Results 81 to 90 of about 2,870,340 (221)

New Prospective Phosphodiesterase Inhibitors: Phosphorylated Oxazole Derivatives in Treatment of Hypertension. [PDF]

Adv Pharm Bull, 2023
Nizhenkovska IV, Matskevych KV, Golovchenko OI, Golovchenko OV, Kustovska AD, Van M.   +5 more
europepmc   +1 more source

EFFECTS OF CYCLIC AMP‐ AND CYCLIC GMP‐PHOSPHODIESTERASE INHIBITORS ON IMMUNOLOGICAL RELEASE OF HISTAMINE AND ON LUNG CONTRACTION [PDF]

, 1981
Nelly Frossard, Yves Landry, G. Pauli, M. Ruckstuhl   +3 more
openalex   +1 more source

Inhibition of Colon Cancer Cell Growth by Phosphodiesterase Inhibitors Is Independent of cGMP Signaling. [PDF]

J Pharmacol Exp Ther, 2022
Hou Y, Wren A, Mylarapu N, Browning K, Islam BN, Wang R, Vega KJ, Browning DD.   +7 more
europepmc   +1 more source

Effects of phosphodiesterase inhibitors on normal and chemically‐skinned isolated airway smooth muscle [PDF]

, 1987
Susan E. Bryson, Ian W. Rodger
openalex   +1 more source

Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions

Pharmacology Research & Perspectives
The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre‐contracted with 5‐HT (100 μM).
Iris Lim, Taishi Masutani, Hikaru Hashitani, Russ Chess‐Williams, Donna Sellers   +4 more
doaj   +1 more source

Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis. [PDF]

J Pharmacol Exp Ther, 2022
Świerczek A, Pomierny B, Wyska E, Jusko WJ.   +3 more
europepmc   +1 more source

Impacts of anti-inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation. [PDF]

Pharmacol Res Perspect, 2021
Zheng XF, Chen DD, Zhu XL, Le Grange JM, Zhou LQ, Zhang JN.   +5 more
europepmc   +1 more source

Phosphodiesterase inhibitors and the cardiovascular system

Continuing Education in Anaesthesia Critical Care & Pain, 2007
Phosphodiesterase is a ubiquitous enzyme that catalyses the hydrolysis of phosphodiester bonds. It is responsible for the hydrolysis of cyclic 3,5 adenosine monophosphate (cAMP) and 3,5 cyclic guanosine monophosphate (cGMP). Both cAMP, and to a lesser extent cGMP, have an important role in the regulation of inotropic mechanisms in the human myocardium.
openaire   +2 more sources

In silico exploration of antinociceptive activity of 1,4-benzodiazepines: Molecular docking on α1 A-adrenoceptor, and phosphodiesterase 4

Regulatory Mechanisms in Biosystems
Recently, scientists have established that several benzodiazepines were found to enhance the activation of a cAMP response element pathway by α1A-adrenergic receptors, but this effect was attributed to off-target inhibition of phosphodiesterases 4.
A. S. Akisheva, V. B. Larionov, M. Y. Golovenko, O. A. Makarenko, I. P. Valivodz, I. Y. Borysiuk, Y. O. Molodan   +6 more
doaj   +1 more source

Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values [PDF]

, 1988
Gerard J. Murphy, Miles D. Houslay
openalex   +1 more source