Results 111 to 120 of about 41,691 (279)

The Ω-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.

Biochemistry, 2012
Phosphoenolpyruvate carboxykinase (PEPCK) is an essential metabolic enzyme operating in the gluconeogenesis and glyceroneogenesis pathways. Recent studies have demonstrated that the enzyme contains a mobile active site lid domain that undergoes a ...
T. Johnson, T. Holyoak
semanticscholar   +1 more source

Boundaries of photosynthesis: adaptations of carbon fixation in extreme environments

FEBS Open Bio, Volume 15, Issue 7, Page 1028-1040, July 2025.
Photosynthesis faces challenges from environmental extremes of temperature, pH, and salinity, limiting gas diffusion, modifying membrane fluidity, and destabilizing photochemical and biochemical reactions. Photosynthetic organisms have evolved unique adaptations overcoming these stresses and maintaining their photosynthetic activity.
Pere Aguiló‐Nicolau, Concepción Iñiguez, Sebastià Capó‐Bauçà, Jeroni Galmés   +3 more
wiley   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, Volume 37, Issue 23, June 12, 2025.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Heat Stress Response in Ruditapes Decussatus: Transcriptional Regulation of Key Pathways and Novel SNPs in Antioxidant Genes

Ecology and Evolution, Volume 15, Issue 6, June 2025.
Climate change is known to affect all levels of biology, setting at risk ecological balance. Among other organisms' groups, aquatic inhabitants, and particularly bivalves, are expected to be influenced to a greater extent owing to their inability to move to more mild temperatures.
Dimitrios K. Papadopoulos, Basile Michaelidis, Ioannis A. Giantsis   +2 more
wiley   +1 more source

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

iMeta, Volume 4, Issue 3, June 2025.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen, Wenxin Qu, Mengdi Song, Tianyu Zhang, Chang Liu, Xiaofeng Shi, Xinxin Xu, Jingjing Jiang, Liguo Ding, Fangyu Mo, Zheying Mao, Mingzhu Huang, Ziye Xu, Jiaye Chen, Enhui Shen, Jian Ruan, Jiong Liu, Michael P. Timko, Yu Chen, Longjiang Fan, Shufa Zheng, Yongcheng Wang   +21 more
wiley   +1 more source

Role and Mechanisms of the mTOR Signalling Pathway in the Synthesis of Milk Components

Modern Agriculture, Volume 3, Issue 1, June 2025.
The regulatory network system of mTOR regulates lactose, milk fat, and milk protein. Milk is urgently needed for the strong development of the dairy industry to meet the growing demand and ensure that the nutritional needs of the world's population are met.
RongNuo Li, YiNing Zheng, HuiJun Geng, Lu Deng   +3 more
wiley   +1 more source

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, Volume 292, Issue 12, Page 2973-2991, June 2025.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice[S]

Journal of Lipid Research, 2010
The aim of this study was to investigate the role of the cytosolic form of phosphoenolpyruvate carboxykinase (Pck1) in the development of insulin resistance.
Carrie A. Millward, D. Desantis, Chang-Wen Hsieh, Jason D. Heaney, Sorana G. Pisano, Yael Olswang, L. Reshef, M. Beidelschies, M. Puchowicz, C. Croniger   +9 more
semanticscholar   +1 more source

Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells[S]

Journal of Lipid Research, 2011
Previously, we have shown that Pck1 expression in mammary gland adipocytes and white adipose tissue maintains triglyceride stores through glyceroneogenesis, and these lipids were used for synthesis of milk triglycerides during lactation.
Chang-Wen Hsieh, Charles Huang, Ilya Bederman, Jianqi Yang, Michelle Beidelschies, Maria Hatzoglou, Michelle Puchowicz, Colleen M. Croniger   +7 more
doaj