Results 41 to 50 of about 3,076 (182)

A comparative study at bioprocess and metabolite levels of superhost strain Streptomyces coelicolor M1152 and its derivative M1581 heterologously expressing chloramphenicol biosynthetic gene cluster

open access: yesBiotechnology and Bioengineering, Volume 119, Issue 1, Page 145-161, January 2022., 2022
Development and application of powerful target metabolite profiling methodology to monitor how primary metabolism support precursors and energy for heterologous secondary metabolite production in Streptomyces superhost strains Abstract Microbial superhost strains should provide an ideal platform for the efficient homologous or heterologous phenotypic ...
Kanhaiya Kumar, Per Bruheim
wiley   +1 more source

Phosphoenolpyruvate Carboxykinase Is Involved in the Decarboxylation of Aspartate in the Bundle Sheath of Maize [PDF]

open access: yes, 1999
We recently showed that maize (Zea mays L.) leaves contain appreciable amounts of phosphoenolpyruvate carboxykinase (PEPCK; R.P. Walker, R.M. Acheson, L.I. Técsi, R.C. Leegood [1997] Aust J Plant Physiol 24: 459–468).
Chen, Z.   +3 more
core   +2 more sources

Drug Discovery of Plausible Lead Natural Compounds That Target the Insulin Signaling Pathway: Bioinformatics Approaches

open access: yesEvidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
The growing smooth talk in the field of natural compounds is due to the ancient and current interest in herbal medicine and their potentially positive effects on health. Dozens of antidiabetic natural compounds were reported and tested in vivo, in silico, and in vitro. The role of these natural compounds, their actions on the insulin signaling pathway,
Siba Shanak   +6 more
wiley   +1 more source

Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer

open access: yesBioMed Research International, Volume 2022, Issue 1, 2022., 2022
One of the globally common cancers is colorectal cancer (CRC). At present, a surgical approach remains a good option for CRC patients; however, 20% of surgically treated CRC patients experience metastasis. Currently, even the first‐line used drug, oxaliplatin, remains inadequate for treating metastatic CRC, and its side effect of neurotoxicity is a ...
Md Misbah   +4 more
wiley   +1 more source

Identification of vicinal thiols of phosphoenolpyruvate carboxykinase (GTP).

open access: yesJournal of Biological Chemistry, 1993
Phosphoenolpyruvate carboxykinase (PEPCK) from the cytosol of rat liver has 13 cysteines, at least one of which (Cys288) is known to be very reactive and critical for catalytic activity (Lewis, C. T., Seyer, J. M., and Carlson, G. M. (1989) J. Biol. Chem. 264, 27-33).
C T Lewis   +3 more
openaire   +3 more sources

Intestinal gluconeogenesis and glucose transport according to body fuel availability in rats [PDF]

open access: yesJ Physiol 566 (15/07/2005) 575-86, 2007
Intestinal hexose absorption and gluconeogenesis have been studied in relation to refeeding after two different fasting phases: a long period of protein sparing during which energy expenditure is derived from lipid oxidation (phase II), and a later phase characterized by a rise in plasma corticosterone triggering protein catabolism (phase III).
arxiv   +1 more source

Illegitimate recombination: An efficient method for random mutagenesis in Mycobacterium avium subsp. hominissuis

open access: yesBMC Microbiology, 2012
Background The genus Mycobacterium (M.) comprises highly pathogenic bacteria such as M. tuberculosis as well as environmental opportunistic bacteria called non-tuberculous mycobacteria (NTM).
Khattak Faisal   +4 more
doaj   +1 more source

Prolonging assembly through dissociation:A self assembly paradigm in microtubules [PDF]

open access: yesPhys. Rev. E 83, 051904 (2011), 2009
We study a one-dimensional model of microtubule assembly/disassembly in which GTP bound to tubulins within the microtubule undergoes stochastic hydrolysis. In contrast to models that only consider a cap of GTP-bound tubulin, stochastic hydrolysis allows GTP-bound tubulin remnants to exist within the microtubule.
arxiv   +1 more source

Consequences of Postnatally Elevated Insulin-Like Growth Factor-II in Transgenic Mice: Endocrine Changes and Effects on Body and Organ Growth. [PDF]

open access: yes, 1994
Insulin-like growth factor-II (IGF-II) is an important regulator of embryonic growth and differentiation, but its function in postnatal life is unclear. To address this point, we generated transgenic mice harboring fusion genes in which a human IGF-II
Blum, Werner F.   +4 more
core   +1 more source

Mn2+-sensitive and -insensitive forms of phosphoenolpyruvate carboxykinase (GTP).

open access: yesJournal of Biological Chemistry, 1981
Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) from rat liver cytosol is activated by micromolar concentrations of Mn2+ under conditions where GTP is present as the MgGTP complex and free Mg2+ is present in excess. The purified, homogeneous enzyme rapidly loses the ability to be activated by Mn2+ upon storage, incubation with oxidized ...
R I Brinkworth   +3 more
openaire   +3 more sources

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