Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules. [PDF]
Front Pharmacol, 2022 Bondarev AD +6 more
europepmc +1 more source
Ixekizumab Type I Allergy in a Patient With Psoriasis
JEADV Clinical Practice, EarlyView.ABSTRACT A 52‐year‐old Caucasian woman was referred for an allergy workup of suspected type I allergy to the interleukin (IL)‐17A inhibitor ixekizumab. Five months after ixekizumab initiation, she suddenly developed intense pruritus and three small wheals at the injection site approximately 30 min after injection, lasting up to 3 days.
Carina Borst +2 more
wiley +1 more source
Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment of Erectile Dysfunction. [PDF]
Gels, 2023 Mohamed SA +6 more
europepmc +1 more source
Genital Psoriasis: Shining Light on This Hidden Disease
JEADV Clinical Practice, EarlyView.Psoriasis occurring on skin of the genital and perigenital regions has specific diagnostic and treatment requirements due to the sensitivity and private nature of these areas. A multidisciplinary group of experts in the management of genital psoriasis, the Genital Psoriasis Wellness Consortium, convened to discuss the impact of genital psoriasis on ...
Jennifer Cather +19 more
wiley +1 more source
Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension: Focus on Phosphodiesterase Inhibitors. [PDF]
Pharmaceuticals (Basel), 2022 Ovchinnikov A +3 more
europepmc +1 more source
Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors. [PDF]
, 1982 We have measured the levels of 3',5'-guanosine monophosphate (cyclic GMP) in isolated retinas from toad to investigate their correlation to the opening and closing of the light-dependent permeability of photoreceptors. When Ca2+-induced changes in cyclic
Fain, GL, Woodruff, ML
core
Efficacy of Apremilast in Refractory Genital Psoriasis: A Retrospective Case Series
JEADV Clinical Practice, EarlyView.ABSTRACT Background Genital pustular psoriasis is a rare and often underdiagnosed condition that can severely affect physical comfort, quality of life and psychological well‐being. It can be particularly challenging to manage, often requiring systemic therapies due to its potential unresponsiveness to conventional topical treatment.
Jonathan Krygier +2 more
wiley +1 more source
Journal of Pharmacological Sciences, 2013 Phosphodiesterase 4 (PDE4) inhibitors have been developed for the treatment of pulmonary inflammatory diseases, but their clinical use was dose-limited by mainly gastric adverse effects.
Osamu Suzuki +12 more
doaj
Canadian Respiratory Journal, 2008 BACKGROUND: Pulmonary arterial hypertension (PAH) remains a progressive disease despite improvement when using one of three medication classes: prostanoids, endothelin receptor antagonists or phosphodiesterase-5 inhibitors.
Nancy R Porhownik +2 more
doaj +1 more source
New Prospective Phosphodiesterase Inhibitors: Phosphorylated Oxazole Derivatives in Treatment of Hypertension. [PDF]
Adv Pharm Bull, 2023 Nizhenkovska IV +5 more
europepmc +1 more source