Results 1 to 10 of about 10,168 (226)

Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. [PDF]

J Biol Chem, 2007
Transgenic mice, containing a chimeric gene in which the cDNA for phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C) (EC 4.1.1.32) was linked to the α-skeletal actin gene promoter, express PEPCK-C in skeletal muscle (1-3 units/g).
Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW.   +14 more
europepmc   +4 more sources

Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. [PDF]

Proceedings of the National Academy of Sciences, 1983
The gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) [GTP:oxaloacetate carboxy-lyase (transphosphorylating), EC 4.1.1.32] from the rat was isolated from a recombinant library containing the rat genome in phage lambda Charon 4A. The isolated clone, lambda PCK1, contains the complete gene for phosphoenolpyruvate carboxykinase and approximately ...
David Samols, Heidi P. Short, Jay M. Short, Anthony Wynshaw-Boris, Herman Meisner, Alan Bruzel, Heeja Yoo-Warren, John Monahan, Richard W. Hanson   +8 more
semanticscholar   +5 more sources

Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP).

Journal of Biological Chemistry, 1976
The hypoglycemic agent 3-mercaptopicolinic acid inhibits gluconeogenesis from lactate by isolated, perfused livers from fasted rats and guinea pigs. A 3-mercaptopicolinate concentration of 50 muM caused a sharp decrease in glucose synthesis, with virtually complete inhibition at 100 muM.
Mireille Jomain-Baum, Vern L. Schramm, Richard W. Hanson   +2 more
semanticscholar   +4 more sources

In Vitro Analysis of Promoter Elements Regulating Transcription of the Phosphoenolpyruvate Carboxykinase (GTP) Gene [PDF]

Molecular and Cellular Biology, 1990
A cell-free system for the study of transcription from the promoter of the phosphoenolpyruvate carboxykinase (GTP) gene by using nuclear extracts from rat tissues was developed. The level of basal transcription from the phosphoenolpyruvate carboxykinase (PEPCK) promoter between -490 and +73 was highest when extracts from liver nuclei, rather than ...
Dwight J. Klemm, Jinsong Liu, William J. Roesler, Edwards A. Park, Richard W. Hanson   +4 more
semanticscholar   +6 more sources

Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin [PDF]

Biochemical Journal, 1976
1. The regulation of the synthesis of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) in epididymal adipose tissue, liver and kidney in vivo was studied immunochemically. 2. Phosphoenolpyruvate carboxykinase (GTP) synthesis in adipose tissue is increased by starvation, diabetes and noradrenaline, and decreased by re-feeding and insulin.
O Meyuhas, Lea Reshef, J M Gunn, Richard W. Hanson, F J Ballard   +4 more
semanticscholar   +5 more sources

SREBP-1c and Sp1 Interact to Regulate Transcription of the Gene for Phosphoenolpyruvate Carboxykinase (GTP) in the Liver [PDF]

Journal of Biological Chemistry, 2004
The sterol regulatory element-binding protein-1c (SREBP-1c), as well as SREBP-1a and SREBP-2, inhibit transcription of the gene encoding the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C). There are two SREBP regulatory elements (SREs) in the PEPCK-C gene promoter (-322 to -313 and -590 to -581).
Shwu Yuan Wu, Richard W. Hanson, Cheng Ming Chiang, David Samols, Kaushik Chakravarty   +4 more
semanticscholar   +6 more sources

Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. [PDF]

J Biol Chem, 2009
The SIRT1 activators isonicotinamide (IsoNAM), resveratrol, fisetin, and butein repressed transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C).
Yang J, Kong X, Martins-Santos ME, Aleman G, Chaco E, Liu GE, Wu SY, Samols D, Hakimi P, Chiang CM, Hanson RW.   +10 more
europepmc   +2 more sources

Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tissues [PDF]

Frontiers in Physiology
Epizootic shell disease (ESD) is characterized by shell erosion, pitting, and melanization in the American lobster (Homarus americanus) and is associated with a polymicrobial infection.
Minseo Kim, Dianjun Cao, Vincent Cavaleri, Kyudong Han, Kyudong Han, Kyudong Han, Seyoung Mun, Seyoung Mun, Seyoung Mun, Soo Jin Jeon   +9 more
doaj   +2 more sources

The Role of the CCAAT/Enhancer-Binding Protein in the Transcriptional Regulation of the Gene for Phosphoenolpyruvate Carboxykinase (GTP) [PDF]

Molecular and Cellular Biology, 1990
Previous studies have identified a region in the promoter of the gene for phosphoenolpyruvate carboxykinase (GTP) (PEPCK) (positions -460 to +73) containing the regulatory elements which respond to cyclic AMP, glucocorticoids, and insulin and confer the tissue- and developmental stage-specific properties to the gene.
Jinsong Liu, Edwards A. Park, William J. Roesler, Austin L. Gurney, Alan D. Friedman, Jack D. Thatcher, Dwight J. Klemm, Richard W. Hanson, Jon Shuman   +8 more
openaire   +4 more sources

Phylogenetic Study of the Evolution of PEP-Carboxykinase [PDF]

Evolutionary Bioinformatics, 2007
Phosphoenolpyruvate carboxykinase (PCK) is the key enzyme to initiate the gluconeogenic pathway in vertebrates, yeast, plants and most bacteria. Nucleotide specificity divided all PCKs into two groups.
Sanjukta Aich, Louis T.J. Delbaere
doaj   +4 more sources