Results 81 to 90 of about 27,465 (289)

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Using a Robust and Sensitive GFP-Based cGMP Sensor for Real-Time Imaging in Intact Caenorhabditis elegans. [PDF]

, 2019
cGMP plays a role in sensory signaling and plasticity by regulating ion channels, phosphodiesterases, and kinases. Studies that primarily used genetic and biochemical tools suggest that cGMP is spatiotemporally regulated in multiple sensory modalities ...
Ali, Nebat, Andersen, Kristine, Barsi-Rhyne, Benjamin, Brueggemann, Chantal, Costa, Wagner Steuer, Ferkey, Denise M, Futey, Mary, Gottschalk, Alexander, Hamilton, O Scott, Hill, Tyler, Krzyzanowski, Michelle C, L'Etoile, Noelle, Li, Joy, Mitchell, Jordan, Nagpal, Jatin, Schneider, Martin W, Sengupta, Piali, Shankar, Raakhee, Tran, Alan, VanHoven, Miri, Varshney, Aruna, Woldemariam, Sarah, Yu, Yanxun V   +22 more
core  

Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice

Advanced Science, EarlyView.
A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi, Shuang He, Chengyi Li, Hung Chan, Zhenfeng Liu, Bin Yang, Qing Li   +6 more
wiley   +1 more source

mSphere of Influence: Compartmentalized cAMP signals in American trypanosomes

mSphere
Noelia Lander works on cell signaling in American trypanosomes and studies the role of cyclic adenosine monophosphate (cAMP) microdomains in environmental sensing and differentiation. In this mSphere of Influence, Dr.
Noelia Lander
doaj   +1 more source

Downstream Targets of Cyclic Nucleotides in Plants

Frontiers in Plant Science, 2018
Efficient integration of various external and internal signals is required to maintain adaptive cellular function. Numerous distinct signal transduction systems have evolved to allow cells to receive these inputs, to translate their codes and ...
Brygida Świeżawska, Maria Duszyn, Krzysztof Jaworski, Adriana Szmidt-Jaworska   +3 more
doaj   +1 more source

PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex [PDF]

, 2017
The levels of cAMP are regulated by phosphodiesterase enzymes (PDEs), which are targets for the treatment of inflammatory disorders. We have previously shown that PDE8 regulates T cell motility.
Baillie, George S., Basole, Chaitali P., Brocke, Stefan, Clark, Robert, Epstein, Paul M, Lamothe, Katie, Nguyen, Rebecca K., Vang, Amanda   +7 more
core   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Two phosphodiesterases from Ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases

Frontiers in Microbiology, 2010
The dependence of Protein Kinase A (PKA) activity on cAMP levels is an important facet of the dimorphic switch between budding and filamentous growth as well as for pathogenicity in some fungi.
Charu eAgarwal, David J Schultz, Michael H Perlin   +2 more
doaj   +1 more source

The protozoan parasite Toxoplasma gondii encodes a gamut of phosphodiesterases during its lytic cycle in human cells

Computational and Structural Biotechnology Journal, 2020
Cyclic nucleotide signaling is pivotal to the asexual reproduction of Toxoplasma gondii, however little do we know about the phosphodiesterase enzymes in this widespread obligate intracellular parasite.
Kim Chi Vo, Özlem Günay-Esiyok, Nicolas Liem, Nishith Gupta   +3 more
doaj   +1 more source