Results 61 to 70 of about 27,465 (289)

Effect of cAMP signaling on expression of glucocorticoid receptor, Bim and Bad in glucocorticoid-sensitive and resistant leukemic and multiple myeloma cells

Frontiers in Pharmacology, 2015
Stimulation of cAMP signaling induces apoptosis in glucocorticoid-sensitive and resistant CEM leukemic and MM.1 multiple myeloma cell lines, and this effect is enhanced by dexamethasone in both glucocorticoid-sensitive cell types and in glucocorticoid ...
Hongli eDong, Michael E. Carlton, Adam eLerner, Paul Mark Epstein   +3 more
doaj   +1 more source

Characterization and Modification of Light-Sensitive Phosphodiesterases from Choanoflagellates

Biomolecules, 2022
Enzyme rhodopsins, including cyclase opsins (Cyclops) and rhodopsin phosphodiesterases (RhoPDEs), were recently discovered in fungi, algae and protists. In contrast to the well-developed light-gated guanylyl/adenylyl cyclases as optogenetic tools, ideal ...
Yuehui Tian, Shang Yang, Georg Nagel, Shiqiang Gao   +3 more
doaj   +1 more source

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5 [PDF]

, 2002
Background The cyclic AMP specific phosphodiesterase, PDE4D5 interacts with the β-propeller protein RACK1 to form a signaling scaffold complex in cells.
Bolger, G.B., Houslay, M., McCahill, A., Steele, M.R., Warwicker, J., Yarwood, S.   +5 more
core   +3 more sources

Mammalian Glycerophosphodiester Phosphodiesterases [PDF]

Bioscience, Biotechnology, and Biochemistry, 2007
Bacterial glycerophosphodiester phosphodiesterases (GP-PDEs), GlpQ and UgpQ, are well-characterized periplasmic and cytosolic proteins that play critical roles in the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol, which are utilized as major sources of carbon and phosphate.
openaire   +2 more sources

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Molecular, Enzymatic, and Cellular Characterization of Soluble Adenylyl Cyclase From Aquatic Animals. [PDF]

, 2018
The enzyme soluble adenylyl cyclase (sAC) is the most recently identified source of the messenger molecule cyclic adenosine monophosphate. sAC is evolutionarily conserved from cyanobacteria to human, is directly stimulated by [Formula: see text] ions ...
Acin-Perez, Barott, Barott, Barott, Beltrán, Berthelot, Bitterman, Bordeaux, Braun, Braun, Braun, Buck, Camacho Londoño, Chaloupka, Chen, Chen, Cooper, De Rasmo, Di Benedetto, Elliott, Farrell, Geng, Goldberg, Gordeladze, Hess, Hrdlickova, Jaiswal, Kobayashi, Leparc, Levin, Litvin, Magro, Neer, Neer, Nomura, Nomura, Ramos-Espiritu, Roa, Roa, Roa, Salem, Salomon, Schwencke, Steegborn, Steegborn, Stessin, Structural Genomics Consortium, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Wilson, Yeo, Zaccolo, Zippin, Zippin, Zippin, Zippin   +58 more
core   +2 more sources

Phosphodiesterases and preeclampsia

Medical Hypotheses, 2017
Antagonizing vasodilation has been considered one of the potential mechanisms underlying the pathophysiology of preeclampsia. Phosphodiesterases hydrolyze cGMP, interfering with the action of nitric oxide on vascular smooth muscle, thus causing vasoconstriction.
Anne Brandolt, Larré, Aline, Parisotto, Bruna Fagundes, Rockenbach, Débora Montenegro, Pasin, Cláudia, Capellari, Daniele Cristovão, Escouto, Bartira Ercília, Pinheiro da Costa, Carlos Eduardo, Poli-de-Figueiredo   +7 more
openaire   +2 more sources

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?

Frontiers in Physiology, 2018
Spontaneous firing of sinoatrial (SA) node cells (SANCs) is regulated by cyclic adenosine monophosphate (cAMP)-mediated, protein kinase A (PKA)-dependent (cAMP/PKA) local subsarcolemmal Ca2+ releases (LCRs) from ryanodine receptors (RyR).
Tatiana M. Vinogradova, Evgeny Kobrinsky, Edward G. Lakatta   +2 more
doaj   +1 more source

Kefir protects the liver against high fructose corn syrup induced phosphodiesterase hyperactivity

Türk Biyokimya Dergisi, 2022
Phosphodiesterases (PDEs) mediate several physiological activities, and alterations in PDE expressions might cause conflicts between functional and clinical effects.
Pektaş Mehmet Bilgehan, Aslan Esra, Güzel Hilal, Korkmaz Ömer Adil, Çeleğen Kübra, Pektaş Ayhan, Bostanci Aykut, Sadi Gökhan   +7 more
doaj   +1 more source