Results 101 to 110 of about 31,695 (232)

Signature of functional enzyme dynamics in quasielastic neutron scattering spectra: The case of phosphoglycerate kinase

, 2023
International audienceWe present an analysis of high-resolution quasi-elastic neutron scattering spectra of phosphoglycerate kinase which elucidates the influence of the enzymatic activity on the dynamics of the protein.
Hassani, Abir N., Haris, Luman, Kneller, Gerald R., Kneller, Gerald, Appel, Markus, Hassani, Abir, Stadler, Andreas, Seydel, Tilo   +7 more
core   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao, Yue Xiao, Yi Cheng, Weihai Xu, Jing Shu, Shishi Li   +5 more
wiley   +1 more source

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

eLife, 2017
The mitochondrial unfolded protein response (UPRmt) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental mitochondrial stress activates UPRmt reporters and extends lifespan.
Martin Borch Jensen, Yanyan Qi, Rebeccah Riley, Liya Rabkina, Heinrich Jasper   +4 more
doaj   +1 more source

Photorespiration as a Thermal Protection Mechanism in Trees: Measurements, Assumptions, and Persistent Gaps

Global Change Biology Communications, Volume 1, Issue 2, June 2026.
Conceptual framework linking leaf‐level photorespiratory biochemistry to global‐scale uncertainty in carbon cycle modelling. Rubisco acts as a temperature‐sensitive biochemical switch: At optimal temperatures (~25°C) carboxylation dominates and drives biomass accumulation, whereas heat stress (> 35°C) favours oxygenation and initiates photorespiration (
Rakesh Tiwari, Christine H. Foyer, Robert Muscarella   +2 more
wiley   +1 more source

The Calvin cycle enzyme phosphoglycerate kinase of Xanthobacter flavus required for autotrophic CO2 fixation is not encoded by the cbb operon

, 1994
During autotrophic growth of Xanthobacter flavus, energy derived from the oxidation of hydrogen methanol or formate is used to drive the assimilation of CO2 via the Calvin cycle. The genes encoding the Calvin cycle enzymes are organized in the cbb operon,
Meijer, W. G., MEIJER, WG
core   +1 more source

Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mutant leukemia

Acta Pharmaceutica Sinica B
Phosphoglycerate kinase 1 (PGK1) is traditionally recognized for its pivotal role in glycolysis. Our findings reveal that PGK1 also functions as a protein kinase phosphorylating valosin-containing protein (VCP) at S746, which subsequently reduces Beclin ...
Huijing Wang, Fengyu Jiang, An Pan, Chenlong Jin, Yangyang Xue, Wenjie Liu, Renjun Gu, Yanyu Zhou, Qiuhong Shen, Tonghui Ma, Xiaoxuan Yu   +10 more
doaj   +1 more source

Serological response and diagnostic value of recombinant candida cell wall protein enolase, phosphoglycerate kinase and β- glucosidase

Frontiers in Microbiology, 2015
There are no specific signs and symtoms for invasive candidiasis (IC), which makes its diagnosis a challenge. Efforts have been made for decades to establish serological assays for rapid diagnosis of invasive candidiasis, but none of them have found ...
Zhengxin eHe, Jing eChen, Wei eLi, Yan eCheng, Hai-pu eZhang, Li-na eZhang, Tian-wen eHou   +6 more
doaj   +1 more source

Beyond Glycolysis: Targeting Non‐Glycolytic Metabolic Pathways in Brain Tumors for Therapeutic Innovation: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Metabolic reprogramming is a hallmark of brain tumors, extending beyond the classical Warburg effect. While glycolysis has been extensively studied, gliomas and pediatric high‐grade brain cancers demonstrate remarkable metabolic plasticity.
Iffat Islam Mayesha, Zubaier Ahmed, Ammarah Laaika Mohiuddin, Faiza Fairuz Muskan, Saiful Islam, Sharmin Jahan Sumaya   +5 more
wiley   +1 more source

Synthesis and Binding of Stable Bisubstrate Ligands for Phosphoglycerate Kinase

, 1998
Stable bisubstrate ligands of phosphoglycerate kinase (PGK) have been synthesised with AMP or ADP conjugated to hydrolytically-stable, symmetrical analogues of 1,3-bisphosphoglycerate and their binding to yeast PGK evaluated.
Vyle, Joseph; id_orcid, Williams, D.M., Jakeman, D.L., Blackburn, G.M., Williamson, M.P.   +4 more
core  

Phosphoglycerate kinase deficiency: biochemical and molecular genetic studies in a new myopathic variant (PGK Alberta)

, 1993
Biochemical analysis of muscle in a 37-year-old man with exercise intolerance, myalgia, recurrent myoglobinuria, and retinitis pigmentosa showed phosphoglycerate kinase (PGK) deficiency.
Dimauro S., Tonin P., Wyse J. P., Miranda A. F., Tsujino S., Brownell A. K., Shanske S.   +6 more
core   +1 more source