa Hernandez‐Cruz, Ana Jimena Lopez‐Diaz, Diana Yazmin Copado‐Mendoza, Tirso Rubalcava‐Rubalcava, Mario Isaac Lumbreras‐Marquez, Maria Antonia Pijuan‐Domenech   +6 more
wiley   +1 more source

Advances in the treatment of Raynaud’s phenomenon

Vascular Health and Risk Management, 2010
Terri L LevienDrug Information Pharmacist and Clinical Associate Professor, College of Pharmacy, Washington State University Spokane, WA, USAAbstract: Raynaud’s phenomenon is a common condition characterized by vasospasm of the digital arteries
Terri L Levien
doaj