Association of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase and 3-phosphoglycerate kinase The biochemical and electron-microscopic evidence [PDF]
FEBS Letters, 1988 Rabbit muscle glyceraldehyde-3-phosphate dehydrogenase covalently bound to Sepharose was shown to form a complex with soluble 3-phosphoglycerate kinase. The strength of the association appeared to depend upon the functional state of both enzymes.
Vladimir Muronetz, N K Nagradova
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Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020
Expert Opinion on Therapeutic Patents, 2021 Introduction:The phosphoglycerate dehydrogenase (PHGDH), a metabolic enzyme involved in the serine synthetic pathway (SSP), appears to play a central role in supporting cancer growth and proliferation. PHGDH is a dehydrogenase whose expression in cancers
Raphaël Frederick
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Interaction betweend-glyceraldehyde-3-phosphate dehydrogenase and 3-phosphoglycerate kinase and its functional consequences [PDF]
FEBS Letters, 1992 E. Colid-glyceraldehyde-3-phosphate dehydrogenase covalently bound to Sepharose was shown to form a complex with soluble E. coli 3-phosphoglycerate kinase with a stoichiometry of 1.77±0.61 kinase molecules per tetramer of the dehydrogenase and an ...
Vladimir Muronetz, N K Nagradova
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Amino acid activation of 3-phosphoglycerate dehydrogenase from peas
Phytochemistry, 1975 When l-methionine was added to an extract of etiolated pea epicotyls activation of 3-phosphoglycerate dehydrogenase occurred and was complete in 20-30 min.
Slaughter, J. Colin, J.Colin Slaughter
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Prognostic significance of phosphoglycerate dehydrogenase in breast cancer
Breast Cancer Research and Treatment, 2021Breast cancer is the most common type of cancer affecting women worldwide. Phosphoglycerate dehydrogenase (PHGDH) is an oxidoreductase in the serine biosynthesis pathway. Although it has been reported to affect growth of various tumors, its role in breast cancer is largely unknown.
Muthukrishnan Chandrika +8 more
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Multiconformational States in Phosphoglycerate Dehydrogenase,
Biochemistry, 2004Phosphoglycerate dehydrogenase (PGDH) catalyzes the first step in the serine biosynthetic pathway. In lower plants and bacteria, the PGDH reaction is regulated by the end-product of the pathway, serine. The regulation occurs through a V(max) mechanism with serine binding and inhibition occurring in a cooperative manner.
Jessica K, Bell +2 more
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Inhibition of 3-phosphoglycerate dehydrogenase by compounds other than l-serine
Phytochemistry, 1973 3-Phosphoglycerate dehydrogenase from etiolated pea epicotyls was not affected during in vitro assay by a range of hexose phosphates, amino group precursors and nucleotides at 1 mM but was significantly inhibited by 1 mM ATP and GTP.
Slaughter, J. Colin, J.Colin Slaughter
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The gene encoding rat 3-phosphoglycerate dehydrogenase
Mammalian Genome, 2000info:eu-repo/semantics ...
Robbi, M. +3 more
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Stereospecificity of hydrogen transfer by phosphoglycerate dehydrogenase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1975Phosphoglycerate dehydrogenase (EC 1.1.1.95) has been shown to be A site specific in its hydrogen transfer capacity unlike other dehydrogenases which use phosphorylated substrates. The experiments have been carried out using a coupled assay system with yeast alcohol dehydrogenase. The specific activity measurements of the reaction products indicate the
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Low Phosphoglycerate Dehydrogenase Levels Drive Metastatic Dissemination
Cancer Discovery, 2022Abstract Heterogeneous expression of phosphoglycerate dehydrogenase (PHGDH) promotes early metastasis.
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