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AEs of phosphoinositide 3 kinase Inhibitors in patients with lymphoma
Reactions Weekly, 2022semanticscholar +2 more sources
The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α.
Journal of Medicinal Chemistry, 2012Inhibition of phosphoinositide 3-kinase (PI3K) signaling through PI3Kα has received significant attention for its potential in cancer therapy. While the PI3K pathway is a well-established and widely pursued target for the treatment of many cancer types due to the high frequency of abnormal PI3K signaling, glioblastoma multiforme (GBM) is particularly ...
Timothy Heffron +20 more
semanticscholar +3 more sources
Journal of Medicinal Chemistry, 2011
Phosphatidylinositol 3-kinase α (PI3Kα) is an important regulator of intracellular signaling pathways, controlling remarkably diverse arrays of physiological processes. Because the PI3K pathway is frequently up-regulated in human cancers, the inhibition of PI3Kα can be a promising approach to cancer therapy.
Okseon Kim +4 more
semanticscholar +4 more sources
Phosphatidylinositol 3-kinase α (PI3Kα) is an important regulator of intracellular signaling pathways, controlling remarkably diverse arrays of physiological processes. Because the PI3K pathway is frequently up-regulated in human cancers, the inhibition of PI3Kα can be a promising approach to cancer therapy.
Okseon Kim +4 more
semanticscholar +4 more sources
Pharmacophore modeling and 3D-QSAR analysis of phosphoinositide 3-kinase p110α inhibitors
Journal of Molecular Modeling, 2010Pharmacophore modeling studies were undertaken for a series of compounds belonging several groups of phosphoinositide 3-kinase (PI3K) p110alpha inhibitors: 4-morpholino-2-phenylquinazolines derivatives, pyrido[3',2':4,5]furo-[3,2-d]pyrimidine derivatives, imidazo[1,2-a]pyridine derivatives, sulfonylhydrazone substituted imidazo[1,2-a]pyridines, and ...
Yiping Li, Ya-wen Wang, Fuqiang Zhang
semanticscholar +3 more sources
4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase
Bioorganic and Medicinal Chemistry Letters, 2008Prakash Mistry
exaly +2 more sources
Duvelisib: A New Phosphoinositide-3-Kinase Inhibitor in Chronic Lymphocytic Leukemia
Future Oncology, 2019P110-γ and -δ act in lymphocytes chemotaxis, presenting distinct, nonredundant roles in B- and T-cell migration and adhesion to stromal cells. Moreover, phosphoinositide-3-kinase-γ inhibition contributes to regulate macrophage polarization inhibiting cancer growth.
Anna M Frustaci +5 more
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Phosphoinositide 3-kinase α inhibitors: a patent review
Expert Opinion on Therapeutic Patents, 2013The alpha isoform of the class 1A family of phosphatidylinositol 3-kinases (PI3Kα) has been extensively studied and exploited as a target for cancer drugs. A large number of compounds, from a wide variety of structural scaffolds, are in development. There is an ongoing debate about the desirability for selectivity between PI3Kα and the other isoforms ...
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Advances in the Development of Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors
Current Topics in Medicinal Chemistry, 2016The PI3K signaling cascade is the key moderator of cell proliferation, survival, motility, and apoptosis. Class I PI3K proteins are well characterized and linked to thrombosis (PI3Kβ), rheumatoid arthritis (PI3Kδ), and cancer (PI3Kα). In this review, we explore the latest progress in the design and development of selective Class I PI3K inhibitors from ...
Dima A, Sabbah +2 more
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Phosphoinositide 3‐kinase δ inhibitor as a novel therapeutic agent in asthma
Respirology, 2008Abstract: Multiple signal transduction pathways are involved in airway inflammation with one of the key signalling pathways being phosphoinositide 3‐kinase (PI3K). Numerous components of the PI3K pathway play an important role in the expression and activation of inflammatory mediators, inflammatory cell recruitment, immune cell function, airway ...
Seoung J, Park +2 more
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Bioorganic & Medicinal Chemistry, 2011
The monitoring of the drug behavior and distribution in biological system can provide information whether drug reaches its desired target, and a biological rationale for the design of new therapeutics. We have developed a family of potent fluorescent PI3Kα inhibitors in which part of the fluorophore was engineered to be a pharmacophore capable of ...
Donghee, Kim +4 more
openaire +2 more sources
The monitoring of the drug behavior and distribution in biological system can provide information whether drug reaches its desired target, and a biological rationale for the design of new therapeutics. We have developed a family of potent fluorescent PI3Kα inhibitors in which part of the fluorophore was engineered to be a pharmacophore capable of ...
Donghee, Kim +4 more
openaire +2 more sources