Results 261 to 270 of about 219,778 (281)

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

Journal of Medicinal Chemistry, 2016
Timothy Heffron, R. Heald, Chudi O. Ndubaku, Binqing Wei, Martin Augistin, Steven Do, K. Edgar, C. Eigenbrot, L. Friedman, E. Gancia, P. Jackson, G. Jones, A. Kolesnikov, Leslie B. Lee, J. Lesnick, C. Lewis, N. Mclean, Mario Mörtl, J. Nonomiya, Jodie Pang, Steve Price, W. Prior, L. Salphati, S. Sideris, S. Staben, S. Steinbacher, V. Tsui, J. Wallin, D. Sampath, A. Olivero   +29 more
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Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.

Journal of Medicinal Chemistry, 2016
L. Patel, J. Chandrasekhar, Jerry B. Evarts, Kristen T. Forseth, Aaron C. Haran, Carmen Ip, A. Kashishian, Musong Kim, David Koditek, S. Koppenol, L. Lad, E. Lepist, M. Mcgrath, Stephane Perreault, K. Puri, A. Villaseñor, J. Somoza, B. Steiner, J. Therrien, J. Treiberg, G. Phillips   +20 more
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Structural basis for isoform selectivity in a class of benzothiazole inhibitors of phosphoinositide 3-kinase γ.

Journal of Medicinal Chemistry, 2015
Philip N. Collier, G. Martínez-Botella, M. Cornebise, K. Cottrell, J. Doran, J. Griffith, S. Mahajan, F. Maltais, C. Moody, Emilie Porter Huck, Tiansheng Wang, A. Aronov   +11 more
semanticscholar   +1 more source

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.

Journal of Medicinal Chemistry, 2015
Kenneth Down, A. Amour, I. Baldwin, A. Cooper, A. Deakin, L. Felton, S. Guntrip, C. Hardy, Zoë A. Harrison, Kate L. Jones, P. Jones, S. Keeling, Joelle Le, S. Livia, F. Lucas, C. Lunniss, N. Parr, E. Robinson, P. Rowland, Sarah E. Smith, Daniel A. Thomas, G. Vitulli, Yoshiaki Washio, J. N. Hamblin   +23 more
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Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors

Bioorganic and Medicinal Chemistry, 2021
Yan Sun, Songwen Lin, Ming Ji
exaly  

Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors

Bioorganic and Medicinal Chemistry Letters, 2012
Yusuke Oka, Yasuyuki Fujii, Mayumi Endo   +2 more
exaly  

The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)

European Journal of Medicinal Chemistry, 2010
M Brawner Floyd, Andrea Olland, Yongbo Hu   +2 more
exaly  

Regioselective synthesis of 5- and 6-methoxybenzimidazole-1,3,5-triazines as inhibitors of phosphoinositide 3-kinase

Bioorganic and Medicinal Chemistry Letters, 2013
Michelle S Miller, Jo-Anne Pinson, Zhaohua Zheng   +2 more
exaly  

Discovery of new thienopyrimidine derivatives as potent and orally efficacious phosphoinositide 3-kinase inhibitors

Bioorganic and Medicinal Chemistry, 2018
Songwen Lin, Chunyang Wang, Ming Ji
exaly  

Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.

Journal of Medicinal Chemistry, 2011
Noel D'angelo, Tae-Seong Kim, K. Andrews, S. Booker, S. Caenepeel, Kui Chen, D. D'amico, Daniel J. Freeman, Jian Jiang, Longbin Liu, J. McCarter, Tisha San Miguel, E. Mullady, M. Schrag, R. Subramanian, Jin Tang, R. Wahl, Ling Wang, D. Whittington, Tian Wu, N. Xi, Yang Xu, P. Yakowec, Kevin C Yang, Leeanne P Zalameda, Nancy Zhang, P. Hughes, M. H. Norman   +27 more
semanticscholar   +1 more source