Results 41 to 50 of about 10,168 (226)

A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis

Cancer Communications, 2020
Highly active lipogenesis is essential for rapid tumor growth. Sterol regulatory element‐binding protein (SREBP) is a key transcriptional factor for lipogenesis and activated by reduced sterol and oxysterol levels.
Hongfei Jiang, Lei Zhu, Daqian Xu, Zhimin Lu   +3 more
doaj   +1 more source

Fasting‐Induced Hepatic Gluconeogenesis Is Compromised In Anxa6−/− Mice [PDF]

J Cell Physiol
ABSTRACT Maintaining constant blood glucose levels is essential for energizing glucose‐dependent tissues. During the fed state, insulin lowers elevated blood glucose, while in the fasted state, glucagon maintains blood glucose levels through hepatic stimulation of fatty acid oxidation, glycogenolysis, and gluconeogenesis (GNG).
Alvarez‐Guaita A, Bernaus‐Esqué M, Blanco‐Muñoz P, Liu Y, Sebastian D, Meneses‐Salas E, Nguyen M, Zorzano A, Tebar F, Enrich C, Grewal T, Rentero C.   +11 more
europepmc   +2 more sources

Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression

European Journal of Immunology, Volume 53, Issue 12, December 2023., 2023
The level of metabolite PEP in host cells is increased in response to viral infection. PEP promotes AATK expression to inhibit viral replication and results in restricted inflammatory responses, both in vitro and in vivo. These findings indicate a potential application of up‐regulation of PEP‐AATK axis in controlling viral infections.
Lu Zhao, Renjie Song, Yang Liu
wiley   +1 more source

Biochemical, structural, and kinetic characterization of PPi‐dependent phosphoenolpyruvate carboxykinase from Propionibacterium freudenreichii

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 9, Page 1261-1275, September 2023., 2023
Abstract Phosphoenolpyruvate carboxykinases (PEPCK) are a well‐studied family of enzymes responsible for the regulation of TCA cycle flux, where they catalyze the interconversion of oxaloacetic acid (OAA) and phosphoenolpyruvate (PEP) using a phosphoryl donor/acceptor.
Matthew J. McLeod, Todd Holyoak
wiley   +1 more source

mir‐98‐5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes

Journal of Cell Communication and Signaling, Volume 17, Issue 3, Page 881-895, September 2023., 2023
Graphical abstract Abstract Several reports suggest that circulatory miRNAs are deregulated in diverse diseases and used as markers for disease diagnosis and prognosis. Here we show that miR‐98‐5p, that is down‐regulated in the circulation during diabetes, regulates hepatic gluconeogenesis and lipogenesis by targeting PPP1R15B. miR‐98‐5p overexpression
Rukshar Khan, Amit Kumar Verma, Malabika Datta   +2 more
wiley   +1 more source

The Tricarboxylic Acid Cycle as a Central Regulator of the Rate of Aging: Implications for Metabolic Interventions

Advanced Biology, Volume 7, Issue 7, July 2023., 2023
Certain metabolic interventions such as fasting and physical exercise can extend life‐ and/or health‐span but their effects are limited and their connections to underlying mechanisms of aging are unclear. In this review, metabolic interventions are explored in terms of the biochemistry of the tricarboxylic acid cycle.
Jonathan M. Borkum
wiley   +1 more source

Phosphoenolpyruvate Carboxykinase Is Involved in the Decarboxylation of Aspartate in the Bundle Sheath of Maize [PDF]

, 1999
We recently showed that maize (Zea mays L.) leaves contain appreciable amounts of phosphoenolpyruvate carboxykinase (PEPCK; R.P. Walker, R.M. Acheson, L.I. Técsi, R.C. Leegood [1997] Aust J Plant Physiol 24: 459–468).
Chen, Z., Leegood, R.C., Walker, R.P., Wingler, A.   +3 more
core   +2 more sources

Genome‐wide exploration reveals distinctive northern and southern variants of Clonorchis sinensis in the Far East

Molecular Ecology Resources, Volume 23, Issue 4, Page 833-843, May 2023., 2023
Abstract Clonorchis sinensis is a carcinogenic liver fluke that causes clonorchiasis—a neglected tropical disease (NTD) affecting ~35 million people worldwide. No vaccine is available, and chemotherapy relies on one anthelmintic, praziquantel. This parasite has a complex life history and is known to infect a range of species of intermediate (freshwater
Liina Kinkar, Pasi K. Korhonen, Urmas Saarma, Tao Wang, Xing‐Quan Zhu, Ivon Harliwong, Bicheng Yang, J. Lynn Fink, Daxi Wang, Bill C. H. Chang, Galina N. Chelomina, Anson V. Koehler, Neil D. Young, Robin B. Gasser   +13 more
wiley   +1 more source

Signatures of Selection for Resistance/Tolerance to <i>Perkinsus olseni</i> in Grooved Carpet Shell Clam (<i>Ruditapes decussatus</i>) Using a Population Genomics Approach. [PDF]

Evol Appl
ABSTRACT The grooved carpet shell clam (Ruditapes decussatus) is a bivalve of high commercial value distributed throughout the European coast. Its production has suffered a decline caused by different factors, especially by the parasite Perkinsus olsenii. Improving production of R.
Sambade IM, Estêvão J, Pampín M, Cruz A, Guévélou E, Blanco A, Câmara F, Gómez-Garrido J, Cruz F, Bargelloni L, Carboni S, Alioto T, Costas B, Fernández-Boo S, Martínez P.   +14 more
europepmc   +2 more sources

Consequences of Postnatally Elevated Insulin-Like Growth Factor-II in Transgenic Mice: Endocrine Changes and Effects on Body and Organ Growth. [PDF]

, 1994
Insulin-like growth factor-II (IGF-II) is an important regulator of embryonic growth and differentiation, but its function in postnatal life is unclear. To address this point, we generated transgenic mice harboring fusion genes in which a human IGF-II
Blum, Werner F., Brem, Gottfried, Föll, Jürgen, Kramer, Rainer, Wolf, Eckhard   +4 more
core   +1 more source