Results 111 to 120 of about 28,180 (258)

Glucose Metabolic Reprogramming in Colorectal Cancer: From Mechanisms to Targeted Therapy Approaches

Cancer Medicine, Volume 14, Issue 17, September 2025.
ABSTRACT Background Colorectal cancer (CRC) is one of the most common malignant tumors, and its morbidity ranks third among all cancers, with a trend toward younger patients. Metabolic reprogramming, a unique metabolic mode in tumor cells, is closely related to the occurrence and development of CRC. Numerous studies have confirmed that many genetic and
Runkai Zhou, Fazhi Wang, Jiazhe Wen, Xuefeng Zhou, Yugang Wen   +4 more
wiley   +1 more source

ATP8B1 Deficiency Causes Phosphodiesterase 4‐Mediated Glucagon Resistance and Impaired Gluconeogenesis in Mouse and Human Liver

Liver International, Volume 45, Issue 9, September 2025.
ABSTRACT Background and Aims Deficiency of the phospholipid transporter ATP8B1 causes infantile‐onset progressive familial intrahepatic cholestasis type I (PFIC1). Pre‐transplant PFIC1 patients often present with mild dyslipidaemia. This raises the possibility that PFIC1 patients, besides cholestasis, may also experience defects in glucose and lipid ...
Jung‐Chin Chang, Wietse In het Panhuis, Shu‐Hao Hsu, Suzanne Duijst, Kam S. Ho‐Mok, Jolie F. van der Heiden, Zhixiong Ying, Joris I. Erdmann, Georg F. Vogel, Norman Junge, Björn Hartleben, Pim J. Koelink, Sebastian G. van Dijk, Weng Chuan Peng, Arthur J. Verhoeven, Ronald P. J. Oude Elferink, Huey‐Ling Chen, Stan F. J. van de Graaf, Coen C. Paulusma   +18 more
wiley   +1 more source

Ablation of Hepatocyte Derived‐FGL1 Does Not Aggravate Metabolic Dysfunction‐Associated Steatotic Liver Disease

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Wild‐type and mice with specific ablation of Fgl1 in hepatocyte exhibit a comparable phenotype during experimental steatosis, hepatocellular carcinoma, and acute liver injury. ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) begins with simple steatosis, which can progress to hepatocellular carcinoma (HCC).
Jean Personnaz, Lisa Cannizzo, Céline Marie Pauline Martin, Aurore Desquesnes, Manon Sotin, Joanna DaSilva, Prunelle Perrier, Hervé Guillou, Léon Kautz   +8 more
wiley   +1 more source

Macrophage phenotype in response to ECM bioscaffolds [PDF]

, 2017
Macrophage presence and phenotype are critical determinants of the healing response following injury. Downregulation of the pro-inflammatory macrophage phenotype has been associated with the therapeutic use of bioscaffolds composed of extracellular ...
Badylak, Stephen F, Bartolacci, Joseph G., Brown, Bryan N., Cramer, Madeline C., Dziki, Jenna L., Huleihel, Luai, LoPresti, Samuel T., Rausch, Theresa, Scarritt, Michelle E., Swinehart, Ilea T., Vorobyov, Tatiana, White, Lisa J.   +11 more
core   +2 more sources

Alteration of the interconversion of pyruvate and malate in the plastid or cytosol of ripening tomato fruit invokes diverse consequences on sugar but similar effects on cellular organic Acid, metabolism, and transitory starch accumulation

, 2013
The aim of this work was to investigate the effect of decreased cytosolic phosphoenolpyruvate carboxykinase (PEPCK) and plastidic NADP-dependent malic enzyme (NADP-ME) on tomato (Solanum lycopersicum) ripening.
Angelovici, R., Fernie, A., Galili, G., Osorio, S., Szecowka, M., Tzin, V., Ufaz, S., Vallarino, J.   +7 more
core   +1 more source

Actinomyces spp. gene expression in root caries lesions [PDF]

, 2016
Background: studies of the distribution of Actinomyces spp. on carious and non-carious root surfaces have not been able to confirm the association of these bacteria with root caries, although they were extensively implicated as a prime suspect in root ...
Damé-Teixeira, N, Devine, DA, Do, T, Maltz, M, Parolo, CCF, Tugnait, A   +5 more
core   +2 more sources

Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver [PDF]

, 1967
F J Ballard, RW Hanson
openalex   +1 more source

The activities of fructose 1,6-diphosphatase, phosphofructokinase and phosphoenolpyruvate carboxykinase in white muscle and red muscle [PDF]

, 1967
LH Opie, E. A. Newsholme
openalex   +1 more source

Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle [PDF]

, 2000
The glyoxylate cycle is regarded as essential for postgerminative growth and seedling establishment in oilseed plants. We have identified two allelic Arabidopsis mutants, icl-1 and icl-2, which lack the glyoxylate cycle because of the absence of the key ...
Bryce, J.H., Eastmond, P.J., Germain, V., Graham, I.A., Lange, P.R., Smith, S.M.   +5 more
core   +2 more sources

Structure and Mechanism of Phosphoenolpyruvate Carboxykinase [PDF]

Journal of Biological Chemistry, 1997
Louis T. J. Delbaere, Hughes Goldie, Leslie W. Tari, Allan Matte   +3 more
openaire   +3 more sources