Results 151 to 160 of about 87,967 (330)
Phosphodiesterase inhibitors and the cardiovascular system
Continuing Education in Anaesthesia Critical Care & Pain, 2007 Phosphodiesterase is a ubiquitous enzyme that catalyses the hydrolysis of phosphodiester bonds. It is responsible for the hydrolysis of cyclic 3,5 adenosine monophosphate (cAMP) and 3,5 cyclic guanosine monophosphate (cGMP). Both cAMP, and to a lesser extent cGMP, have an important role in the regulation of inotropic mechanisms in the human myocardium.
openaire +2 more sources
PROTEOMICS – Clinical Applications, EarlyView.ABSTRACT Background Capillary blood collection has a number of advantages over venous collection, especially in the context of increasing decentralized clinical trials and field‐based testing. No studies are available comparing venous versus capillary blood collection for proteomics measurement.
Mary Ni Lochlainn +4 more
wiley +1 more source
Bioinformatics‐Based Comparative Analysis of the Human Retina Proteome
PROTEOMICS – Clinical Applications, EarlyView.ABSTRACT Introduction The human retina relies on a complex network of proteins, many of which exhibit intrinsic disorder and liquid‐liquid phase separation (LLPS), enabling dynamic interactions for retinal function. Disruptions in these properties, along with missense mutations, have been linked to retinal diseases.
Colin K. Kim +8 more
wiley +1 more source
Drug Design, Development and Therapy, 2016 Marilita M Moschos, Eirini Nitoda 1st Department of Ophthalmology, Medical School, National & Kapodistrian University of Athens, Athens, Greece Aim: The aim of this review was to summarize the ocular action of the most common phosphodiesterase (PDE)
Moschos MM, Nitoda E
doaj
The effect of K-252a, a potent microbial inhibitor of protein kinase, on activated cyclic nucleotide phosphodiesterase [PDF]
, 1988 Y Matsuda +4 more
openalex +1 more source
United European Gastroenterology Journal, EarlyView.ABSTRACT Background Cholangiocarcinoma presents a global health challenge due to its increasing incidence and poor prognosis, primarily resulting from delayed diagnosis. There is an urgent need for a reliable biomarker to enhance early detection. Materials and Methods Patients with cholangiocarcinoma were enrolled into three cohorts: a discovery set (n
Lichieh Julie Chu +6 more
wiley +1 more source
Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation. [PDF]
Pharmaceuticals (Basel), 2022 Wójcik-Pszczoła K +8 more
europepmc +1 more source
The Journal of Dermatology, EarlyView.ABSTRACT This open‐label, single‐arm, multicenter clinical study evaluated the treatment satisfaction, efficacy, and safety of 0.5% delgocitinib ointment twice daily for 12 weeks, applied to face/neck lesions caused by ≥ 3 months use of topical steroids or tacrolimus ointment in patients with atopic dermatitis (AD).
Masatoshi Abe +5 more
wiley +1 more source
The Prevalence and Severity of Pain in Patients With Systemic Sclerosis
The Journal of Dermatology, EarlyView.ABSTRACT We investigated pain prevalence and severity in systemic sclerosis (SSc) and patient–physician perceptions. This was an internet‐based survey that compared perceptions of pain type, location, severity, associated factors between patients with SSc and physicians, and pain treatment prescription patterns in Japan in March 2023.
Sei‐ichiro Motegi +6 more
wiley +1 more source