Results 181 to 190 of about 182,707 (224)
Stability & Flexibility of 3‐Phosphoglycerate Dehydrogenase
The FASEB Journal, 2006 Thai Vo +4 more
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Immunometabolism and rheumatic disease-advancing targeted therapies. [PDF]
EULAR Rheumatol OpenBoothby MR.
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The function of phosphoglycerate mutase 1 (PGAM1) and its role in diseases. [PDF]
Front Mol BiosciPeng A, Li J, Liang H, Yao Y, Zhang K.
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Amino acid activation of 3-phosphoglycerate dehydrogenase from peas
Phytochemistry, 1975 When l-methionine was added to an extract of etiolated pea epicotyls activation of 3-phosphoglycerate dehydrogenase occurred and was complete in 20-30 min.
J Colin Slaughter
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Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020
Expert Opinion on Therapeutic Patents, 2021 Introduction:The phosphoglycerate dehydrogenase (PHGDH), a metabolic enzyme involved in the serine synthetic pathway (SSP), appears to play a central role in supporting cancer growth and proliferation. PHGDH is a dehydrogenase whose expression in cancers
Raphaël Frédérick, Quentin Spillier
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Contrasting catalytic and allosteric mechanisms for phosphoglycerate dehydrogenases [PDF]
Archives of Biochemistry and Biophysics, 2012 D-3-Phosphoglycerate dehydrogenases (PGDH) exist with at least three different structural motifs and the enzymes from different species display distinctly different mechanisms. In many species, particularly bacteria, the catalytic activity is regulated allosterically through binding of l-serine to a distinct structural domain, termed the ACT domain ...
Gregory A Grant
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Autophagy, 2022 Macroautophagy/autophagy is a finely-regulated process in which cytoplasm encapsulated within transient organelles termed autophagosomes is delivered to lysosomes or vacuoles for degradation.
Yu-Tong Jiang, Bin Guan, Hong-Wei Xue
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Prognostic significance of phosphoglycerate dehydrogenase in breast cancer
Breast Cancer Research and Treatment, 2021Breast cancer is the most common type of cancer affecting women worldwide. Phosphoglycerate dehydrogenase (PHGDH) is an oxidoreductase in the serine biosynthesis pathway. Although it has been reported to affect growth of various tumors, its role in breast cancer is largely unknown.
Muthukrishnan Chandrika +8 more
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Multiconformational States in Phosphoglycerate Dehydrogenase,
Biochemistry, 2004Phosphoglycerate dehydrogenase (PGDH) catalyzes the first step in the serine biosynthetic pathway. In lower plants and bacteria, the PGDH reaction is regulated by the end-product of the pathway, serine. The regulation occurs through a V(max) mechanism with serine binding and inhibition occurring in a cooperative manner.
Jessica K, Bell +2 more
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