Results 111 to 120 of about 43,737 (252)

Proximal Tubule‐Specific Genetic Deficiency of PPARα Worsens Systemic Lipid and Glucose Metabolism During Fasting

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Proximal tubule‐specific PPARα knockout mouse (PPARαΔKPT) showed decreased lipid and glucose metabolism in the kidney during fasting. Metabolism in the other organs was increased, presumably as a means of compensating for the impaired kidney metabolism.
Daiki Aomura, Takayuki Nimura, Kosuke Yamaka, Yosuke Yamada, Makoto Harada, Takero Nakajima, Takefumi Kimura, Koji Hashimoto, Hiroyuki Kanno, Motoko Yanagita, Frank J. Gonzalez, Naoki Tanaka, Yuji Kamijo   +12 more
wiley   +1 more source

Actinomyces spp. gene expression in root caries lesions [PDF]

, 2016
Background: studies of the distribution of Actinomyces spp. on carious and non-carious root surfaces have not been able to confirm the association of these bacteria with root caries, although they were extensively implicated as a prime suspect in root ...
Damé-Teixeira, N, Devine, DA, Do, T, Maltz, M, Parolo, CCF, Tugnait, A   +5 more
core   +2 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, Volume 16, Issue 1, Page 199-221, January 2026.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

Sinapine Modulates Glycogen and Lipid Synthesis via IRS1–PI3K–AKT–GSK3β–GS Pathway in Insulin‐Resistant Models

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study combined network pharmacology, molecular docking, and in vitro (HepG2) and in vivo (T2DM mice) experiments to investigate sinapine's effect on insulin resistance. Sinapine was found to modulate the IRS1–PI3K–AKT–GSK3β–GS pathway. In vitro, sinapine improved glucose uptake, enhanced glycogen synthesis, and reduced lipogenesis and ROS. In vivo,
Tiancheng Xing, Yiling Bai, Weijie Wu, Ziqi Zhao, Hanyu Kong, Qianyi Zhang, Shuoqi Li, Yan Liu, Xiaohui Guo, Zengli Wang   +9 more
wiley   +1 more source

Comparative ubiquitinome analysis reveals the roles of protein ubiquitination in the heat stress response from Metarhizium robertsii

Applied and Environmental Microbiology
Protein ubiquitination plays a vital role in the stress response of diverse filamentous fungi. However, few reports are available on fungal insect pathogens, including Metarhizium.
Jueping Song, Ali Raza, Hanyuan Chen, Guangshuo Li, Bo Huang, Zhangxun Wang   +5 more
doaj   +1 more source

Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice[S]

Journal of Lipid Research, 2010
The aim of this study was to investigate the role of the cytosolic form of phosphoenolpyruvate carboxykinase (Pck1) in the development of insulin resistance.
Carrie A. Millward, D. Desantis, Chang-Wen Hsieh, Jason D. Heaney, Sorana G. Pisano, Yael Olswang, L. Reshef, M. Beidelschies, M. Puchowicz, C. Croniger   +9 more
semanticscholar   +1 more source

Ancestral light and chloroplast regulation form the foundations for C4 gene expression. [PDF]

, 2016
C4 photosynthesis acts as a carbon concentrating mechanism that leads to large increases in photosynthetic efficiency. The C4 pathway is found in more than 60 plant lineages1 but the molecular enablers of this evolution are poorly understood.
Boursnell, Chris, Burgess, Steven J, Granero-Moya, Ignasi, Grangé-Guermente, Mathieu J, Hibberd, Julian M, Terry, Matthew J   +5 more
core   +2 more sources

Comprehensive Analysis of Malate Accumulation in Peaches in Response to Cold Stress Based on Transcriptomics

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study explored malate‐accumulation mechanisms in “Hujingmilu” peaches under different storage conditions. Low temperature (LT) delayed firmness decline and maintained higher malate. Transcriptomics showed malate biosynthetic genes weakly correlate with malate levels, while proton pump and transporter genes were up‐regulated under LT.
Hongfang Cai, Shuai Han, Xu Wang, Jiqing Shi, Zewen Xiong, Zheng Zhang, Zhuyi Gao   +6 more
wiley   +1 more source

Ischaemic and metabolic treatment of hepatic tumours [PDF]

, 1988
For treatment of malignancies, physical and metabolic differences between tumour cells and host cells have guided the development of new approaches.
Ahrén, B, Bengmark, S
core   +3 more sources