Results 1 to 10 of about 2,330 (168)

Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse [PDF]

Journal of Biological Chemistry, 2007
Gemma Casadesus, David R Hagen, David L Wilson   +2 more
exaly   +4 more sources

Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tissues [PDF]

Frontiers in Physiology
Epizootic shell disease (ESD) is characterized by shell erosion, pitting, and melanization in the American lobster (Homarus americanus) and is associated with a polymicrobial infection.
Minseo Kim, Dianjun Cao, Vincent Cavaleri, Kyudong Han, Kyudong Han, Kyudong Han, Seyoung Mun, Seyoung Mun, Seyoung Mun, Soo Jin Jeon   +9 more
doaj   +2 more sources

Mn2+-sensitive and -insensitive forms of phosphoenolpyruvate carboxykinase (GTP).

Journal of Biological Chemistry, 1981
Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) from rat liver cytosol is activated by micromolar concentrations of Mn2+ under conditions where GTP is present as the MgGTP complex and free Mg2+ is present in excess. The purified, homogeneous enzyme rapidly loses the ability to be activated by Mn2+ upon storage, incubation with oxidized ...
R I, Brinkworth, R W, Hanson, F A, Fullin, V L, Schramm   +3 more
openaire   +3 more sources

Processing of phosphoenolpyruvate carboxykinase (GTP) RNA in vivo. [PDF]

Proceedings of the National Academy of Sciences, 1985
Nuclear RNA precursors to the mRNA for rat cytosolic phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) and nuclear RNA species smaller in size than the mature enzyme mRNA have been identified by using hybridization probes specific for introns and exons from the gene.
M, Hatzoglou, C E, Sekeris, R W, Hanson
openaire   +4 more sources

Roles of Asp75, Asp78, and Glu83 of GTP-dependent Phosphoenolpyruvate Carboxykinase from Mycobacterium smegmatis [PDF]

Journal of Biological Chemistry, 2006
The roles of Asp(75), Asp(78), and Glu(83) of the (75)DPSDVARVE(83) element of Mycobacterium smegmatis GTP-dependent phosphoenolpyruvate (PEP) carboxykinase (GTP-PEPCK) were investigated. Asp(78) and Glu(83) are fully conserved in GTP-PEP-CKs. The human PEPCK crystal structure suggests that Asp(78) influences Tyr(220); Tyr(220) helps to position bound ...
Christopher L, Case, Edward M, Concar, Kristin L, Boswell, Biswarup, Mukhopadhyay   +3 more
openaire   +4 more sources

Partial Purification and Characterization of Rat-Liver Messenger RNA Coding for Phosphoenolpyruvate Carboxykinase (GTP) [PDF]

European Journal of Biochemistry, 1978
The mRNA coding for the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) was partially purified from the liver of cyclic-AMP-treated rats by a procedure involving multiple oligo(dT)-cellulose chromatographies and sucrose gradient fractionations.
P B, Iynedjian, R W, Hanson
openaire   +3 more sources

Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.

Journal of Biological Chemistry, 1990
Vanadate, at concentrations between 0.5 and 2 mM, rapidly decreased the basal level of P-enolpyruvate carboxykinase (GTP) (EC 4.1.1.32) mRNA and blocked the dibutyryl cyclic AMP (Bt2cAMP)-induced increase in enzyme mRNA in both FTO-2B and H4IIE rat hepatoma cells.
Bosch i Tubert, Fàtima, Hatzoglou, Maria, Park, Edwards A., Hanson, Richard W.   +3 more
openaire   +4 more sources

Overcoming Diabetes-Induced Hyperglycemia through Inhibition of Hepatic Phosphoenolpyruvate Carboxykinase (GTP) with RNAi [PDF]

Molecular Therapy, 2006
Phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32) is the rate-controlling enzyme in gluconeogenesis. In diabetic individuals, altered rates of gluconeogenesis are responsible for increased hepatic glucose output and sustained hyperglycemia. Liver-specific inhibition of PEPCK has not been assessed to date as a treatment for diabetes.
Gómez-Valadés, Alicia G., Vidal-Alabró, Anna, Molas, Maria, Boada, Jordi, Bermúdez, Jordi, Bartrons, Ramon, Perales, José C.   +6 more
openaire   +3 more sources

Nuclear Factor I Regulates Expression of the Gene for Phosphoenolpyruvate Carboxykinase (GTP) [PDF]

Journal of Biological Chemistry, 1998
Nuclear factor-I (NFI) binds to the phosphoenolpyruvate carboxykinase (GTP) (PEPCK) gene promoter immediately 5' to the cAMP regulatory element (CRE). This suggests an interaction between NFI and factors that bind the CRE. Of the four NFI isoforms expressed in mammalian tissues, NFI-A and -B stimulate basal transcription from the PEPCK gene promoter in
D R, Crawford, P, Leahy, C Y, Hu, A, Chaudhry, R, Gronostajski, G, Grossman, J, Woods, P, Hakimi, W J, Roesler, R W, Hanson   +9 more
openaire   +4 more sources

Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation.

Journal of Biological Chemistry, 1988
It is now well established that cAMP induces the transcription rate of the gene for phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) and that this induction is dependent on a nucleotide domain located within the promoter-regulatory region of the gene (Short, J. M., Wynshaw-Boris, A., Short, H. P., and Hanson, R. W. (1986) J. Biol. Chem.
Y, Hod, R W, Hanson
openaire   +3 more sources