Results 41 to 50 of about 2,330 (168)

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, Volume 45, Issue 11, Page 1367-1406, November 2025.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Insulin decreases phosphoenolpyruvate carboxykinase (GTP) mRNA activity by a receptor-mediated process.

Journal of Biological Chemistry, 1982
The mRNA that codes for phosphoenolpyruvate carboxykinase accounts for approximately 0.2% of the protein synthesized in H4IIEC3 hepatoma cells maintained for 24 h in serum-free medium containing N6,O2'-dibutyryl cAMP and theophylline. This value decreases to 0.04% within 3 h after the addition of insulin.
T L, Andreone, E G, Beale, R S, Bar, D K, Granner   +3 more
openaire   +2 more sources

Brown adipose tissue activity impacts systemic lactate clearance in male mice

The Journal of Physiology, Volume 603, Issue 22, Page 6811-6832, November 15, 2025.
Abstract figure legend Using lactate tolerance tests and in vivo 13C isotopic tracing experiments performed in male mice housed at different temperatures, this study demonstrates that the state of activation of non‐shivering thermogenesis in brown adipose tissue (BAT) impacts systemic lactate metabolism.
Rémi Montané, Yannick Jeanson, Damien Lagarde, Spiro Khoury, Léana Porcher‐Bibes, Jean Nakhle, Marie Sallese, Mélissa Parny, Isabelle Raymond‐Letron, Emma Huard, Raphael Alves de Souza, Anne Galinier, Luc Pellerin, Anne‐Karine Bouzier Sore, Jean‐Philippe Pradère, Cédric Moro, Louis Casteilla, Armelle Yart, Cédric Dray, Jean‐Charles Portais, Isabelle Ader, Audrey Carriere   +21 more
wiley   +1 more source

Changes in hepatic messenger RNA for phospho enol pyruvate carboxykinase (GTP) during development [PDF]

Proceedings of the National Academy of Sciences, 1978
Phospho enol pyruvate carboxykinase (GTP) [GTP;oxaloacetate carboxy-lyase(transphosphorylating); EC 4.1.1.32] is absent in rat liver cytosol during fetal life and is synthesized initially at birth. De novo synthesis of the enzyme can be induced prematurely by injection of dibutyryl cyclic AMP
J P, Garcia Ruiz, R, Ingram, R W, Hanson
openaire   +2 more sources

Advances and Deep Insights Into Lactylation: Essential Roles in Cellular Regulation and Disease Association

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT Proteins exert biological functions not only depending on abundance but also on regulation. Lactylation is an important novel post‐translational modification (PTM) that can affect protein structure and function, playing a crucial role in signal transduction, gene expression and cellular metabolism.
Tong Pan, Can‐can Du, Ying‐jian Zhang, Zhen‐long Liu   +3 more
wiley   +1 more source

Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines. [PDF]

Proceedings of the National Academy of Sciences, 1989
The gene encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) [PEPCK; GTP:oxaloacetate carboxy-lyase (transphosphorylating), EC 4.1.1.32], a key enzyme in gluconeogenesis and glyceroneogenesis, is expressed in tissues that arise from different embryonal origins: the gluconeogenic liver arises from endoderm, whereas the gluconeogenic kidney cortex
N, Benvenisty, H, Nechushtan, H, Cohen, L, Reshef   +3 more
openaire   +2 more sources

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, Volume 292, Issue 12, Page 2973-2991, June 2025.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

Signatures of Selection for Resistance/Tolerance to Perkinsus olseni in Grooved Carpet Shell Clam (Ruditapes decussatus) Using a Population Genomics Approach

Evolutionary Applications, Volume 18, Issue 5, May 2025.
ABSTRACT The grooved carpet shell clam (Ruditapes decussatus) is a bivalve of high commercial value distributed throughout the European coast. Its production has suffered a decline caused by different factors, especially by the parasite Perkinsus olsenii. Improving production of R.
Inés M. Sambade, João Estêvão, Marina Pampín, Andreia Cruz, Eric Guévélou, Andrés Blanco, Francisco Câmara, Jessica Gómez‐Garrido, Fernando Cruz, Luca Bargelloni, Stefano Carboni, Tyler Alioto, Benjamin Costas, Sergio Fernández‐Boo, Paulino Martínez   +14 more
wiley   +1 more source

A cAMP-regulated RNA-binding protein that interacts with phosphoenolpyruvate carboxykinase (GTP) mRNA.

Journal of Biological Chemistry, 1993
Cyclic-AMP stabilizes phosphoenolpyruvate carboxykinase (GTP) (PEPCK) mRNA against degradation. To investigate the mechanism of this effect, RNA mobility shift assays were used to determine the interaction of cellular proteins with specific domains from the mRNA.
N, Nachaliel, D, Jain, Y, Hod
openaire   +2 more sources

HSP70 as a Mediator of Host–Pathogen Interaction in Arabidopsis thaliana During Plasmodiophora brassicae Infection

Physiologia Plantarum, Volume 177, Issue 3, May/June 2025.
ABSTRACT Plasmodiophora brassicae is one of the most devastating threats to Brassicaceae crops. However, the molecular mechanisms underlying clubroot disease remain unclear. Initial proteomics results led us to hypothesize that HSP70 proteins regulate host–P. brassicae interactions by modulating both plant defenses and pathogen activity.
Romana Kopecká, Miroslav Berka, Susann Auer, David Alabadí, Markéta Luklová, Sunita Jindal, Jutta Ludwig‐Müller, Martin Černý   +7 more
wiley   +1 more source