Results 51 to 60 of about 31,695 (232)

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Communication between the nucleotide site and the main molecular hinge of 3-phosphoglycerate kinase

, 2008
3-Phosphoglycerate kinase is a hinge-bending enzyme with substrate-assisted domain closure. However, the closure mechanism has not been described in terms of structural details.
Konarev, P. V., Varga, A., Svergun, D. I., Szabo, J., Zavodszky, P., Vas, M., Flachner, B.   +6 more
core   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Biosynthesis of cyclic 2,3-diphosphoglycerate Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus

, 1990
Starting from 2-phosphoglycerate the biosynthesis of cDPG comprises two steps: (i) the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate and (ii) the intramolecular cyclization to cyclic 2,3-diphosphoglycerate.
Hensel, Reinhard, Lehmacher, Anselm, Reinhard Hensel, Anne-Barbara Vogt, Vogt, Anne-Barbara, Anselm Lehmacher   +5 more
core   +1 more source

Isolation of Chloroplastic Phosphoglycerate Kinase [PDF]

Plant Physiology, 1990
We report here a method for the isolation of high specific activity phosphoglycerate kinase (EC 2.7.2.3) from chloroplasts. The enzyme has been purified over 200-fold from pea (Pisum sativum L.) stromal extracts to apparent homogeneity with 23% recovery.
J, Macioszek, J B, Anderson, L E, Anderson   +2 more
openaire   +2 more sources

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang, Xin‐Yue Han, Li‐An Huang, Yu‐Sheng Zhang, Heng Meng, An‐Ding Xu   +5 more
wiley   +1 more source

The effect of phosphate on the unfolding-refolding of phosphoglycerate kinase induced by guanidine hydrochloride

, 1988
Phosphate ions were found to stabilize the native structure of phosphoglycerate kinase without modifying the folding pathway. The transition curves obtained from different signals: enzyme activity, ellipticity at 220 nm and fluorescence intensity at 336 ...
Betton, J.M., Chardot, T., Yon, J.M., M. Desmadril, Mitraki, A., A. Mitraki, Y. Amigues, J.M. Betton, T. Chardot, Amigues, Y., Desmadril, M., J.M. Yon   +11 more
core   +1 more source

Control and regulation of gene expression: quantitative analysis of the expression of phosphoglycerate kinase in bloodstream form Trypanosoma brucei. [PDF]

, 2008
Isoenzymes of phosphoglycerate kinase in Trypanosoma brucei are differentially expressed in its two main life stages. This study addresses how the organism manages to make sufficient amounts of the isoenzyme with the correct localization, which processes
Stewart, M., Luu, V.-D., Clayton, C., Haanstra, J.R.; id_orcid, Westerhoff, H.V., Bakker, B.M., van Tuijl, J.H., Westerhoff, H.V.; id_orcid, Haanstra, J.R.   +8 more
core   +1 more source

Phosphoglyceric Kinase in Human Vascular Tissue.

Experimental Biology and Medicine, 1966
SummaryDeterminations were made of the phosphoglyceric kinase activities exhibited by intima-media layers of various types of human blood vessels. A total of 445 vascular specimens was included in the study. The average activity of the thoracic descending aorta expressed in millimoles of 1,3-diphos-phoglycerate formed per gram fresh tissue per hour was
J E, Kirk, E, Ritz
openaire   +2 more sources

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source