Results 81 to 90 of about 623,776 (234)

Building families—Implementing balanced sexual and reproductive health

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning and family building.
Peter Y. Liu, Edgar Mocanu, Linda Giudice, Marcos Horton, Meletios P. Nigdelis, Antti Perheentupa, Andrea Sansone, Giovanni Corona, Luca Gianaroli, Dimitrios G. Goulis   +9 more
wiley   +2 more sources

Effect of phosphodiesterase inhibitors on platelet function

Biochemistry and Biophysics Reports
Phosphodiesterase enzymes (PDEs) play a pivotal role in regulating platelet activity by modulating intracellular levels of cAMP and cGMP. Modulation of PDE-2, -3 and -5 activity by suitable inhibitors has been found to reduce platelet activity, and thus ...
Ravi Hochuli, Valerie Dicenta, Zoi Laspa, Manuel Sigle, Tobias Harm, Tatsiana Castor, Anne-Katrin Rohlfing, Meinrad Paul Gawaz   +7 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Phosphodiesterase 5 inhibitors: current status and potential applications

, 2002
Phosphodiesterase enzymes convert cyclic GMP and cyclic AMP to the corresponding nucleotide monophosphates. Phosphodiesterase 5 (PDE5) inhibition is now a widely accepted and efficacious therapeutic option for the treatment of erectile dysfunction in men,
Rotella, David, David P. Rotella
core   +1 more source

Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors [PDF]

, 2012
Trypanosoma cruzi phosphodiesterase C (TcrPDEC) is a potential new drug target for the treatment of Chagas disease but has not been well studied. This study reports the enzymatic properties of various kinetoplastid PDECs and the crystal structures of the
Chen, Gong, Robinson, Howard, Wang, Huanchen, Seebeck, Thomas, Martinelli, Sibylla, Wan, Yiqian, Ke, Hengming, Wang, H., Wan, Y., Ke, H., Martinelli, S., Kunz, Stefan, Kunz, S., Chen, G., Robinson, H., Seebeck, T.   +15 more
core   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Phosphodiesterase 5 inhibitors in male sexual dysfunction.

, 2003
PURPOSE OF REVIEW Phosphodiesterase 5 inhibitors are preferred by most men for the oral treatment of erectile dysfunction. In many guidelines, this therapy is recommended as first-line therapy because of convenience, high efficacy, and low rates of side ...
Kuthe A
core   +1 more source

Electronic Nose‐Based Methanol Feedback Precision Control Strategy for High‐Yield Alkaline Phosphatase Fermentation by Hansenula polymorpha

Food Bioengineering, EarlyView.
Establishment of Closed‐Loop Methanol Feedback Precision Control System for Alkaline Phosphatase by Hansenula polymorpha. The electronic nose screened model for methanol detection as the core technical logic of online gas quantification. Methanol feedback control strategy for greatly elevating alkaline phosphatase production.
Jian‐Guang Liang, Shao‐Jie Wang, Jia‐Jia Wang, Muhammad Safwan Siddique, Zishu Zhang, Ciying Xiao, Ze‐Jian Wang   +6 more
wiley   +1 more source

molecular docking and molecular dynamics of phytochemicals as potential inhibitors of phosphodiesterase 4B

Journal of Chemical Research
Phosphodiesterase 4B is an important enzyme belonging to the phosphodiesterase family, playing a role in regulating the levels of cyclic AMP in cells. Phosphodiesterase 4B degrades cyclic AMP, a crucial signaling molecule involved in numerous biological ...
Cao Hoang Minh Chau, Ngu Thi Tra Giang, Nguyen Thi Thuy Tram, Le Thi My Chau, Nguyen Xuan Ha, Phan Thi Thuy   +5 more
doaj   +1 more source

PHARMACOLOGY OF PHOSPHODIESTERASE‐5 INHIBITORS

International Journal of Clinical Practice, 2002
SUMMARYThe clinical properties (efficacy and safety profile) of a medicine are related not only to its mode of action, but also to its selectivity for its target (usually a receptor or enzyme) and are also influenced by its pharmacokinetic properties (absorption, distribution, metabolism and elimination).
J D, Corbin, S H, Francis
openaire   +2 more sources