Results 111 to 120 of about 31,695 (232)

The synthesis and processing of pea legumin in saccharomyces cerevisiae [PDF]

, 1987
An expression vector utilising the promoter from the yeast phosphoglycerate kinase gene and a complete protein-encoding sequence, was used to direct the expression of the pea seed storage protein, legumin, in yeast (Sciccharomyces cerevisicie) .
Chieng, Hock Ming
core  

Bisphosphonate Inhibition of Phosphoglycerate Kinase:  Quantitative Structure−Activity Relationship and Pharmacophore Modeling Investigation

, 2016
We report the results of a three-dimensional quantitative structure−activity relationship (3D-QSAR) and pharmacophore modeling investigation of the interaction of the enzyme 3-phosphoglycerate kinase (PGK) with aryl and alkyl bisphosphonates.
Evangelia Kotsikorou (1864414), Gurmukh Sahota (262239), Eric Oldfield (558367)   +2 more
core   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Limited proteolysis of 3-phosphoglycerate kinase without loss of enzymic activity

, 1988
During tryptic digestion of pig muscle 3-phosphoglycerate kinase in the presence of 3-phosphoglycerate both the decrease of enzymic activity and the release of trichloroacetic acid-soluble peptides occur after a pronounced lag period.
Shu-Xian Jiang, Vas, Mária, Mária Vas, Jiang, Shu-Xian   +3 more
core   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

The effect of substrates on the inter-domain interactions of the hinge-bending enzyme 3-phosphoglycerate kinase

, 1986
A hinge-bending mechanism has been proposed for phosphoglycerate kinase, in which the two domains bend about the connecting “swaist& rsquo; region. In partially denaturing concentrations of guanidinium chloride the substrate 3-phosphoglycerate stabilises
Benjamin Adams, Roger H. Pain, Pain, Roger H., Adams, Benjamin   +3 more
core   +1 more source

The glycolytic enzyme PGK1 phosphorylates MORC2 to Confer radioresistance in pancreatic ductal adenocarcinoma

Cell Death and Disease
Most pancreatic cancer patients exhibit inherent resistance to radiation therapy, and the molecular mechanisms remain poorly understood. Here, we demonstrate that phosphoglycerate kinase 1 (PGK1), a key ATP-producing glycolytic enzyme, plays a critical ...
Yingying Tong, Xin Liu, Qian Liu, Jing Wang, Yaoxian Xiang, Kangjie Wang, Zezhou Zhao, Ke Zhu, Lijun Yang, Li Wang, Dong Guo, Zhimin Lu, Dong Yan   +12 more
doaj   +1 more source

A human induced pluripotent stem cell line, NIMHi016-A, established from fibroblasts of a neuromuscular disease patient carrying PGK1/p. Asn5Lys variant

Stem Cell Research
PGK1 (phosphoglycerate kinase-1) is required for ATP production in the body. Mutation in the PGK1 gene causes a rare, inherited metabolic disorder causing deficiency of enzyme PGK1, leading to hemolytic anemia, neurological symptoms, and muscle weakness.
Bevinahalli Nanjegowda Nandeesh, Baduvandra Chettiyappa Maheshwari, Madhura Milind Nimonkar, Sekar Deepha, Periyasamy Govindaraj, Bhupesh Mehta, Yogananda S. Markandeya   +6 more
doaj   +1 more source

Genome‐wide association studies of a pea germplasm reveal novel markers and candidate genes implicated in resistance to Fusarium oxysporum f. sp. pisi races 1 and 2

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Pea (Pisum sativum L.) is an essential legume crop cultivated globally as food and feed. However, its production is greatly constrained by Fusarium oxysporum f. sp. pisi (Fop). Breeding for resistance is the most efficient management strategy, but the genetic foundation of Fop resistance remains unclear.
Osman Zakaria Wohor, Diego Rubiales, Nicolas Rispail   +2 more
wiley   +1 more source

Guard cell photorespiration controls stomata behavior and development

New Phytologist, Volume 250, Issue 5, Page 3182-3196, June 2026.
Summary Photorespiration is traditionally viewed as a limitation to photosynthetic efficiency. However, it is mandatory for safeguarding the Calvin–Benson–Bassham cycle from inhibitory byproducts through Rubisco‐mediated oxidative misfire and is tightly integrated with primary metabolism.
Hu Sun, Inken Thiemann, Nils Schmidt, Johannes Kromdijk, Tracy Lawson, Martin Hagemann, Stefan Timm   +6 more
wiley   +1 more source