Effects of cyclic adenosine 3,5-monophosphate on photoreceptor disc shedding and retinomotor movement. Inhibition of rod shedding and stimulation of cone elongation. [PDF]
, 1982 As a test of the hypothesis that cyclic nucleotides play a role in the regulation of retinomotor movements and disc shedding in the photoreceptor-pigment epithelial complex, we have used an in vitro eyecup preparation that sustains both disc shedding and
Besharse, J, BURNSIDE, Beth, Dunis, D
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The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference! [PDF]
, 2015 Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the most serious human diseases, including Chagas disease (Trypanosoma ...
De Koning, Harry P. +2 more
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Women taking the “blue pill” (sildenafil citrate): such a big deal?
Drug Design, Development and Therapy, 2014 Giuseppe Lo Monte, Angela Graziano, Isabella Piva, Roberto Marci Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, Italy Abstract: For years, phosphodiesterase type 5 inhibitors have been used for the ...
Lo Monte G, Graziano A, Piva I, Marci R
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Urology Annals, 2015 Introduction: The aim of this study was to evaluate the combination of intralesional verapamil injection (IVI) therapy with and tadalafil in men affected by Peyronie′s disease (PD).
Lucio Dell′Atti
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EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis [PDF]
, 2004 BACKGROUND: Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro.
Beier, Norbert +2 more
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Asian Journal of Andrology, 2016 The effectiveness of phosphodiesterase type 5 inhibitors (PDE5-Is) for erectile dysfunction (ED) varies considerably among trials, but available studies investigating the factors that affect the effectiveness are few and findings are not consistent.
Jin-Qiu Yuan +5 more
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Neural networks and support vector machines based bio-activity classification [PDF]
, 2006 Classification of various compounds into their respective biological activity classes is important in drug discovery applications from an early phase virtual compound filtering and screening point of view. In this work two types of neural networks, multi
Salim, Naomie, Zeb Shah, Jehan
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Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory [PDF]
, 2016 Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial ...
Abel, Ted +13 more
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Oral Phosphodiesterase Type 5 Inhibitors: Nonerectogenic Beneficial Uses
The Journal of Sexual Medicine, 2008 ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) hydrolyses cyclic guanylate monophosphate (cGMP) specifically to 5′ GMP. PDE5 inhibitors were a breakthrough medication that addressed a previously unfulfilled medical need.
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Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]
, 1998 Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F. +1 more
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