Results 81 to 90 of about 31,695 (232)

Proteomics analysis of antimalarial targets of Garcinia mangostana Linn.

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To investigate possible protein targets for antimalarial activity of Garcinia mangostana Linn. (G. mangostana) (pericarp) in 3D7 Plasmodium falciparum clone using 2-dimensional electrophoresis and liquid chromatography mass-spectrometry (LC/MS/
Wanna Chaijaroenkul, Artitiya Thiengsusuk, Kanchana Rungsihirunrat, Stephen Andrew Ward, Kesara Na-Bangchang   +4 more
doaj   +1 more source

CRISPR‐Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

Molecular Carcinogenesis, Volume 65, Issue 7, Page 874-887, July 2026.
ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha, Yue Liu, Gaga Geneti, Haojian Li, Xiaolin Wu, David Sun, Vaibhavi Gujar, Takashi Furusawa, Alexei Lobanov, Maggie Cam, Lipika R. Pal, Nishanth U. Nair, Chi‐Ping Day, Eytan Ruppin, Chandrayee Ghosh, Jiangnan Hu, Bhavishya Ramamoorthy, Suresh Kumar, Thorkell Andresson, King Chan, Maura O'Neill, Raj Chari, Yves Pommier, Jaydira Del Rivero, Urbain Weyemi, Electron Kebebew, Myriem Boufraqech   +26 more
wiley   +1 more source

Phosphoglycerate kinase from the extreme thermophile Thermus thermophilus Crystallization and preliminary X-ray data

, 1987
The glycolytic enzyme phosphoglycerate kinase has been prepared from the extreme thermophile Thermus thermophilus. In contrast to its eukaryote equivalents (yeast and horse muscle) this prokaryotic enzyme crystallizes from ammonium sulphate in the ...
Littlechild, J.A., Davies, G.J., J.A. Littlechild, Watson, H.C., H.C. Watson, S.J. Gamblin, G.J. Davies, Gamblin, S.J.   +7 more
core   +1 more source

Stimulation of yeast 3-phosphoglycerate kinase gene promoter by paraquat [PDF]

, 2000
Yeast cells exposed to adverse conditions employ a number of defense mechanisms in order to respond effectively to the stress and sustain a high proliferation rate.
Agius, Dorita, Vassallo, Neville, Bannister, William H., Balzan, Rena   +3 more
core   +1 more source

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

British Journal of Pharmacology, Volume 183, Issue 13, Page 3723-3742, July 2026.
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome, Masaaki Ueki, Takujiro Homma, Shinji Matsunaga, Saki Shimizu, Yukihiro Ohno, Shuhei Tomita   +6 more
wiley   +1 more source

Haploid accumulation and translational control of phosphoglycerate kinase-2 messenger RNA during mouse spermatogenesis [PDF]

, 1983
The intracellular location of the mRNA for the testis-specific isozyme of phosphoglycerate kinase-2 (PGK-2) has been determined for two spermatogenic cell types.
Hecht, Norman B., Fujimoto, Hirokazu, Kramer, James M., Gold, Bert, Erickson, Robert P.   +4 more
core   +1 more source

A Comprehensive Screening of the Interactors of Areca Palm Necrotic Ringspot Virus (ANRSV) HCPro2 Highlights the Proviral Roles of eIF4A and PGK in Viral Infection

Plants
The areca palm (Areca catechu L.), a medicinal tropical crop, hosts three novel viruses, areca palm necrotic ringspot virus (ANRSV), areca palm necrotic spindle-spot virus (ANSSV), and ANRSV2, which form a new genus Arepavirus in the family Potyviridae ...
Li Qin, Peilan Liu, Wentao Shen, Zhaoji Dai, Hongguang Cui   +4 more
doaj   +1 more source

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, Volume 49, Issue 7, Page 3543-3559, July 2026.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation

, 1997
Phosphoglycerate kinase (PGK), a key enzyme in glycolysis, catalyses the transfer of a phosphoryl-group from 1,3-bis-phosphoglycerate to ADP to form 3-phosphoglycerate and ATP.
Hol, Wim G. J., Bernstein, Bradley E., Wim G. J. Hol, Bradley E. Bernstein, Michels, Paulus, Paul A. M. Michels   +5 more
core   +1 more source

A novel PGK1 activator improves Alzheimer’s disease by regulating glycolysis

Alzheimer’s Research & Therapy
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the pathological accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Decreased glucose metabolism and ATP levels are well-established early biomarkers of AD. Recent
Mei Li, Nianzhuang Qiu, Wenhui Niu, Chenliang Qian, Yuqiong Zhang, Wubin Yang, Fengyang Ding, Hao Wang, Xiaoyan Xu, Jie Xia, Xuehui Zhang   +10 more
doaj   +1 more source