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Prognostic significance of phosphoglycerate dehydrogenase in breast cancer
Breast Cancer Research and Treatment, 2021Breast cancer is the most common type of cancer affecting women worldwide. Phosphoglycerate dehydrogenase (PHGDH) is an oxidoreductase in the serine biosynthesis pathway. Although it has been reported to affect growth of various tumors, its role in breast cancer is largely unknown.
Muthukrishnan Chandrika +8 more
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[Phosphoglycerate dehydrogenase deficiency in a child].
Zhonghua er ke za zhi = Chinese journal of pediatrics, 2023X. Zhang, C. Ding, S. S. Ren
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Phosphoglycerate dehydrogenase (PHGDH) deficiency without epilepsy mimicking primary microcephaly
American Journal of Medical Genetics Part A, 2017Phosphoglycerate dehydrogenase (PHGDH) deficiency (OMIM 256520) is a rare autosomal recessive disorder of serine synthesis, with mostly severe congenital microcephaly, caused by mutations in the PHGDH gene. Fourteen patients reported to date show severe, early onset, drug resistant epilepsy.
A. Poli +12 more
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Journal of Agricultural and Food Chemistry, 2021
Two previously undescribed compounds, moranigrine A (1) and morusamine (2), along with 18 known compounds were isolated from the fruits of Morus nigra Linn.
Yali Wang +8 more
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Two previously undescribed compounds, moranigrine A (1) and morusamine (2), along with 18 known compounds were isolated from the fruits of Morus nigra Linn.
Yali Wang +8 more
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Multiconformational States in Phosphoglycerate Dehydrogenase,
Biochemistry, 2004Phosphoglycerate dehydrogenase (PGDH) catalyzes the first step in the serine biosynthetic pathway. In lower plants and bacteria, the PGDH reaction is regulated by the end-product of the pathway, serine. The regulation occurs through a V(max) mechanism with serine binding and inhibition occurring in a cooperative manner.
Jessica K, Bell +2 more
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Low Phosphoglycerate Dehydrogenase Levels Drive Metastatic Dissemination
Cancer Discovery, 2022Abstract Heterogeneous expression of phosphoglycerate dehydrogenase (PHGDH) promotes early metastasis.
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The gene encoding rat 3-phosphoglycerate dehydrogenase
Mammalian Genome, 2000Journal Article ; Research Support, Non-U.S.
Robbi, M. +3 more
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Phosphoglycerate‐kinase‐glyceraldehyde‐3‐phosphate‐dehydrogenase Interaction
European Journal of Biochemistry, 1995When rabbit muscle phosphoglycerate kinase (PGK; a 48‐kDa monomeric protein) and glyceraldehyde‐3‐phosphate dehydrogenase (GraPDH; a 145‐kDa homotetrameric protein) are present together in solution in the proportion of 1 mol PGK1 mol GraPDH monomer (total protein 0.2–1.0 mg/ml), an 80–82‐kDa protein species is observed by gel‐penetration (dilution ...
O P, Malhotra +3 more
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Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
Bioorganic chemistry (Print), 2019Serine plays critically important roles in tumorigenesis. Homo sapiens 3-phosphoglycerate dehydrogenase (PHGDH) catalyzes the first committed step for the synthesis of glucose-derived serine via the phosphoserine pathway and has been associated with a ...
Jing Guo +5 more
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Stereospecificity of hydrogen transfer by phosphoglycerate dehydrogenase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1975Phosphoglycerate dehydrogenase (EC 1.1.1.95) has been shown to be A site specific in its hydrogen transfer capacity unlike other dehydrogenases which use phosphorylated substrates. The experiments have been carried out using a coupled assay system with yeast alcohol dehydrogenase. The specific activity measurements of the reaction products indicate the
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