Results 171 to 180 of about 45,588 (281)

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

The Therapeutic Efficacy of Drugs Targeting the NO‐sGC‐cGMP Pathway in Treatment of Patients With Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Chronic thromboembolic pulmonary hypertension (CTEPH) is a distinct and potentially curable form of pulmonary hypertension; however, a substantial proportion of patients remain inoperable or experience persistent or recurrent disease. Pharmacological therapies targeting the nitric oxide–soluble guanylate cyclase–cyclic guanosine monophosphate (
Abdullah A. Alqarni, Rawan H. Aljedani, Abdulelah M. Aldhahir, Ahmed H. Alasimi, Abdulkareem A. AlGarni, Jaber S. Alqahtani, Saeed Mardy Alghamdi, Rayan A. Siraj, Aminah Mengash, Hassan Alwafi   +9 more
wiley   +1 more source

The Role of Piezo Ion Channels in Pulmonary Hypertension

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Pulmonary hypertension (PH) is a chronic and devastating disease that currently lacks effective therapies, often ultimately requiring lung transplantation. Pulmonary vascular cells are subjected to various mechanical forces, which contribute to cardiovascular remodeling in PH.
Kewei Chen, Lingchen Li, Yajie Huang, Lixia Ye, Yu Wang, Ziming Zhang, Chengcheng Hang, Qiqi Li, Qianyun Cao, Lizhong Du   +9 more
wiley   +1 more source

The Clinical and Economic Burden of Pulmonary Arterial Hypertension in Israel, 2014–2022: A Retrospective Analysis of Healthcare Costs and Utilization

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a rare, progressive disease with high morbidity and mortality. Real‐world data from Israel are scarce. This study aimed to estimate the incidence, describe treatment patterns, and quantify healthcare utilization and costs associated with PAH in Israel.
Yaki Saciuk, Carole Mamane, Tal Patalon, Laurie Lévy‐Bachelot, Moshe Hoshen, Sarah Sharman Moser, Inbal Shafran, Mohamed Safwat, Yochai Adir, Ran Numa, Eliad Ben‐dayan, Sivan Gazit, Michael J. Segel   +12 more
wiley   +1 more source

Phosphodiesterase Type 5 Inhibitor Sildenafil Decreases the Proinflammatory Chemokine CXCL10 in Human Cardiomyocytes and in Subjects with Diabetic Cardiomyopathy. [PDF]

Inflammation, 2016
Di Luigi L, Corinaldesi C, Colletti M, Scolletta S, Antinozzi C, Vannelli GB, Giannetta E, Gianfrilli D, Isidori AM, Migliaccio S, Poerio N, Fraziano M, Lenzi A, Crescioli C.   +13 more
europepmc   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

P6.11 PHOSPHODIESTERASE TYPE-5 INHIBITOR USE IN TYPE 2 DIABETES IS ASSOCIATED WITH A REDUCTION IN ALL CAUSE MORTALITY

Artery Research, 2014
S. Anderson, D. Hutchings, C. Kwok, A. Trafford, A. Heald   +4 more
doaj   +1 more source

Dual phosphodiesterase type 5 inhibitor therapy for refractory pulmonary arterial hypertension: a pilot study. [PDF]

BMC Pulm Med, 2015
Kimura M, Tamura Y, Takei M, Yamamoto T, Ono T, Fujita J, Kataoka M, Kuwana M, Satoh T, Fukuda K.   +9 more
europepmc   +1 more source

675: Phosphodiesterase Type 5 Inhibitor Therapy Corrects “Nitric Oxide” Imbalance in Sickle Cell Anemia-Associated Priapism [PDF]

, 2007
Hunter C. Champion, Biljana Musicki, Lewis L. Hsu, Trinity J. Bivalacqua, Arthur L. Burnett, Mark T. Gladwin   +5 more
core   +1 more source

Revisiting Controversial Areas in the Management of Premature Ejaculation

Trends in Urology &Men's Health, Volume 17, Issue 4, August 2026.
ABSTRACT The cause of premature ejaculation (PE) is often multifactorial in nature, and effective management of PE is complex and should involve multimodal approaches. This narrative review examines the ongoing controversies surrounding key areas in the diagnosis and treatment of PE with an emphasis on future research directions to align clinical care ...
Dong Sup Lee, Min Gu Park, Sun Tae Ahn, Ho Seok Chung, Hwancheol Son, Hyun Jun Park, Eric Chung   +6 more
wiley   +1 more source