Results 191 to 200 of about 45,588 (281)

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

open access: yesAdvanced Science, Volume 13, Issue 39, 13 July 2026.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao   +10 more
wiley   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK Pathways

open access: yesArthritis &Rheumatology, Volume 78, Issue 7, Page 1535-1553, July 2026.
Objective Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla   +13 more
wiley   +1 more source

1202: Long-Term Phosphodiesterase Type 5 Inhibitor Therapy Reduces Priapic Activity in Transgenic Sickle Cell Mice [PDF]

open access: yes, 2006
Hunter C. Champion   +3 more
core   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

open access: yesChirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz   +1 more
wiley   +1 more source

Sodium Butyrate Attenuates Sevoflurane‐Induced Impaired Myelination and Neurobehavioral Deficits in Neonatal Mice via the H3K9ac/BDNF/TrkB Pathway

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Repeated exposure to sevoflurane in neonatal mice leads to impaired myelin development and neurobehavioral dysfunction, a process closely associated with reduced butyrate levels in vivo. Sodium butyrate supplementation effectively ameliorates these sevoflurane‐induced abnormalities by downregulating HDAC3 and HDAC8 expression, enhancing H3K9ac levels ...
Chang Liu   +6 more
wiley   +1 more source

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

open access: yesFood Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Cilostazol for Probable Swallow Syncope Associated With Sick Sinus Syndrome in a Nonagenarian Receiving Home‐Based Care: A Case Report

open access: yesJournal of General and Family Medicine, Volume 27, Issue 4, July 2026.
ABSTRACT Background Swallow syncope is a rare reflex syncope, typically treated with pacemaker implantation. Pharmacological alternatives may be considered when pacemaker implantation is not feasible or not concordant with goals of care. Case Presentation We report a nonagenarian woman with dementia, very severe aortic stenosis, heart failure, and sick
Hiromitsu Yamashita   +2 more
wiley   +1 more source

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