Results 21 to 30 of about 3,076 (182)

Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors. [PDF]

PLoS ONE, 2016
There exist two isoforms of cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in pig populations that differ in a single amino acid (Met139Leu). The isoenzymes have different kinetic properties, affecting more strongly the Km and Vmax of nucleotides.
Jorge Hidalgo, Pedro Latorre, José Alberto Carrodeguas, Adrián Velázquez-Campoy, Javier Sancho, Pascual López-Buesa   +5 more
doaj   +1 more source

Mixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic Cleft. [PDF]

PLoS ONE, 2015
Cytosolic phosphoenolpyruvate carboxykinase (cPEPCK) is a critical enzyme involved in gluconeogenesis, glyceroneogenesis and cataplerosis. cPEPCK converts oxaloacetic acid (OAA) into phosphoenol pyruvate (PEP) in the presence of GTP.
Shashank Prakash Katiyar, Arpit Jain, Jaspreet Kaur Dhanjal, Durai Sundar   +3 more
doaj   +1 more source

Processing of phosphoenolpyruvate carboxykinase (GTP) RNA in vivo. [PDF]

Proceedings of the National Academy of Sciences, 1985
Nuclear RNA precursors to the mRNA for rat cytosolic phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) and nuclear RNA species smaller in size than the mature enzyme mRNA have been identified by using hybridization probes specific for introns and exons from the gene.
Constantine E. Sekeris, Richard W. Hanson, Maria Hatzoglou   +2 more
openaire   +3 more sources

Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression

European Journal of Immunology, Volume 53, Issue 12, December 2023., 2023
The level of metabolite PEP in host cells is increased in response to viral infection. PEP promotes AATK expression to inhibit viral replication and results in restricted inflammatory responses, both in vitro and in vivo. These findings indicate a potential application of up‐regulation of PEP‐AATK axis in controlling viral infections.
Lu Zhao, Renjie Song, Yang Liu
wiley   +1 more source

Integrating multiple regulations on enzyme activity: the case of phospho enol pyruvate carboxykinases [PDF]

, 2023
Data on protein post-translational modifications (PTMs) increased exponentially in the last years due to the refinement of mass spectrometry techniques and the development of databases to store and share datasets.
Iglesias, Alberto Alvaro, Rojas, Bruno Ezequiel   +1 more
core   +1 more source

Biochemical, structural, and kinetic characterization of PPi‐dependent phosphoenolpyruvate carboxykinase from Propionibacterium freudenreichii

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 9, Page 1261-1275, September 2023., 2023
Abstract Phosphoenolpyruvate carboxykinases (PEPCK) are a well‐studied family of enzymes responsible for the regulation of TCA cycle flux, where they catalyze the interconversion of oxaloacetic acid (OAA) and phosphoenolpyruvate (PEP) using a phosphoryl donor/acceptor.
Matthew J. McLeod, Todd Holyoak
wiley   +1 more source

Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M [PDF]

, 2021
Background: Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. The mitochondrial isozyme, PEPCK-M is highly expressed in cancer cells, where it plays a role in nutrient stress response. To date,
Abás Prades, Sònia, Aragó, Marc, Brea, José, Carrodeguas, Jose A., Escolano Mirón, Carmen, Figueras, Agnes, Galdeano, Carlos, García-Roves, Pablo M. (Pablo Miguel), Ginex, Tiziana, Hyrossová, Petra, Latorre, Pedro, Loza, María Isabel, Luque Garriga, F. Xavier, Moreno Felici, Juan, Perales Losa, Carlos, Pérez, Belén, Rodríguez Arévalo, Sergio, Viñals Canals, Francesc   +17 more
core   +1 more source

mir‐98‐5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes

Journal of Cell Communication and Signaling, Volume 17, Issue 3, Page 881-895, September 2023., 2023
Graphical abstract Abstract Several reports suggest that circulatory miRNAs are deregulated in diverse diseases and used as markers for disease diagnosis and prognosis. Here we show that miR‐98‐5p, that is down‐regulated in the circulation during diabetes, regulates hepatic gluconeogenesis and lipogenesis by targeting PPP1R15B. miR‐98‐5p overexpression
Rukshar Khan, Amit Kumar Verma, Malabika Datta   +2 more
wiley   +1 more source

The Tricarboxylic Acid Cycle as a Central Regulator of the Rate of Aging: Implications for Metabolic Interventions

Advanced Biology, Volume 7, Issue 7, July 2023., 2023
Certain metabolic interventions such as fasting and physical exercise can extend life‐ and/or health‐span but their effects are limited and their connections to underlying mechanisms of aging are unclear. In this review, metabolic interventions are explored in terms of the biochemistry of the tricarboxylic acid cycle.
Jonathan M. Borkum
wiley   +1 more source

Genome‐wide exploration reveals distinctive northern and southern variants of Clonorchis sinensis in the Far East

Molecular Ecology Resources, Volume 23, Issue 4, Page 833-843, May 2023., 2023
Abstract Clonorchis sinensis is a carcinogenic liver fluke that causes clonorchiasis—a neglected tropical disease (NTD) affecting ~35 million people worldwide. No vaccine is available, and chemotherapy relies on one anthelmintic, praziquantel. This parasite has a complex life history and is known to infect a range of species of intermediate (freshwater
Liina Kinkar, Pasi K. Korhonen, Urmas Saarma, Tao Wang, Xing‐Quan Zhu, Ivon Harliwong, Bicheng Yang, J. Lynn Fink, Daxi Wang, Bill C. H. Chang, Galina N. Chelomina, Anson V. Koehler, Neil D. Young, Robin B. Gasser   +13 more
wiley   +1 more source