Results 11 to 20 of about 2,803,213 (206)
Effect of phosphodiesterase inhibitors in the bladder. [PDF]
Asian J Urol, 2015 Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients.
Chughtai B, Ali A, Dunphy C, Kaplan SA.
europepmc +2 more sources
Chemotherapeutic efficacy of phosphodiesterase inhibitors in chagasic cardiomyopathy. [PDF]
JACC Basic Transl Sci, 2016 Molecular mechanisms of Trypanosoma cruzi (Tc)-induced Chagasic cardiomyopathy (CCM) are not well understood. The NO-cGMP-PKG1α pathway maintains cardiac homeostasis and inotropy and may be disturbed due to phosphodiesterase (PDE5)-mediated cGMP ...
Wen JJ, Wan X, Thacker J, Garg NJ.
europepmc +2 more sources
The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review
Frontiers in Pharmacology, 2022 Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer’s disease (AD) because it maintains the homeostasis of 3ʹ,5ʹ-cyclic adenosine monophosphate (cAMP) and 3ʹ,
Nazir Ahmad +5 more
doaj +1 more source
Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis. [PDF]
EBioMedicine, 2016 Ahidjo BA, Bishai WR.
europepmc +2 more sources
Phosphodiesterase Inhibitors: Present and Future
Barcelona Respiratory Network Reviews, 2023 Phosphodiesterase (PDE) inhibitors act on specific phosphodiesterase enzymes (fundamentally 3, 4 and 5), which are characterized by their expression in different organs.
José L. Izquierdo-Alonso
doaj +1 more source
Annual Review of Pharmacology and Toxicology, 2022 Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family ...
Arun Samidurai +3 more
semanticscholar +1 more source
Applied Sciences, 2021 Alzheimer’s disease is a memory-related neurodegenerative condition leading to cognitive impairment. Cholinergic deficit, together with other underlying mechanisms, leads the to onset and progression of the disease.
Giovanni Ribaudo +2 more
doaj +1 more source
Andrology, 2022 Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first‐line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data suggest that diabetic men may be ...
A. Cayetano-Alcaraz +4 more
semanticscholar +1 more source
Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review
Dermatologic Therapy, 2020 Due to immune‐mediated nature, medicines with immunomodulatory and anti‐inflammatory effects can used to treat many dermatologic diseases. Phosphodiesterase and prostaglandins are involved in many inflammatory pathways that cause cutaneous disorders ...
Nafise Yazdanian +2 more
semanticscholar +1 more source
Pulmonary Circulation, 2020 Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited.
Robert P. Frantz +6 more
doaj +1 more source